US5230334A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method and apparatus for generating localized hyperthermia
Assignee: Summit Technology Inc
•
Filing: 1992-01-22
•
Granted: 1993-07-27
•
Expires: 2012-01-22
Abstract
Abstract Ultrasound generating methods and apparatus are disclosed for producing controlled, localized hyperthermia in a selected heating zone of human tissue, utilizing at least one ultrasound transducer, preferably driven by sinusoidal excitation signals in a continuous wave or quasi-continuous wave mode to generate ultrasound. The temperature in the heated zone can be controlled by selecting the power, duration and frequency of the ultrasound. The penetration of the ultrasound, and thus the depth and volume of the target zone, can be controlled by selecting the excitation frequencies so to confine the absorption of the ultrasound beam in the target tissue. The invention is particularly useful in inducing controlled collagen shrinkage in corneal tissue to effective thermokeratoplasty (heat induced modification of the shape of the cornea).
Inventors
- 👤 Peter J. Klopotek
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:34
CPC Classifications
A; A61; A61N; A61N7/00; A61F; A61F9/00; A61F9/007; A61F9/0079; A61B; A61B8/00; A61B8/42; A61B8/4272; A61F9/008; A61F2009/00842; A61F2009/00853; A61F2009/00861; A61F2009/00872; A61F9/009
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
92 words
Apparatus for generating controlled hyperthermia in a selected hyperthermia zone in a target region of tissue in a body, the apparatus comprising: ultrasound generating means for generating ultrasound; propagation means, in acoustical communication with said ultrasound generating means, for directing the ultrasound into said target region; and frequency control means for selecting a plurality of frequencies of said ultrasound, from a range of about 20 MHz to 500 MHz, such that said plurality of frequencies constructively interfere within said tissue to deposit acoustic energy at a selected location within said target region.
Claim 2
Dependent Claim
92 words
Apparatus for generating controlled hyperthermia in a selected hyperthermia zone in a target region of tissue in a body, the apparatus comprising: ultrasound generating means for generating ultrasound; propagation means, in acoustical communication with said ultrasound generating means, for directing the ultrasound into said target region; and frequency control means for selecting a plurality of frequencies of said ultrasound, from a range of about 20 MHz to 500 MHz, such that said plurality of frequencies constructively interfere within said tissue to deposit acoustic energy at a selected location within said target region.
Claim 3
Dependent Claim
24 words
Apparatus according to claim 1 wherein said ultrasound generating means includes an ultrasound transducer for generating ultrasound in response to applied electrical excitation signals.
Claim 4
Dependent Claim
36 words
Apparatus according to claim 2 wherein said ultrasound generating means includes electrical excitation means for generating and applying to said ultrasound transducer said electrical excitation signals having a substantially sinusoidal waveform in a continuous wave mode.
Claim 5
Dependent Claim
17 words
Apparatus according to claim 1 wherein said apparatus further includes focusing means for acoustically focusing said ultrasound.
Claim 6
Dependent Claim
14 words
Apparatus according to claim 1 wherein said propagation means comprises an ultrasound transmitting waveguide.
Claim 7
Dependent Claim
22 words
Apparatus according to claim 5 wherein said propagation means further comprises acoustic coupling means disposed between said waveguide and said target region.
Claim 8
Dependent Claim
24 words
Apparatus according to claim 1 wherein said frequency control means comprises means for sweeping said frequencies of said ultrasound though a selected frequency range.
Claim 9
Independent Claim
77 words
A method for generating controlled hyperthermia in a target region of corneal tissue, the method comprising the steps of: generating a series of waves of ultrasound having a plurality of frequencies within the range of about 20 MHz to about 500 MHz; propagating said ultrasound into said target region of cornea tissue; and controlling the frequency components of said ultrasound to deposit acoustical energy such that said components constructively interfere in said tissue within said target region.
Claim 10
Independent Claim
77 words
A method for generating controlled hyperthermia in a target region of corneal tissue, the method comprising the steps of: generating a series of waves of ultrasound having a plurality of frequencies within the range of about 20 MHz to about 500 MHz; propagating said ultrasound into said target region of cornea tissue; and controlling the frequency components of said ultrasound to deposit acoustical energy such that said components constructively interfere in said tissue within said target region.
Claim 11
Dependent Claim
20 words
A method according to claim 8 wherein the step of generating the ultrasound further includes electrically exciting an ultrasound transducer.
Claim 12
Dependent Claim
26 words
A method according to claim 8 wherein the step of generating the ultrasound further comprises generating a series of substantially sinusoidal, continuous waves of said ultrasound.
Claim 13
Dependent Claim
26 words
A method according to claim 8 wherein the step of propagating said ultrasound further comprises the step of acoustically focusing said ultrasound into the target region.
Claim 14
Dependent Claim
30 words
A method according to claim 8 wherein the step of propagating said ultrasound further includes the step of employing an acoustically transmitting waveguide to direct the transmission of said ultrasound.
Claim 15
Dependent Claim
30 words
A method according to claim 12 wherein the step of propagating said ultrasound further includes the step of employing an acoustic coupling element between the waveguide and the target region.
Claim 16
Dependent Claim
27 words
A method according to claim 8 wherein the step of controlling the frequency components further includes the step of sweeping through a selected range of ultrasound frequencies.
Claim 17
Dependent Claim
36 words
A method according to claim 8 wherein the method further includes the step of controlling the target region size and volume of the hyperthermia zone within the cornea to induce controlled collagen shrinkage and effect keratoplasty.
Claim 18
Independent Claim
94 words
A method of performing corneal thermokeratoplasty, the method of comprising the steps of: generating a series of waves of ultrasound ranging from about 20 MHz to about 500 MHz; propagating said ultrasound toward a cornea; focusing said ultrasound within the collagen region of said cornea; and varying the frequency of said ultrasound to provide a plurality of frequencies and thereby generate a constructive interference hyperthermia zone within the collagen region at a selected location whereby, the collagenous tissue shrinks in a controlled manner in said hyperthermia zone, thereby modifying the shape of the cornea.
Claim 19
Independent Claim
94 words
A method of performing corneal thermokeratoplasty, the method of comprising the steps of: generating a series of waves of ultrasound ranging from about 20 MHz to about 500 MHz; propagating said ultrasound toward a cornea; focusing said ultrasound within the collagen region of said cornea; and varying the frequency of said ultrasound to provide a plurality of frequencies and thereby generate a constructive interference hyperthermia zone within the collagen region at a selected location whereby, the collagenous tissue shrinks in a controlled manner in said hyperthermia zone, thereby modifying the shape of the cornea.
References Cited (Backward Citations)
SU822407A1
Cited
US4315514A
Cited
US4381007A
Cited
US4461294A
Cited
US4546771A
Cited
US4580559A
Cited
US4907585A
Cited
WO1989006519A2
Cited
US4976709A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-07-26 | 1997-01-25 | 1997-07-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-07-26 | 2001-01-25 | 2001-07-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-07-26 | 2005-01-25 | 2005-07-27 | $7700.00 | Window Closed / Lapsed |