US5273751A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Composition for preventing clouding of paosterior capsule after extracapsular cataract eye surgery and method of performing cataract surgery
Assignee: Individual
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Filing: 1991-10-09
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Granted: 1993-12-28
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Expires: 2011-10-09
Abstract
Abstract The present invention relates to compositions for killing undifferentiated epithelial cells during cataract surgery on an eye to prevent posterior capsule clouding after the surgery and to a method for performing cataract surgery on an eye including injecting a cell-killing substance between the anterior capsule and the natural lens prior to removing the natural lens from the eye. The cell-killing substance is preferably an acid or base adjusted aqueous solution having a pH in the range between about 1.0 to below 6.5 or about above 7.5 to 14.0; or a hypotonic solution having a salinity less than 0.9% or a pH adjusted hypotonic solution having a salinity less than 0.9% and a pH either below 6.5 or above 7.5. The compositions of the present invention also incorporates a viscoelastic material, a dye or a mixture thereof, in combination with the cell-killing substance.
Inventors
- 👤 Seymour Dubroff
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 03:29
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/71; A61M1/77; A61M2210/00; A61M2210/06; A61M2210/0612
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
57 words
A composition for administration between an anterior capsule and a lens comprising a pH adjusted solution having a pH in a range between approximately 1.0 to below 6.5 or a pH in a range between approximately above 7.5 to 14, a visually apparent amount of a dye and 0.5 to 5.0% by weight of a viscoelastic material.
Claim 2
Dependent Claim
57 words
A composition for administration between an anterior capsule and a lens comprising a pH adjusted solution having a pH in a range between approximately 1.0 to below 6.5 or a pH in a range between approximately above 7.5 to 14, a visually apparent amount of a dye and 0.5 to 5.0% by weight of a viscoelastic material.
Claim 3
Dependent Claim
16 words
The composition of claim 1 wherein said solution comprises a mixture of water and an acid.
Claim 4
Dependent Claim
10 words
The composition of claim 2 wherein said acid is HCl.
Claim 5
Dependent Claim
16 words
The composition of claim 1 wherein said solution comprises a mixture of water and a base.
Claim 6
Dependent Claim
10 words
The composition of claim 4 wherein said base is NaOH.
Claim 7
Dependent Claim
10 words
The composition of claim 1 wherein said dye is blue.
Claim 8
Dependent Claim
18 words
The composition of claim 1 wherein said visually apparent amount of said dye is 0.1 to 10 ppm.
Claim 9
Dependent Claim
21 words
The composition of claim 1 wherein said solution has a pH ranging between 5.8 to 6.2 or between 8.0 to 8.4.
Claim 10
Dependent Claim
32 words
A composition for administration between an anterior capsule and a lens comprising 0.5 to 5.0% by weight of a viscoelastic material and a cell-killing substance having properties to kill undifferentiated epithelial cells.
Claim 11
Dependent Claim
32 words
A composition for administration between an anterior capsule and a lens comprising 0.5 to 5.0% by weight of a viscoelastic material and a cell-killing substance having properties to kill undifferentiated epithelial cells.
Claim 12
Dependent Claim
9 words
The composition of claim 9 additionally comprising a dye.
Claim 13
Dependent Claim
25 words
A composition for administration between an anterior capsule and a lens comprising a dye and a cell-killing substance having properties to kill undifferentiated epithelial cells.
Claim 14
Dependent Claim
25 words
A composition for administration between an anterior capsule and a lens comprising a dye and a cell-killing substance having properties to kill undifferentiated epithelial cells.
Claim 15
Dependent Claim
50 words
A composition for administration into an eye between an anterior capsule and a natural lens comprising a hypotonic solution having a salinity less than 0.9% and having properties to kill undifferentiated epithelial cells, a visually apparent amount of a dye and 0.5 to 5.0% by weight of a viscoelastic material.
Claim 16
Dependent Claim
50 words
A composition for administration into an eye between an anterior capsule and a natural lens comprising a hypotonic solution having a salinity less than 0.9% and having properties to kill undifferentiated epithelial cells, a visually apparent amount of a dye and 0.5 to 5.0% by weight of a viscoelastic material.
Claim 17
Dependent Claim
16 words
The composition of claim 12 wherein said solution has a pH below 6.5 or above 7.5.
