US5229495A
Expired / Lapsed
US
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Substantially pure receptor like TGF-β 1 binding molecules and uses thereof
Assignee: Ludwig Cancer Research
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Filing: 1991-06-18
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Granted: 1993-07-20
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Expires: 2011-06-18
Abstract
Abstract The invention relates to a family of substantially pure, receptor like TGF- beta 1 binding glycoproteins. These molecules are characterized by molecular masses of 160 kd, 70-80 kd, and 30-40 kd as determined by SDS-PAGE, and the ability to bind the TGF- beta 1 molecule. This family of molecules is useful in identifying and/or quantifying TGF- beta 1 in a sample, as well as inhibiting its effect on cells.
Inventors
- 👤 Hidenori Ichijo
- 👤 Kohei Miyazono
- 👤 Lars Ronnstrand
- 👤 Ulf Hellman
- 👤 Christer Wernstedt
- 👤 Carl-Henrik Heldin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:39
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/705; C07K14/71; C07K14/475; C07K14/495; C07K16/00; C07K16/18; C07K16/28; C07K16/2863; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
27 words
Substantially pure, membrane derived receptor like transforming growth factor β1 binding molecule, characterized by a molecular weight of from 35 to 40 kd as determined by SDS-PAGE.
Claim 2
Dependent Claim
27 words
Substantially pure, membrane derived receptor like transforming growth factor β1 binding molecule, characterized by a molecular weight of from 35 to 40 kd as determined by SDS-PAGE.
Claim 3
Dependent Claim
45 words
Method for identifying transforming growth factor β1 binding protein in a sample, comprising contacting said sample with the substantially pure, receptor like binding molecule of claim 1 and determining binding to said binding molecule as a determination of transforming growth factor 1 in said sample.
Claim 4
Dependent Claim
26 words
The substantially pure, membrane derived receptor like transforming growth factor β1 binding molecule of claim 1, comprising the amino acid sequence of SEQ ID NO: 2.
Claim 5
Dependent Claim
26 words
The substantially pure, membrane derived receptor like transforming growth factor β1 binding molecule of claim 1, comprising the amino acid sequence of SEQ ID NO: 3.
Claim 6
Dependent Claim
26 words
The substantially pure, membrane derived receptor like transforming growth factor β1 binding molecule of claim 1, comprising the amino acid sequence of SEQ ID NO: 4.
References Cited (Backward Citations)
WO1991013152A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-07-19 | 1997-01-18 | 1997-07-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-07-19 | 2001-01-18 | 2001-07-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-07-19 | 2005-01-18 | 2005-07-20 | $7700.00 | Window Closed / Lapsed |