Patent US3116410A successfully refreshed from Google Patents.
US5207220A
Expired / Lapsed
US
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Method for administering pharmaceuticals, including liquid surfactant, to the lungs
Assignee: Wellcome Foundation Ltd
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Filing: 1992-03-26
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Granted: 1993-05-04
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Expires: 2012-03-26
Abstract
Abstract A method of administering a liquid pharmaceutical formulation, particularly a surfactant formulation, to at least one lung of a subject in need of such treatment is disclosed. The method is carried out while the subject has a breathing tube extending through the subject's mouth and larynx, and while ventilating at least one lung of the subject through the breathing tube. The method comprises simultaneously administering the liquid pharmaceutical formulation down the breathing tube and into at least one lung of the subject and ventilating at least one lung of the subject through the breathing tube. The method may be performed on premature infants to combat respiratory distress syndrome. A preferred apparatus for carrying out the method of the present invention comprises a breathing tube configured for insertion through a subject's mouth and larynx, a ventilating apparatus operatively associated with the breathing tube, and an injecting device such as a syringe operatively associated with the breathing tube for introducing a liquid pharmaceutical formulation into the breathing tube.
Inventors
- 👤 Walker A. Long
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:38
CPC Classifications
A; A61; A61M; A61M16/00; A61M16/08; A61M16/04; A61M16/0475; A61M16/0477; A61M16/0816; A61M16/0833; A61M16/10; A61M16/14; A61M16/16
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
146 words
A method of administering a liquid stream of surfactant formulation to at least one lung of an infant subject in need of such treatment, the method comprising the steps of: providing a breathing tube extending through the subject's mouth and larynx; ventilating at least one lung of the subject through the breathing tube with an oxygen-rich air steam; providing introducing means formed in a wall of the breathing tube for introducing a liquid stream of surfactant formulation into said breathing tube; delivering said liquid stream such that said liquid stream is in contact with said breathing tube and separate from but in contact with said air stream; and administering the liquid stream of surfactant formulation through the introducing means, down the breathing tube, and into at least one lung of the subject while simultaneously ventilating at least one lung of the subject through the breathing tube.
Claim 2
Independent Claim
146 words
A method of administering a liquid stream of surfactant formulation to at least one lung of an infant subject in need of such treatment, the method comprising the steps of: providing a breathing tube extending through the subject's mouth and larynx; ventilating at least one lung of the subject through the breathing tube with an oxygen-rich air steam; providing introducing means formed in a wall of the breathing tube for introducing a liquid stream of surfactant formulation into said breathing tube; delivering said liquid stream such that said liquid stream is in contact with said breathing tube and separate from but in contact with said air stream; and administering the liquid stream of surfactant formulation through the introducing means, down the breathing tube, and into at least one lung of the subject while simultaneously ventilating at least one lung of the subject through the breathing tube.
Claim 3
Dependent Claim
15 words
A method according to claim 1, wherein the subject is afflicted with respiratory distress syndrome.
Claim 4
Dependent Claim
56 words
A method according to claim 1, further comprising the step of providing injecting means associated with the introducing means for limiting the escape of gas from the breathing tube during administration of the surfactant formulation, and wherein the step of administering the surfactant formulation is carried out by injecting the surfactant formulation into the introducing means.
Claim 5
Dependent Claim
49 words
A method according to claim 1, further comprising the step of positioning a distal end of the breathing tube lower than the introducing means in the breathing tube so that administration of surfactant formulation introduced through the introducing means to the lungs of the subject is assisted by gravity.
Claim 6
Dependent Claim
24 words
A method according to claim 1, further comprising the step of administering a volume of liquid surfactant solution of at least 1 cubic centimeter.
Claim 7
Dependent Claim
30 words
A method according to claim 1, wherein said ventilating step comprises cyclically forcing oxygen-rich air into, and permitting oxygen-depleted air to escape from, at least one lung of the patient.
Claim 8
Dependent Claim
28 words
A method according to claim 2, further comprising the step of conducting said ventilating step at a rate of from about 20 to about 60 breaths per minute.
Claim 9
Independent Claim
184 words
A method of administering a liquid stream of surfactant formulation to at least one lung of an infant subject afflicted with respiratory distress syndrome comprising the steps of: providing a breathing tube extending through the subject's mouth and larynx; ventilating at least one lung of the subject through the breathing tube; providing introducing means formed in the wall of the breathing tube configured for introducing a liquid stream of surfactant formulation into said breathing tube; delivering said liquid stream such that said liquid stream is in contact with said breathing tube and is separate from but in contact with said air stream; administering a volume of said liquid surfactant formulation of at least 1 cubic centimeter through the introducing means, down the breathing tube, and into at least one lung of the subject while simultaneously ventilating at least one lung of the subject through the breathing tube; and wherein said ventilating step comprises cyclically forcing oxygen-rich air into, and permitting oxygen-depleted air to escape from, at least one lung of said subject at a rate of from about 20 to 60 breaths per minute.
Claim 10
Independent Claim
184 words
A method of administering a liquid stream of surfactant formulation to at least one lung of an infant subject afflicted with respiratory distress syndrome comprising the steps of: providing a breathing tube extending through the subject's mouth and larynx; ventilating at least one lung of the subject through the breathing tube; providing introducing means formed in the wall of the breathing tube configured for introducing a liquid stream of surfactant formulation into said breathing tube; delivering said liquid stream such that said liquid stream is in contact with said breathing tube and is separate from but in contact with said air stream; administering a volume of said liquid surfactant formulation of at least 1 cubic centimeter through the introducing means, down the breathing tube, and into at least one lung of the subject while simultaneously ventilating at least one lung of the subject through the breathing tube; and wherein said ventilating step comprises cyclically forcing oxygen-rich air into, and permitting oxygen-depleted air to escape from, at least one lung of said subject at a rate of from about 20 to 60 breaths per minute.
Claim 11
Dependent Claim
146 words
A method according to claim 8, further comprising the steps of: administering said surfactant formulation as a first dose and a second dose; administering said first dose to the subject with the subject laying on the subject's back with the subject's head in the midline position to preferentially administer said formulation on the right lung lower lobe and to the left lung lingula and lower lobe; then turning the subject laterally 45 degrees to the right immediately after said first dose to facilitate delivery of said formulation to the right middle and right upper lobes of the lungs; returning the subject to the midline position; and administering said second dose with the subject positioned in the midline position; and then; turning the subject laterally 45 degrees to the left immediately after said second dose to facilitate delivery of said formulation to the left lung upper lobe.
Claim 12
Dependent Claim
49 words
A method according to claim 8, further comprising the step of providing injecting means associated with the introducing means for limiting the escape of gas from the breathing tube during administration of the surfactant formulation, and administering the surfactant formulation by injecting the surfactant formulation into the introducing means.
Claim 13
Dependent Claim
49 words
A method according to claim 8, further comprising the step of positioning a distal end of the breathing tube lower than the introducing means in the breathing tube so that administration of surfactant formulation introduced through the introducing means to the lungs of the subject is assisted by gravity.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-05-03 | 1996-11-02 | 1997-05-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-05-03 | 2000-11-02 | 2001-05-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-05-03 | 2004-11-02 | 2005-05-04 | $7700.00 | Window Closed / Lapsed |