US5280109A
Expired / Lapsed
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Isolated, large latent complexes of TGF-β2 and TGF-β3, and new binding protein for latent form TGF-β1, TGF-β2 and TGF-β3 LTBP-2
Assignee: Ludwig Cancer Research
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Filing: 1992-01-27
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Granted: 1994-01-18
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Expires: 2012-01-27
Abstract
Abstract The invention relates to large latent complexes of TGF- beta 2 and TGF- beta 3, and methods for isolating these. The complex consists of a dimerized form of TGF- beta 2 or TGF- beta 3, the appropriate latency associated peptide, and the latent TGF- beta 1 binding protein, referred to as LTBP. Also described is a protein which binds to all of TGF- beta 1, TGF- beta 2 and TGF- beta 3, but is immunologically distinct from LTBP, referred to as LTBP-2.
Inventors
- 👤 Kohei Miyazono
- 👤 Carl-Henrik Heldin
- 👤 Anders Olofsson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:58
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/475; C07K14/495
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
45 words
Isolated large latent TGF-β complex consisting of: (i) latent, TGF-β1 binding protein; (ii) dimerized, beta latency associated peptide linked to said latent TGF-β1 binding protein via a disulphide bond, and (iii) dimerized TGF-β2 or dimerized TGF-β3 non-covalently associated with said dimerized beta latency associated peptide.
Claim 2
Dependent Claim
45 words
Isolated large latent TGF-β complex consisting of: (i) latent, TGF-β1 binding protein; (ii) dimerized, beta latency associated peptide linked to said latent TGF-β1 binding protein via a disulphide bond, and (iii) dimerized TGF-β2 or dimerized TGF-β3 non-covalently associated with said dimerized beta latency associated peptide.
Claim 3
Dependent Claim
15 words
The isolated large latent TGF-β complex of claim 1, wherein said complex contains dimerized TGF-β2.
Claim 4
Dependent Claim
15 words
The isolated large latent TGF-β complex of claim 1, wherein said complex contains dimerized TGF-β3.
References Cited (Backward Citations)
WO1991013152A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-01-17 | 1997-07-19 | 1998-01-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-01-17 | 2001-07-19 | 2002-01-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-01-17 | 2005-07-19 | 2006-01-18 | $7700.00 | Window Closed / Lapsed |