US5281419A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Biodegradable drug delivery system for the prevention and treatment of osteomyelitis
Assignee: Thomas Jefferson University
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Filing: 1992-09-28
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Granted: 1994-01-25
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Expires: 2012-09-28
Abstract
Abstract An antibiotic impregnated fracture fixation device and antibiotic impregnated drug delivery polymer are provided. In a preferred embodiment, a homogenous mixture of thermally melted poly(lactic) acid and at least one antibiotic and/or antibacterial agent are employed.
Inventors
- 👤 Rocky S. Tuan
- 👤 Sheldon S. Lin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 02:23
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/14; A61L31/16; A61L31/04; A61L31/06; A61L2300/00; A61L2300/40; A61L2300/404; A61L2300/406
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
38 words
A device for treating a fractured bone, comprising a fracture fixation device comprising a pre-formed composite consisting essentially of a homogenous mixture of thermally melted poly(lactic) acid and at least one antibiotic and/or antibacterial agent selected quinoline antibiotics.
Claim 2
Independent Claim
38 words
A device for treating a fractured bone, comprising a fracture fixation device comprising a pre-formed composite consisting essentially of a homogenous mixture of thermally melted poly(lactic) acid and at least one antibiotic and/or antibacterial agent selected quinoline antibiotics.
Claim 3
Dependent Claim
15 words
The fracture fixation device of claim 1 wherein said antibiotic and/or antibacterial agent comprises ciprofloxacin.
Claim 4
Dependent Claim
34 words
The fracture fixation device of claim 2 wherein said poly(lactic)acid has an average molecular size ranging from between about 2 to 100 kDa and ciprofloxacin comprises about 5 to 30% (w/w) of said device.
Claim 5
Dependent Claim
29 words
The fracture fixation device of claim 3 wherein said poly(lactic) acid has an average molecular size of about 2 kDa and iprofloxacin comprises about 10% (w/w) of said device.
Claim 6
Dependent Claim
29 words
The fracture fixation device of claim 3 wherein said poly(lactic) acid has an average molecular size of about 50 kDa and ciprofloxacin comprises about 30% (w/w) of said device.
Claim 7
Dependent Claim
28 words
The fracture fixation device of claim 2 further comprising a plate, rod, or pin upon which said composite of thermally melted poly(lactic) acid and ciprofloxacin is concentrically layered.
Claim 8
Dependent Claim
15 words
The fracture fixation device of claim 6 wherein the plate, rod, or pin is metallic.
Claim 9
Dependent Claim
17 words
The fracture fixation device of claim 1 wherein the composite is in the form of a rod.
Claim 10
Dependent Claim
18 words
The fracture fixation device of claim 1 wherein the homogenous mixture is in the form of a plate.
Claim 11
Dependent Claim
18 words
The fracture fixation device of claim 1 wherein the homogenous mixture is in the form of a pin.
Claim 12
Independent Claim
44 words
A device for treating a fractured bone, comprising a fracture fixation device consisting essentially of a homogenous mixture of thermally melted poly(lactic) acid having an average molecular size of from 50-100 kDA and ciprofloxacin selected from the group consisting of quinoline and aminoglycoside antibiotics.
Claim 13
Independent Claim
44 words
A device for treating a fractured bone, comprising a fracture fixation device consisting essentially of a homogenous mixture of thermally melted poly(lactic) acid having an average molecular size of from 50-100 kDA and ciprofloxacin selected from the group consisting of quinoline and aminoglycoside antibiotics.
Claim 14
Dependent Claim
17 words
The fracture fixation device of claim 11 wherein the device is in the form of a rod.
Claim 15
Dependent Claim
17 words
The fracture fixation device of claim 11 wherein the device is in the form of a plate.
Claim 16
Dependent Claim
17 words
The fracture fixation device of claim 11 wherein the device is in the form of a pin.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-01-24 | 1997-07-26 | 1998-01-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-01-24 | 2001-07-26 | 2002-01-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-01-24 | 2005-07-26 | 2006-01-25 | $7700.00 | Window Closed / Lapsed |