US5219360A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Mammary prosthesis fill and method of making same
Assignee: Genzyme Corp
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Filing: 1991-05-10
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Granted: 1993-06-15
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Expires: 2011-05-10
Abstract
Abstract A surgical mammary prosthesis containing a liquid-gel of cross-linked hyaluronic acid (hylan) inside a medical grade elastomer, and a method of making a prosthesis containing such a liquid-gel. Because the gel used in the invention contains a nontoxic, nonantigenic, noninflammatory, biodegradable natural substance, problems attributed to or associated with previous silicone gel filled prostheses as a result of prosthesis rupture or leakage or "bleed" are avoided.
Inventors
- 👤 Nicholas G. Georgiade
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:29
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/12; A61L; A61L27/00; A61L27/14; A61L27/20; A61L2430/00; A61L2430/04
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
87 words
An implantable mammary prosthesis to augment natural breast tissue comprising: (a) a hollow shell formed of a flexible elastomeric envelope, said shell having an inner volume and an exterior surface, said prosthesis adapted to be surgically implanted in a human breast so that the envelope retains a desired shape when said inner volume is filled by a liquid-gel substance; (b) said envelope having a means for filling the envelope inner volume with said liquid-gel; and (c) said liquid-gel filling said inner volume is a cross-linked hyaluronic acid.
Claim 2
Dependent Claim
87 words
An implantable mammary prosthesis to augment natural breast tissue comprising: (a) a hollow shell formed of a flexible elastomeric envelope, said shell having an inner volume and an exterior surface, said prosthesis adapted to be surgically implanted in a human breast so that the envelope retains a desired shape when said inner volume is filled by a liquid-gel substance; (b) said envelope having a means for filling the envelope inner volume with said liquid-gel; and (c) said liquid-gel filling said inner volume is a cross-linked hyaluronic acid.
Claim 3
Dependent Claim
16 words
A mammary prosthesis according to claim 1, wherein the hyaluronic acid liquid-gel has aldehyde cross-linking groups.
Claim 4
Dependent Claim
18 words
A mammary prosthesis according to claim 1, further comprising hyaluronan placed on the exterior surface of the envelope.
Claim 5
Dependent Claim
73 words
An implantable mammary prosthesis to augment natural breast tissue, said prosthesis having a a hollow shell formed of a medical grade elastomer, said hollow shell having an outer layer and inner volume filled with a liquid-gel, said prosthesis adapted to be surgically implanted in a human breast so that the shell retains a desired shape when said inner volume is filled with a liquid-gel said liquid-gel filling said inner volume is cross-linked hyaluronan.
Claim 6
Dependent Claim
73 words
An implantable mammary prosthesis to augment natural breast tissue, said prosthesis having a a hollow shell formed of a medical grade elastomer, said hollow shell having an outer layer and inner volume filled with a liquid-gel, said prosthesis adapted to be surgically implanted in a human breast so that the shell retains a desired shape when said inner volume is filled with a liquid-gel said liquid-gel filling said inner volume is cross-linked hyaluronan.
Claim 7
Independent Claim
90 words
A method of making a surgically implantable mammary prosthesis to augment natural breast tissue, comprising: (a) providing a hollow shell formed of a flexible elastomeric envelope defining an inner volume and said envelope having a means for filling said inner volume, said prosthesis adapted to be surgically implanted in a human breast so that the envelope retains a desired shape when said hollow shell is filled by a liquid-gel substance; and (b) filling said inner volume through said filling means with said liquid-gel wherein said liquid-gel is cross-linked hyaluronic acid.
Claim 8
Independent Claim
90 words
A method of making a surgically implantable mammary prosthesis to augment natural breast tissue, comprising: (a) providing a hollow shell formed of a flexible elastomeric envelope defining an inner volume and said envelope having a means for filling said inner volume, said prosthesis adapted to be surgically implanted in a human breast so that the envelope retains a desired shape when said hollow shell is filled by a liquid-gel substance; and (b) filling said inner volume through said filling means with said liquid-gel wherein said liquid-gel is cross-linked hyaluronic acid.
Claim 9
Dependent Claim
17 words
A method according to claim 5, wherein the hyaluronic acid liquid-gel comprises hyaluronan with aldehyde cross-linking groups.
Claim 10
Dependent Claim
38 words
A method according to claim 5, wherein said cross-linked hyaluronic acid liquid gel is formed by obtaining hyaluronic acid from rooster combs, and treating said hyaluronic acid to have aldehyde cross-linking groups covalently bonded to the hyaluronic acid.
Claim 11
Dependent Claim
20 words
A method according to claim 7, wherein said cross-linked hyaluronic acid is formed from hyaluronic acid reacted with divinyl sulfone.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-06-14 | 1996-12-14 | 1997-06-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-06-14 | 2000-12-14 | 2001-06-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-06-14 | 2004-12-14 | 2005-06-15 | $7700.00 | Window Closed / Lapsed |