Claim 18
Dependent Claim
24 words
The composition of claim 12 wherein said solution has a pH in the range from between 5.8 to 6.2 or between 8.0 to 8.4.
Claim 19
Dependent Claim
14 words
The composition of claim 12 wherein said solution has a salinity less than 0.6%.
Claim 20
Independent Claim
118 words
A system for preventing clouding of the posterior capsule after extracapsular cataract extraction by killing lens epithelial cells while the natural lens remains in the capsule characterized in a syringe having an injection chamber filled with a substance having properties to kill lens epithelial cells and 0.5 to 5.0% by weight of a viscoelastic material, a piston movably disposed in said injection chamber, and a needle communicating with said injection chamber and having a configuration to inject said substance between the anterior capsule and the natural lens through an open distal end of the needle when said piston is moved in said injection chamber whereby the epithelial cells are killed while the natural lens remains in the capsule.
Claim 21
Independent Claim
118 words
A system for preventing clouding of the posterior capsule after extracapsular cataract extraction by killing lens epithelial cells while the natural lens remains in the capsule characterized in a syringe having an injection chamber filled with a substance having properties to kill lens epithelial cells and 0.5 to 5.0% by weight of a viscoelastic material, a piston movably disposed in said injection chamber, and a needle communicating with said injection chamber and having a configuration to inject said substance between the anterior capsule and the natural lens through an open distal end of the needle when said piston is moved in said injection chamber whereby the epithelial cells are killed while the natural lens remains in the capsule.
Claim 22
Dependent Claim
27 words
The system as recited in claim 16 wherein said substance comprises a solution having a salinity less than 0.9% to kill the epithelial cells by osmotic pressure.
Claim 23
Dependent Claim
33 words
The system as recited in claim 17 wherein said solution has a pH in the range between approximately 1.0 to below 6.5 or a pH in a range between approximately 7.5 to 14.
Claim 24
Dependent Claim
21 words
The system as recited in claim 16 wherein the injection chamber is additionally filled with a visually apparent amount of dye.
Claim 25
Dependent Claim
35 words
The system as recited in claim 16 further characterized by a viscoelastic material placed in the anterior chamber of the eye preventing any of the substance escaping from the capsule from reaching the corneal endothelium.
Claim 26
Independent Claim
115 words
A system for preventing clouding of the posterior capsule after extracapsular cataract extraction by killing lens epithelial cells while the natural lens remains in the capsule characterized in a syringe having an injection chamber filled with a substance having properties to kill lens epithelial cells and a visually apparent amount of dye, a piston movably disposed in said injection chamber, and a needle communicating with said injection chamber and having a configuration to inject said substance between the anterior capsule and the natural lens through an open distal end of the needle when said piston is moved in said injection chamber whereby the epithelial cells are killed while the natural lens remains in the capsule.
Claim 27
Independent Claim
115 words
A system for preventing clouding of the posterior capsule after extracapsular cataract extraction by killing lens epithelial cells while the natural lens remains in the capsule characterized in a syringe having an injection chamber filled with a substance having properties to kill lens epithelial cells and a visually apparent amount of dye, a piston movably disposed in said injection chamber, and a needle communicating with said injection chamber and having a configuration to inject said substance between the anterior capsule and the natural lens through an open distal end of the needle when said piston is moved in said injection chamber whereby the epithelial cells are killed while the natural lens remains in the capsule.
Claim 28
Dependent Claim
27 words
The system as recited in claim 21 wherein said substance comprises a solution having a salinity less than 0.9% to kill the epithelial cells by osmotic pressure.
Claim 29
Dependent Claim
33 words
The system as recited in claim 22 wherein said solution has a pH in the range between approximately 1.0 to below 6.5 or a pH in a range between approximately 7.5 to 14.
Claim 30
Dependent Claim
35 words
The system as recited in claim 21 further characterized by a viscoelastic material placed in the anterior chamber of the eye preventing any of the substance escaping from the capsule from reaching the corneal endothelium.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-12-27 | 1997-06-28 | 1997-12-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-12-27 | 2001-06-28 | 2001-12-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-12-27 | 2005-06-28 | 2005-12-28 | $7700.00 | Window Closed / Lapsed |