US5354295A
Expired / Lapsed
US
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In an endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
Assignee: University of California
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Filing: 1992-02-24
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Granted: 1994-10-11
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Expires: 2012-02-24
Abstract
Abstract An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity. The vascular cavity is packed with the tip to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion if formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip. The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter is more easily tracked by providing a radioopaque proximal marker on the microcatheter and a corresponding indicator marker on the wire. Electrothrombosis is facilitate by placing the ground electrode on the distal end of the microcatheter and flowing current between the microcatheter electrode and the tip.
Inventors
- 👤 Guido Guglielmi
- 👤 Ivan Sepetka
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:52
CPC Classifications
A; A61; A61M; A61M25/00; A61M25/01; A61M25/09; A61B; A61B17/00; A61B17/12; A61B17/12022; A61B17/12099; A61B17/12109; A61B17/12113; A61B17/12131; A61B17/1214; A61B17/12145; A61B17/1215; A61B18/00; A61B18/04; A61B18/12; A61B18/14; A61B18/1492; A61B17/00234; A61B2017/00292; A61B2017/1205; A61B2017/12054; A61B2017/12063; A61B2017/12095; A61B17/22; A61B2017/22038; A61B2018/00636; A61B2018/00666; A61B2018/00678; A61B2018/00696; A61B2018/00761; A61B2018/00773; A61B2018/00875; A61B2018/00886; A61B18/1206; A61B2018/1226; A61B2018/1246; A61B2018/1253; A61B2018/126; A61B2018/1266; A61B2018/1405; A61B2018/1435; A61B2018/1495; A61B90/00; A61B90/39; A61B2090/3966; A61M2025/09175
Claims Analysis
Total Claims: 32
Claim 1
Independent Claim
139 words
A method for forming an occlusion within a vascular cavity having blood disposed therein comprising the steps of: endovascularly disposing a relaxed coil wire near an endovascular opening into said vascular cavity, said relaxed coil wire having no substantial memory of its predisposed shape other than at most a relaxed, simple helical shape; disposing a distal tip of said wire into said vascular cavity to substantially space fill said cavity to mechanically form said occlusion within said vascular cavity about said distal tip; and nonthermally detaching said distal tip from said wire to leave said distal tip within said vascular cavity, wherein nonthermal detachment is defined as a detachment without substantially increasing the temperature of said distal tip and wire, whereby said vascular cavity is occluded by said distal tip, and any thrombus formed by use of said tip.
Claim 2
Independent Claim
139 words
A method for forming an occlusion within a vascular cavity having blood disposed therein comprising the steps of: endovascularly disposing a relaxed coil wire near an endovascular opening into said vascular cavity, said relaxed coil wire having no substantial memory of its predisposed shape other than at most a relaxed, simple helical shape; disposing a distal tip of said wire into said vascular cavity to substantially space fill said cavity to mechanically form said occlusion within said vascular cavity about said distal tip; and nonthermally detaching said distal tip from said wire to leave said distal tip within said vascular cavity, wherein nonthermal detachment is defined as a detachment without substantially increasing the temperature of said distal tip and wire, whereby said vascular cavity is occluded by said distal tip, and any thrombus formed by use of said tip.
Claim 3
Dependent Claim
39 words
The method of claim 1 wherein said step of detaching said digital tip from said wire without substantially increasing the temperature of said distal tip and wire comprises the step of mechanically detaching said distal tip from said wire.
Claim 4
Dependent Claim
84 words
The method of claim 1 where said wire and tip are used within a microcatheter and where in said step of nonthermally detaching said distal tip from said wire said wire and tip are longitudinally displaced within said microcatheter, said microcatheter having a radio-opaque proximal marker, said wire and tip having collectively a single radio-opaque marker, said displacement of said wire and tip moving said single radio-opaque marker to the proximity of said proximal marker on said microcatheter when said tip is fully deployed.
Claim 5
Dependent Claim
40 words
The method of claim 1 wherein said step of disposing said tip into said vascular cavity to substantially space fill said cavity comprises the step of disposing a tip having a plurality of filaments extending therefrom to pack said cavity.
