US5264214A
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Composition for bone repair
Assignee: Angiodevice International GmbH
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Filing: 1992-08-14
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Granted: 1993-11-23
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Expires: 2012-08-14
Abstract
Abstract Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer.
Inventors
- 👤 Woonza Rhee
- 👤 Donald G. Wallace
- 👤 Alan S. Michaels
- 👤 Ramon A. Burns, Jr.
- 👤 Louis Fries
- 👤 Frank DeLustro
- 👤 Hanne Bentz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:02
CPC Classifications
C; C08; C08L; C08L89/00; C08L89/04; C08L89/06; A; A61; A61L; A61L24/00; A61L24/04; A61L24/10; A61L24/102; A61L27/00; A61L27/14; A61L27/22; A61L27/24; A61L27/26; A61L27/28; A61L27/34; A61L27/40; A61L27/44; A61L27/50; A61L27/54; A61L31/00; A61L31/04; A61L31/041; A61L31/043; A61L31/044; A61L31/08; A61L31/10; A61L31/12; A61L31/125; C08H; C08H1/00; C08H1/06; C09; C09J; C09J189/00; C09J189/04; C09J189/06; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61F2/07; A61F2310/00; A61F2310/00005; A61F2310/00365; A61L2300/00; A61L2300/40; A61L2300/412; A61L2300/414; A61L2300/60; A61L2300/602; A61L2430/00; A61L2430/02; A61L2430/16; C08L2666/00; C08L2666/02
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
32 words
A composition suitable for repair of bone defects, which comprises: collagen chemically conjugated to a synthetic hydrophilic polymer; a suitable particulate material; and a sufficient amount of a fluid pharmaceutically acceptable carrier.
Claim 2
Dependent Claim
32 words
A composition suitable for repair of bone defects, which comprises: collagen chemically conjugated to a synthetic hydrophilic polymer; a suitable particulate material; and a sufficient amount of a fluid pharmaceutically acceptable carrier.
Claim 3
Dependent Claim
13 words
The composition of claim 1 wherein said collagen is reconstituted atelopeptide fibrillar collagen.
Claim 4
Dependent Claim
20 words
The composition of claim 1 wherein said polymer is monomethyl-polyethylene glycol having a weight average molecular weight of about 5,000.
Claim 5
Dependent Claim
22 words
The composition of claim 3 wherein said monomethyl-polyethylene glycol is chemically conjugated to 10-50% of the available lysine residues on said collagen.
Claim 6
Dependent Claim
41 words
The composition of claim 1 wherein said suitable particulate material comprises fibrillar crosslinked collagen, gelatin beads, polytetrafluoroethylene beads, silicone rubber beads, hydrogel beads, silicon carbide beads, glass beads, hydroxyapatite particles, tricalcium phosphate particles, or mixtures of hydroxyapatite and tricalcium phosphate particles.
Claim 7
Dependent Claim
35 words
The composition of claim 5 wherein said particulate material comprises hydroxyapatite particles, tricalcium phosphate particles, or mixtures of hydroxyapatite and tricalcium phosphate particles having an average diameter of about 1 to 20 microns in diameter
Claim 8
Dependent Claim
60 words
The composition of claim 31 which further comprises a tissue growth-promoting amount of epidermal growth factor, transforming growth factor-α, transforming growth factor-β, transforming growth factor-β1, transforming growth factor-β2, platelet-derived growth factor-AA, platelet-derived growth factor-AB, platelet-derived growth factor-BB, acidic fibroblast growth factor, basic fibroblast growth factor, insulin-like growth factors, interleukins, colony stimulating factors, erythropoietin, nerve growth factor, interferons, and osteogenic factors.
Claim 9
Dependent Claim
35 words
A composition suitable for repair of bone defects in stress-bearing bone, which comprises: collagen chemically conjugated to a synthetic hydrophilic polymer; and a suitable particulate material in an amount sufficient to provide a rigid composition.
Claim 10
Dependent Claim
35 words
A composition suitable for repair of bone defects in stress-bearing bone, which comprises: collagen chemically conjugated to a synthetic hydrophilic polymer; and a suitable particulate material in an amount sufficient to provide a rigid composition.
Claim 11
Dependent Claim
13 words
The composition of claim 8 wherein said collagen is reconstituted atelopeptide fibrillar collagen.
Claim 12
Dependent Claim
18 words
The composition of claim 38 wherein said polymer is monomethyl-polyethylene glycol having a molecular weight of about 5,000.
Claim 13
Dependent Claim
22 words
The composition of claim 10 wherein said monomethyl-polyethylene glycol is chemically conjugated to 10-50% of the available lysine residues on said collagen.
Claim 14
Dependent Claim
41 words
The composition of claim 8 wherein said suitable particulate material comprises fibrillar crosslinked collagen, gelatin beads, polytetrafluoroethylene beads, silicone rubber beads, hydrogel beads, silicon carbide beads, glass beads, hydroxyapatite particles, tricalcium phosphate particles, or mixtures of hydroxyapatite and tricalcium phosphate particles.
Claim 15
Dependent Claim
35 words
The composition of claim 12 wherein said particulate material comprises hydroxyapatite particles, tricalcium phosphate particles, or mixtures of hydroxyapatite and tricalcium phosphate particles having an average diameter of about 1 to 20 microns in diameter.
Claim 16
Dependent Claim
60 words
The composition of claim 8 which further comprises a tissue growth-promoting amount of epidermal growth factor, transforming growth factor-α, transforming growth factor-β, transforming growth factor-β1, transforming growth factor-β2, platelet-derived growth factor-AA, platelet-derived growth factor-AB, platelet-derived growth factor-BB, acidic fibroblast growth factor, basic fibroblast growth factor, insulin-like growth factors, interleukins, colony stimulating factors, erythropoietin, nerve growth factor, interferons, and oseogenic factors.
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