US5223427A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hybridomas producing monoclonal antibodies reactive with human tissue-factor glycoprotein heavy chain
Assignee: Scripps Research Institute
•
Filing: 1988-03-09
•
Granted: 1993-06-29
•
Expires: 2008-03-09
Abstract
Abstract Murine hybridomas producing monoclonal antibodies capable of immunoreacting with huTFh and polypeptide analogs are described. Also contemplated are immunologic methods for detecting huTF heavy chain in body fluid, detecting thrombic events in vivo, isolating coagulation factor, and neutralizing VII/VIIa coagulation factor binding in vivo.
Inventors
- 👤 Thomas S. Edgington
- 👤 James H. Morrissey
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:13
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/86; A; A61; A61P; A61P7/00; A61P7/02; C; C07; C07H; C07H21/00; C07K; C07K14/00; C07K14/435; C07K14/745; C07K16/00; C07K16/18; C07K16/36; A61K; A61K39/00; A61K2039/505; A61K38/00; G01N2333/00; G01N2333/435; G01N2333/745; Y; Y10; Y10S; Y10S530/00; Y10S530/808; Y10S530/809
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
40 words
Hybridoma TF8-5G9, said hybridoma characterized as producing antibody molecules that: (a) immunoreact with human tissue factor heavy chain protein, (b) immunoreact with a polypeptide represented by the formula ##STR1## (c) inhibit the ability of human tissue factor to initiate coagulation.
Claim 2
Dependent Claim
40 words
Hybridoma TF8-5G9, said hybridoma characterized as producing antibody molecules that: (a) immunoreact with human tissue factor heavy chain protein, (b) immunoreact with a polypeptide represented by the formula ##STR1## (c) inhibit the ability of human tissue factor to initiate coagulation.
Claim 3
Dependent Claim
46 words
A monoclonal antibody composition comprising antibody molecules produced by hybridoma TF8-5G9, said antibody molecules characterized by: (a) immunoreacting with human tissue factor heavy chain protein, (b) immunoreacting with a polypeptide represented by the formula: ##STR2## (c) inhibiting the ability of human tissue factor to initiate coagulation.
Claim 4
Dependent Claim
46 words
A monoclonal antibody composition comprising antibody molecules produced by hybridoma TF8-5G9, said antibody molecules characterized by: (a) immunoreacting with human tissue factor heavy chain protein, (b) immunoreacting with a polypeptide represented by the formula: ##STR2## (c) inhibiting the ability of human tissue factor to initiate coagulation.
Claim 5
Dependent Claim
42 words
Hybridoma TF9-10H10, said hybridoma characterized as producing antibody molecules that: (a) immunoreact with human tissue factor heavy chain protein, (b) immunoreact with a polypeptide represented by the formula: ##STR3## (c) do not inhibit the ability of human tissue factor to initiate coagulation.
Claim 6
Dependent Claim
42 words
Hybridoma TF9-10H10, said hybridoma characterized as producing antibody molecules that: (a) immunoreact with human tissue factor heavy chain protein, (b) immunoreact with a polypeptide represented by the formula: ##STR3## (c) do not inhibit the ability of human tissue factor to initiate coagulation.
Claim 7
Dependent Claim
48 words
A monoclonal antibody composition comprising antibody molecules produced by hybridoma TF9-10H10, said antibody molecules characterized by: (a) immunoreacting with human tissue factor heavy chain protein, (b) immunoreacting with a polypeptide represented by the formula: ##STR4## and (c) not inhibiting the ability of human tissue factor to initiate coagulation.
Claim 8
Dependent Claim
48 words
A monoclonal antibody composition comprising antibody molecules produced by hybridoma TF9-10H10, said antibody molecules characterized by: (a) immunoreacting with human tissue factor heavy chain protein, (b) immunoreacting with a polypeptide represented by the formula: ##STR4## and (c) not inhibiting the ability of human tissue factor to initiate coagulation.
Claim 9
Dependent Claim
40 words
Hybridoma TF9-5B7, said hybridoma characterized as producing antibody molecules that: (a) immunoreact with human tissue factor heavy chain protein, (b) immunoreact with a polypeptide represented by the formula: ##STR5## (c) inhibit the ability of human tissue factor to initiate coagulation.
Claim 10
Dependent Claim
40 words
Hybridoma TF9-5B7, said hybridoma characterized as producing antibody molecules that: (a) immunoreact with human tissue factor heavy chain protein, (b) immunoreact with a polypeptide represented by the formula: ##STR5## (c) inhibit the ability of human tissue factor to initiate coagulation.
Claim 11
Dependent Claim
46 words
A monoclonal antibody composition comprising antibody molecules produced by hybridoma TF9-5B7, said antibody molecules characterized by: (a) immunoreacting with human tissue factor heavy chain protein, (b) immunoreacting with a polypeptide represented by the formula: ##STR6## (c) inhibiting the ability of human tissue factor to initiate coagulation.
Claim 12
Dependent Claim
46 words
A monoclonal antibody composition comprising antibody molecules produced by hybridoma TF9-5B7, said antibody molecules characterized by: (a) immunoreacting with human tissue factor heavy chain protein, (b) immunoreacting with a polypeptide represented by the formula: ##STR6## (c) inhibiting the ability of human tissue factor to initiate coagulation.
References Cited (Backward Citations)
EP0278776A2
Cited
WO1988009817A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-06-28 | 1996-12-28 | 1997-06-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-06-28 | 2000-12-28 | 2001-06-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-06-28 | 2004-12-28 | 2005-06-29 | $7700.00 | Window Closed / Lapsed |