Claim 6
Dependent Claim
45 words
The method of claim 1 wherein said step of disposing said tip into said vascular cavity to substantially space fill said cavity comprises the step of disposing a long flexible tip folded upon itself a multiple number of times to substantially space fill said cavity.
Claim 7
Independent Claim
151 words
A method for forming an occlusion within a vascular cavity having blood disposed therein comprising the steps of: endovascularly disposing a wire within a microcatheter near an endovascular opening into said vascular cavity, said microcatheter having a distal tip electrode; disposing a distal tip of said wire into said vascular cavity to substantially space fill said cavity to form said occlusion within said vascular cavity about said distal tip by applying a current between an electrode on said distal end of said wire disposed into said cavity and said distal tip electrode on said microcatheter; and nonthermally detaching said distal tip from said wire to leave said distal tip within said vascular cavity, wherein nonthermal detachment is defined as a detachment without substantially increasing the temperature of said distal tip and wire, whereby said vascular cavity is occluded by said distal tip, and any thrombus formed by use of said tip.
Claim 8
Independent Claim
151 words
A method for forming an occlusion within a vascular cavity having blood disposed therein comprising the steps of: endovascularly disposing a wire within a microcatheter near an endovascular opening into said vascular cavity, said microcatheter having a distal tip electrode; disposing a distal tip of said wire into said vascular cavity to substantially space fill said cavity to form said occlusion within said vascular cavity about said distal tip by applying a current between an electrode on said distal end of said wire disposed into said cavity and said distal tip electrode on said microcatheter; and nonthermally detaching said distal tip from said wire to leave said distal tip within said vascular cavity, wherein nonthermal detachment is defined as a detachment without substantially increasing the temperature of said distal tip and wire, whereby said vascular cavity is occluded by said distal tip, and any thrombus formed by use of said tip.
Claim 9
Dependent Claim
104 words
A wire for use in formation of an occlusion within a vascular cavity used in combination with a microcatheter comprising: a core wire having a distal portion; and a detachable elongate tip portion extending said core wire for a predetermined lineal extent and adapted to being packed into said vascular cavity to form said occlusion in said vascular cavity and coupled to said distal portion of said core wire, said elongate tip portion being a relaxed coil having no substantial memory of its predisposed shape other than at most a relaxed, simple helical shape, whereby endovascular occlusion of said vascular cavity can be performed.
Claim 10
Dependent Claim
104 words
A wire for use in formation of an occlusion within a vascular cavity used in combination with a microcatheter comprising: a core wire having a distal portion; and a detachable elongate tip portion extending said core wire for a predetermined lineal extent and adapted to being packed into said vascular cavity to form said occlusion in said vascular cavity and coupled to said distal portion of said core wire, said elongate tip portion being a relaxed coil having no substantial memory of its predisposed shape other than at most a relaxed, simple helical shape, whereby endovascular occlusion of said vascular cavity can be performed.
Claim 11
Dependent Claim
31 words
The wire of claim 7 wherein said elongate tip portion is a long and substantially pliable segment adapted to be multiply folded upon itself to substantially space fill said vascular cavity.
Claim 12
Dependent Claim
39 words
The wire of claim 7 wherein said elongate tip portion is a segment adapted to be disposed in said vascular cavity and having a plurality of filaments extending therefrom to substantially space fill said vascular cavity when disposed therein.
Claim 13
Dependent Claim
71 words
The wire of claim 7 wherein said microcatheter has a pair of radioopaque markers disposed thereon and a distal end, and wherein said core wire has a radioopaque marker disposed thereon, said marker on said core wire being positioned in the proximity of one of said pair of markers on said microcatheter when said core wire is deployed, said other marker on said microcatheter indicating the distal end of said microcatheter.
Claim 14
Dependent Claim
15 words
The wire of claim 7 where said core wire and tip are coupled by polyester.
