US5354258A
Expired / Lapsed
US
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Ultra-high-speed extracorporeal ultrasound hyperthermia treatment method
Assignee: Technomed Medical Systems SA
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Filing: 1993-01-07
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Granted: 1994-10-11
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Expires: 2013-01-07
Abstract
Abstract An extracorporeal ultra-high-speed ultrasound hyperthermia treatment method consisting in transmitting and focussing on the tumor ultrasound wave trains at frequencies between 0.5 and 10 MHz with peak electric powers which may reach 20 Kw or more, the parameters which define the concentration of the treatment beam in the focal spot and the power being determined so that, irrespective of the depth and the nature of the tissue, the treatment time is in the order of that enabling significant destruction, preferably total destruction, of the target during the linear part of a curve showing the temperature increase as a function of time.
Inventors
- 👤 Jacques Dory
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 06:10
CPC Classifications
A; A61; A61N; A61N7/00; A61N7/02; A61B; A61B17/00; A61B2017/00017; A61B2017/00137; A61B2017/00154
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
211 words
A method of effecting an ultra-high-speed hyperthermia treatment of a region of a subject located at a known depth within the body, with compressional wave energy derived from ultrasonic transducer means for applying to said region a focussed beam transmitted in the form of periodic bursts of oscillations having a predetermined frequency and a predetermined peak power, each burst having a predetermined duration and the successive bursts being separated by time intervals, said method comprising the steps of: a) effecting tests with said ultrasonic transducer means on a target located at said depth within the body for determining the curve of temperature increase of said target as a function of the time of application of said compressional wave energy, said curve having a quasi-linear portion which starts at time zero and ends at a time t o ; b) determining the particular peak power of said burst of oscillations which will provide at least a substantial destruction of said region of the subject in a single burst of oscillations having a duration equal to the time t o ; and c) selecting a peak power of treatment at least equal to said particular peak power and a duration of the treatment bursts at most equal to the time t o .
Claim 2
Independent Claim
211 words
A method of effecting an ultra-high-speed hyperthermia treatment of a region of a subject located at a known depth within the body, with compressional wave energy derived from ultrasonic transducer means for applying to said region a focussed beam transmitted in the form of periodic bursts of oscillations having a predetermined frequency and a predetermined peak power, each burst having a predetermined duration and the successive bursts being separated by time intervals, said method comprising the steps of: a) effecting tests with said ultrasonic transducer means on a target located at said depth within the body for determining the curve of temperature increase of said target as a function of the time of application of said compressional wave energy, said curve having a quasi-linear portion which starts at time zero and ends at a time t o ; b) determining the particular peak power of said burst of oscillations which will provide at least a substantial destruction of said region of the subject in a single burst of oscillations having a duration equal to the time t o ; and c) selecting a peak power of treatment at least equal to said particular peak power and a duration of the treatment bursts at most equal to the time t o .
Claim 3
Dependent Claim
37 words
The method of claim 1, wherein said frequency is adjusted to be about equal to 1 Mhz and an electric peak power is adjusted such that at least 10 Kw is applied to said ultrasonic transducer means.
Claim 4
Dependent Claim
38 words
The method of claim 1, wherein said frequency is adjusted to be between 1.5 and 3 Mhz and an electric peak power adjusted to be between 2 Kw and 5 Kw is applied to said ultrasonic transducer means.
Claim 5
Dependent Claim
38 words
The method of claim 1, wherein said frequency is adjusted to be about equal to 6 Mhz and an electric peak power adjusted to be about between 100 to 1000 watts is applied to said ultrasonic transducer means.
Claim 6
Dependent Claim
37 words
The method of claim 1, wherein said frequency is adjusted to be about equal to 1 Mhz and an electric power peak adjusted to range between 10 to 20 Kw is applied to said ultrasonic transducer means.
Claim 7
Dependent Claim
17 words
The method of claim 1, wherein said duration is adjusted to be between 0.5 and 3 seconds.
Claim 8
Dependent Claim
17 words
The method of claim 1, wherein said duration is adjusted to be between 0.01 and 1 second.
Claim 9
Dependent Claim
19 words
The method of claim 1, wherein said intervals are adjusted to each equal at least ten times said duration.
Claim 10
Dependent Claim
23 words
The method of claim 1, wherein said duration is adjusted to be about equal to one half of the time t o .
Claim 11
Dependent Claim
178 words
The method of claim 1, wherein said transducer means has a predetermined focal length, a circular transmitting surface and a circular focal spot having first and second predetermined respective diameters, said method comprising the further steps of: d) calculating, as a function of said frequencies and for a plurality of different focal lengths and a peak power of said compressional wave energy equalling 1 Kw, tables of the global concentration factor, k, of the focused beam, where k=k a ×k g , k a being the attenuation factor of the compressional wave energy along the beam path between said transmitting surface and said focal spot and k g being the ratio between said first and second diameters; e) selecting from said plurality of different focal lengths the focal length value which is nearer from the depth of said region and, for said nearer value, selecting from the table the maximum value of said global concentration factor, said maximum value corresponding in the table to a particular frequency; f) selecting a frequency of treatment substantially equalling said particular frequency.
Claim 12
Dependent Claim
192 words
The method of claim 10, wherein said tables further comprise calculated values of the temperature rise per unit of time of a region of a subject to which said compressional wave energy is applied and said method comprises the further steps of: g) determining on the basis of different values of the time of lethal exposure of animal or human living tissues to heat, as a function of the temperature which said tissues are brought to, the value of the temperature rise per unit of time to which the tissues should be subjected for destroying them in the duration of the treatment burst which has been selected in step c); and h) calculating the ratio between the value of the temperature rise per unit of time which has been calculated in step g) and the value of the temperature rise per unit of time which is given by the table for the focal length selected in step e) and the particular frequency selected in step f) and wherein the determination of the particular peak power is step b) is carried out by multiplying 1 Kw by the ratio calculated in step h).
Claim 13
Dependent Claim
51 words
The method of claim 10, wherein said transmission surface is selected to have a diameter of 300 mm, said focal spot is selected to have a diameter of 1.5 mm, said focal distance is selected to be 300 mm and said path is selected to have an aperture angle of 60°.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-10-10 | 1998-04-11 | 1998-10-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-10-10 | 2002-04-11 | 2002-10-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-10-10 | 2006-04-11 | 2006-10-11 | $7700.00 | Window Closed / Lapsed |