US5324518A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Implantable structure for containing substances for delivery to a body
Assignee: Biosynthesis Inc
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Filing: 1992-03-30
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Granted: 1994-06-28
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Expires: 2012-03-30
Abstract
Abstract An implantable structure for incorporation into the tissues of a body is provided which retains therein fluid substances or biological substances which produce, or cause to be produced, biochemicals deliverable to the body. The implantable structure is configured to provide insertion and removal of substances therefrom as needed. The implantable structure generally comprises a porous outer member configured to encourage ingrowth of vascularized tissue therethrough, and an inner member of selectively permeable material providing interior space for inserting substances therein and which is structured to prevent ingrowth of tissue therethrough. The inner member is capable of providing immunoisolation to the substances therein as required.
Inventors
- 👤 Jeffrey L. Orth
- 👤 Richard E. Hoffer
- 👤 Philip M. Triolo
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:30
CPC Classifications
A; A61; A61M; A61M39/00; A61M39/02; A61M39/0208; A61B; A61B5/00; A61B5/145; A61B5/14532
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
172 words
Implantable structure for incorporation into the body tissues of an animal to provide administration of substances from said implantable structure to said body tissues comprising: an outer member of porous synthetic material, the pores of said synthetic material being sized from about 60 microns to about 500 microns to provide ingrowth of vascularized connective tissue therethrough to effect incorporation of said implantable structure into said body tissues; an inner member of selectively permeable porous material positioned within said outer member and structured to provide immunoisolation to substances containable within said inner member, the pores of said selectively permeable material being sized to provide movement of macromolecules therethrough while preventing ingrowth of tissue therethrough and having a pore size of from about 30,000 Daltons to about 25 microns; an inner space formed within said inner member for placement of substances therein; and port means associated with said outer member and said inner member, said port means being in communication with said inner space to transport said substances to and from said inner space.
Claim 2
Dependent Claim
172 words
Implantable structure for incorporation into the body tissues of an animal to provide administration of substances from said implantable structure to said body tissues comprising: an outer member of porous synthetic material, the pores of said synthetic material being sized from about 60 microns to about 500 microns to provide ingrowth of vascularized connective tissue therethrough to effect incorporation of said implantable structure into said body tissues; an inner member of selectively permeable porous material positioned within said outer member and structured to provide immunoisolation to substances containable within said inner member, the pores of said selectively permeable material being sized to provide movement of macromolecules therethrough while preventing ingrowth of tissue therethrough and having a pore size of from about 30,000 Daltons to about 25 microns; an inner space formed within said inner member for placement of substances therein; and port means associated with said outer member and said inner member, said port means being in communication with said inner space to transport said substances to and from said inner space.
Claim 3
Dependent Claim
28 words
The implantable structure of claim 1 wherein said porous synthetic material of said outer member has irregularly shaped and sized pores defining a tortuous pathway through said material.
Claim 4
Dependent Claim
76 words
The implantable structure of claim 2 wherein said outer member has a first end and a second end, wherein said inner member has a first end and a second end, said first end and said second end of said outer member being aligned with said first end and said second end of said inner member, respectively, and said port means being secured in association with said first ends of said outer member and said inner member.
Claim 5
Dependent Claim
21 words
The implantable structure of claim 3 wherein said second ends of said of outer member and said inner member are closed.
Claim 6
Dependent Claim
24 words
The implantable structure of claim 4 further comprising glucose sensor means positionable within said inner space for evaluating extant glucose levels within said structure.
Claim 7
Dependent Claim
18 words
The implantable structure of claim 2 wherein said port means comprises an inlet port and an outlet port.
Claim 8
Dependent Claim
30 words
The implantable structure of claim 6 further including a filter positioned relative to said outlet port, said filter having a pore size of about 1 micron to about 25 microns.
Claim 9
Dependent Claim
37 words
The implantable structure of claim 7 wherein said inner member comprises a plurality of tubules configured to provide movement of said substances therebetween, said tubules being in fluid communication with said inlet port and said outlet port.
Claim 10
Dependent Claim
29 words
The implantable structure of claim 8 wherein said outer member comprises a plurality of sheets of porous synthetic material having spaces formed therein for positioning said tubules relative thereto.
Claim 11
Dependent Claim
43 words
The implantable structure of claim 9 further comprising an outer housing formed of porous synthetic material into which said outer member and said inner member are positionable, said pores of said outer housing being sized to provide ingrowth of vascularized connective tissue therethrough.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-06-27 | 1997-12-27 | 1998-06-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-06-27 | 2001-12-27 | 2002-06-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-06-27 | 2005-12-27 | 2006-06-28 | $7700.00 | Window Closed / Lapsed |