Claim 15
Dependent Claim
166 words
A microcatheter system for use in formation of an occlusion within a vascular cavity comprising: a microcatheter having a distal end adapted for disposition in the proximity of said vascular cavity, said distal end having an electrode disposed thereon; a conductive wire disposed in said microcatheter and longitudinally displaceable therein, said wire comprising: a core wire having a distal portion; and an elongate tip portion extending said core wire for a predetermined lineal extent and adapted to being packed into said vascular cavity to form said occlusion in said vascular cavity and coupled to said distal portion of said core wire, said occlusion being formed by means of applying a current between said tip portion and said electrode on said microcatheter when said tip portion is disposed into said vascular cavity, said elongate tip portion being a relaxed coil having no substantial memory of its predisposed shape other than at most a relaxed, simple helical shape, whereby endovascular occlusion of said vascular cavity can be performed.
Claim 16
Dependent Claim
166 words
A microcatheter system for use in formation of an occlusion within a vascular cavity comprising: a microcatheter having a distal end adapted for disposition in the proximity of said vascular cavity, said distal end having an electrode disposed thereon; a conductive wire disposed in said microcatheter and longitudinally displaceable therein, said wire comprising: a core wire having a distal portion; and an elongate tip portion extending said core wire for a predetermined lineal extent and adapted to being packed into said vascular cavity to form said occlusion in said vascular cavity and coupled to said distal portion of said core wire, said occlusion being formed by means of applying a current between said tip portion and said electrode on said microcatheter when said tip portion is disposed into said vascular cavity, said elongate tip portion being a relaxed coil having no substantial memory of its predisposed shape other than at most a relaxed, simple helical shape, whereby endovascular occlusion of said vascular cavity can be performed.
Claim 17
Dependent Claim
104 words
An improvement in a method for forming an occlusion within a vascular cavity having blood disposed therein comprising the step of: disposing a body into said vascular cavity without tending to induce any preferred geometric form for said vascular cavity by such disposition, said body being flexible, and shapeless, and having substantially no memory of its predisposed shape other than at most a relaxed, simple helical shape, said body being disposed into said vascular cavity to substantially impede movement of blood in said vascular cavity and to thereby form said occlusion within said vascular cavity, whereby said vascular cavity is occluded by said body.
Claim 18
Dependent Claim
104 words
An improvement in a method for forming an occlusion within a vascular cavity having blood disposed therein comprising the step of: disposing a body into said vascular cavity without tending to induce any preferred geometric form for said vascular cavity by such disposition, said body being flexible, and shapeless, and having substantially no memory of its predisposed shape other than at most a relaxed, simple helical shape, said body being disposed into said vascular cavity to substantially impede movement of blood in said vascular cavity and to thereby form said occlusion within said vascular cavity, whereby said vascular cavity is occluded by said body.
Claim 19
Dependent Claim
28 words
The method of claim 13 wherein said step of disposing said body in said vascular cavity comprises the step of packing said body to substantially obstruct said cavity.
Claim 20
Dependent Claim
35 words
The method of claim 14 where said step of packing said cavity with said body comprises the step of obstructing said cavity with a detachable elongate wire tip multiply folded upon itself in said cavity.
Claim 21
Dependent Claim
32 words
The method of claim 14 where said step of packing said cavity with said body comprises the step of obstructing said cavity with a body having a multiplicity of flexible filamentary shapes.
Claim 22
Dependent Claim
39 words
The method of claim 13 wherein said step of disposing said body into said vascular cavity comprises disposing in said vascular cavity means for slowing blood movement in said cavity to initiate formation of said occlusion in said cavity.
Claim 23
Dependent Claim
22 words
The method of claim 13 wherein the forming of said occlusion comprises the step of applying an electrical current to said body.
Claim 24
Dependent Claim
43 words
The method of claim 18 where said step of applying an electrical current to said body comprises the step of applying an electrical current between said body and a proximate electrode carried on a microcatheter used for disposing said body into said cavity.
Claim 25
Dependent Claim
22 words
The method of claim 13 wherein the forming of said occlusion comprises the step of mechanically forming said occlusion in said body.
Claim 26
Dependent Claim
31 words
The method of claim 13 wherein the forming of said occlusion comprises the step of applying an electrical current to said body and simultaneously mechanically forming said occlusion in said body.
