US5296583A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Calcification-resistant synthetic biomaterials
Assignee: University of Michigan-Ann Arbor
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Filing: 1992-07-09
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Granted: 1994-03-22
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Expires: 2012-07-09
Abstract
Abstract Synthetic biomaterials are provided with irreversibly bound amino diphosphonate, polyphosphonate, or other anticalcification agent to prevent in vivo calcification. Such biomaterials include biocompatible elastomers such as polyurethane and/or polydimethylsiloxane, and the like which are intended for invasive, or in-dwelling use in a human or animal body. Illustratively, reaction conditions utilizing bi- or polyfunctional epoxides result in epoxide bridge incorporation of the anticalcification agent to the biomaterial elastomer.
Inventors
- 👤 Robert J. Levy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 00:33
CPC Classifications
C; C08; C08G; C08G59/00; C08G59/14; C08G59/1433; C08G59/1488; A; A61; A61L; A61L27/00; A61L27/14; A61L27/18; A61L27/50; A61L27/54; A61L33/00; A61L33/0005; A61L33/0011; C08L; C08L101/00; C08L101/02; A61L2400/00; A61L2400/02
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
47 words
A method of making a calcification-resistant bicompatible polymeric material comprising the steps of: forming a monoadduct of a polyphosphonate anticalcification agent and a reactive polyfunctional epoxide; adding the monoadduct to a prepolymer base of a biocompatible copolymer; adding the second component of the biocompatible copolymer; and polymerizing.
Claim 2
Independent Claim
47 words
A method of making a calcification-resistant bicompatible polymeric material comprising the steps of: forming a monoadduct of a polyphosphonate anticalcification agent and a reactive polyfunctional epoxide; adding the monoadduct to a prepolymer base of a biocompatible copolymer; adding the second component of the biocompatible copolymer; and polymerizing.
Claim 3
Dependent Claim
11 words
The method of claim 1 wherein the biocompatible copolymer is polyurethane.
Claim 4
Dependent Claim
18 words
The method of claim 2 wherein the prepolymer base is tetramethylene glycol and the second component is diisocyanate.
Claim 5
Dependent Claim
22 words
The method of claim 1 wherein the polyphosphonate is selected from the group consisting of aminopropanehydroxydiphosphonate, ethanehydroxydiphosphonate, aminomethyltriphosphonic acid, and butylpentaphosphonic acid.
Claim 6
Dependent Claim
29 words
The method of claim 1 wherein the polyfunctional epoxide is selected from the group consisting of diglycidyl butanediol ether, ethanediol diglycidyl ether, butanediol diglycidyl ether, and polyglycerol polyglycidyl ethers.
Claim 7
Independent Claim
50 words
A method of making a calcification-resistant polymeric material comprising the steps of: forming a solution of a polyphosphonate anticalcification agent and a reactive polyfunctional epoxide in a solvent; adding to the solution a prepolymerized biocompatible polymer which is soluble in the solvent to form a mixture; and polymerizing the mixture.
Claim 8
Independent Claim
50 words
A method of making a calcification-resistant polymeric material comprising the steps of: forming a solution of a polyphosphonate anticalcification agent and a reactive polyfunctional epoxide in a solvent; adding to the solution a prepolymerized biocompatible polymer which is soluble in the solvent to form a mixture; and polymerizing the mixture.
Claim 9
Dependent Claim
22 words
The method of claim 6 wherein the polyphosphonate is selected from the group consisting of aminopropanehydroxydiphosphonate, ethanehydroxydiphosphonate, aminomethyltriphosphonic acid, and butylpentaphosphonic acid.
Claim 10
Dependent Claim
29 words
The method of claim 6 wherein the polyfunctional epoxide is selected from the group consisting of diglycidyl butanediol ether, ethanediol diglycidyl ether, butanediol diglycidyl ether, and polyglycerol polyglycidyl ethers.
References Cited (Backward Citations)
US4259472A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1997-03-21 | 1997-09-20 | 1998-03-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-03-21 | 2001-09-20 | 2002-03-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-03-21 | 2005-09-20 | 2006-03-22 | $7700.00 | Window Closed / Lapsed |