US5355898A
Expired / Lapsed
US
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Method for inducing extraskeletal bone growth in primates and for screening implants therefor
Assignee: South African Medical Research Council
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Filing: 1992-06-02
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Granted: 1994-10-18
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Expires: 2012-06-02
Abstract
Abstract A method for screening a selected material for its osteoconductive or osteoinductive potential, which includes implanting a structure comprising the material, extraskeletally into a baboon, and examining the structure a predetermined period of time after implantation to determine what amount of bone, if any, has formed on or within the structure.
Inventors
- 👤 Ugo Ripamonti
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:24
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/02; A61L27/12; A61B; A61B17/00; A61B17/56; A61B17/58; A61F; A61F2/00; A61F2/02; A61F2/28; A61F2310/00; A61F2310/00005; A61F2310/00179; A61F2310/00293
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
63 words
A method for evaluating the shape and configuration of a porous hydroxyapatite structure for its osteoconductive or osteoinductive potential, which method comprises: implanting the structure extraskeletally into a non-human primate; removing the structure from the primate after a predetermined period of time; and examining the structure after removal to determine approximately the amount of bone which has formed on or within the structure.
Claim 2
Independent Claim
63 words
A method for evaluating the shape and configuration of a porous hydroxyapatite structure for its osteoconductive or osteoinductive potential, which method comprises: implanting the structure extraskeletally into a non-human primate; removing the structure from the primate after a predetermined period of time; and examining the structure after removal to determine approximately the amount of bone which has formed on or within the structure.
Claim 3
Dependent Claim
16 words
A method as claimed in claim 1, wherein the structure is implanted intramuscularly in adult baboons.
Claim 4
Dependent Claim
29 words
The method as claimed in claim 2, wherein the primate is a baboon and the step of examining the structure comprises subjecting the structure to histological or histomorphometric analysis.
Claim 5
Dependent Claim
25 words
The method of claim 1, further comprising the step of, before the implanting step, selecting a structure having a porosity of between about 200-500 μm.
Claim 6
Dependent Claim
16 words
The method of claim 1, wherein the structure is examined after at least approximately 90 days.
Claim 7
Dependent Claim
15 words
The method of claim 1, wherein the structure is examined at a central core thereof.
Claim 8
Independent Claim
37 words
A method of inducing bone growth in a site in a primate where bone growth is required, which method comprises the steps of selecting a suitable porous hydroxyapatite structure, and implanting the structure at the site extraskeletally.
Claim 9
Independent Claim
37 words
A method of inducing bone growth in a site in a primate where bone growth is required, which method comprises the steps of selecting a suitable porous hydroxyapatite structure, and implanting the structure at the site extraskeletally.
Claim 10
Dependent Claim
12 words
The method of claim 7, wherein the primate is an adult baboon.
Claim 11
Dependent Claim
11 words
The method of claim 7, wherein the structure is implanted intramuscularly.
Claim 12
Dependent Claim
26 words
The method of claim 5, further comprising the step of, after implanting the structure, waiting at least approximately 90 days for sufficient bone growth to occur.
Claim 13
Independent Claim
48 words
A method of inducing bone growth in a site in a primate where bone growth is required, which method comprises the steps of preparing a hydroxyapatite structure to have a suitable shape and a porosity of between about 200-500 μm, and implanting the structure at the site extraskeletally.
Claim 14
Independent Claim
48 words
A method of inducing bone growth in a site in a primate where bone growth is required, which method comprises the steps of preparing a hydroxyapatite structure to have a suitable shape and a porosity of between about 200-500 μm, and implanting the structure at the site extraskeletally.
Claim 15
Dependent Claim
25 words
The method of claim 11, further comprising preparing the structure to be in the shape of a rod having a diameter of between 5-7 mm.
References Cited (Backward Citations)
No citation records indexed.
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| 3.5 Years (Year 4) | 1997-10-17 | 1998-04-18 | 1998-10-18 | $2000.00 | Window Closed / Lapsed |
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