Claim 27
Dependent Claim
153 words
A wire for use in formation of an occlusion within a vascular cavity used in combination with a microcatheter comprising: a core wire having a distal portion; a detachable elongate tip portion extending said core wire for a predetermined lineal extent adapted to being packed into said vascular cavity to form said occlusion in said vascular cavity and coupled to said distal portion of said core wire, said tip portion including a first flexible, shapeless segment having substantially no memory of its predisposition shape other than at most a relaxed, simple helical shape for disposition into said cavity and a second segment for coupling said first portion to said core wire, said second segment being adapted to be electrolysized upon application of current; and an insulating coating disposed on said first segment, said second segment being left exposed to permit selective electrolysis thereof, whereby endovascular occlusion of said vascular cavity can be performed.
Claim 28
Dependent Claim
153 words
A wire for use in formation of an occlusion within a vascular cavity used in combination with a microcatheter comprising: a core wire having a distal portion; a detachable elongate tip portion extending said core wire for a predetermined lineal extent adapted to being packed into said vascular cavity to form said occlusion in said vascular cavity and coupled to said distal portion of said core wire, said tip portion including a first flexible, shapeless segment having substantially no memory of its predisposition shape other than at most a relaxed, simple helical shape for disposition into said cavity and a second segment for coupling said first portion to said core wire, said second segment being adapted to be electrolysized upon application of current; and an insulating coating disposed on said first segment, said second segment being left exposed to permit selective electrolysis thereof, whereby endovascular occlusion of said vascular cavity can be performed.
Claim 29
Independent Claim
110 words
A method for forming an occlusion within a vascular cavity having blood disposed therein comprising the steps of: endovascularly disposing a wire near an endovascular opening into said vascular cavity; disposing a distal tip of said wire into said vascular cavity to substantially space fill said cavity to form said occlusion within said vascular cavity about said distal tip; forming an electrothrombosis in said vascular cavity by applying current through said distal tip; and mechanically detaching said distal tip from said wire to leave said distal tip within said vascular cavity, whereby said vascular cavity is occluded by said distal tip, and any thrombus formed by use of said tip.
Claim 30
Independent Claim
110 words
A method for forming an occlusion within a vascular cavity having blood disposed therein comprising the steps of: endovascularly disposing a wire near an endovascular opening into said vascular cavity; disposing a distal tip of said wire into said vascular cavity to substantially space fill said cavity to form said occlusion within said vascular cavity about said distal tip; forming an electrothrombosis in said vascular cavity by applying current through said distal tip; and mechanically detaching said distal tip from said wire to leave said distal tip within said vascular cavity, whereby said vascular cavity is occluded by said distal tip, and any thrombus formed by use of said tip.
Claim 31
Independent Claim
111 words
A method for forming an occlusion within a vascular cavity having blood disposed therein comprising the steps of: endovascularly disposing a wire within a microcatheter near an endovascular opening into said vascular cavity; disposing a distal tip of said wire into said vascular cavity to substantially space fill said cavity to form said occlusion within said vascular cavity about said distal tip by applying a current to said distal tip packed into said cavity; and mechanically detaching said distal tip from said wire to leave said distal tip within said vascular cavity, whereby said vascular cavity is occluded by said distal tip, and any thrombus formed by use of said tip.
Claim 32
Independent Claim
111 words
A method for forming an occlusion within a vascular cavity having blood disposed therein comprising the steps of: endovascularly disposing a wire within a microcatheter near an endovascular opening into said vascular cavity; disposing a distal tip of said wire into said vascular cavity to substantially space fill said cavity to form said occlusion within said vascular cavity about said distal tip by applying a current to said distal tip packed into said cavity; and mechanically detaching said distal tip from said wire to leave said distal tip within said vascular cavity, whereby said vascular cavity is occluded by said distal tip, and any thrombus formed by use of said tip.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-10-10 | 1998-04-11 | 1998-10-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-10-10 | 2002-04-11 | 2002-10-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-10-10 | 2006-04-11 | 2006-10-11 | $7700.00 | Window Closed / Lapsed |