US5196004A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Infrared laser catheter system
Assignee: Cardiofocus Inc
•
Filing: 1989-10-25
•
Granted: 1993-03-23
•
Expires: 2009-10-25
Abstract
Abstract Laser energy produced by a laser operating in the mid-infrared region (approximately 2 micrometers) is delivered by an optical fiber in a catheter to a surgical site of biological tissue removal and repair. Disclosed laser sources which have an output wavelength in this region include: Holmium-doped Yttrium Aluminum Garnet (Ho:YAG), Holmium-doped Yttrium Lithium Fluoride (Ho:YLF), Holmium-doped Yttrium-Scandium-Gadolinium-Garnet (HO:YSGG), Erbium-doped YAG, Erbium-doped YLF and Thulium-doped YAG. Laser output energy is applied to a silica-based optical fiber which has been specially purified to reduce the hydroxyl-ion concentration to a low level. The catheter may be comprised of a single optical fiber or a plurality of optical fibers arranged to give overlapping output patterns for large area coverage. In a preferred application for the removal of atherosclerotic plaque, a Holmium-doped laser operating in the wavelength range of from about 1.9 to about 2.1 micrometers is preferred. For removal of such plaque by a Holmium-doped laser, it has been found that the threshold energy density should be greater than about 0.6 joules/mm2 per pulse, and that the pulse width should be substantially less than about 83 milliseconds, and that the repetition rate should be in the range of from about 1 to about 10 Hertz.
Inventors
- 👤 Edward L. Sinofsky
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:49
CPC Classifications
A; A61; A61B; A61B18/00; A61B18/18; A61B18/20; A61B18/22; A61B18/24; G; G02; G02B; G02B6/00; G02B6/24; G02B6/42; G02B6/4296; A61B2018/2065; A61B90/00; A61B90/39
Claims Analysis
Total Claims: 50
Claim 1
Independent Claim
122 words
A system for the removal of atherosclerotic plaque comprising: a Holmium-doped laser energy source having a pulsed output in a wavelength range of about 1.9 to about 2.1 micrometers; and an optical fiber for conducting laser energy from a proximal end of said optical fiber to a surgical site at a distal end of said optical fiber to a surgical site at a distal end of said optical fiber, the proximal end of said optical fiber being optically coupled to the output of said laser energy source, said laser energy source providing at least about 0.6 joules per square millimeter per pulse to a surgical site at the distal end of said optical fiber for removal of atherosclerotic plaque substantially by vaporization.
Claim 2
Independent Claim
122 words
A system for the removal of atherosclerotic plaque comprising: a Holmium-doped laser energy source having a pulsed output in a wavelength range of about 1.9 to about 2.1 micrometers; and an optical fiber for conducting laser energy from a proximal end of said optical fiber to a surgical site at a distal end of said optical fiber to a surgical site at a distal end of said optical fiber, the proximal end of said optical fiber being optically coupled to the output of said laser energy source, said laser energy source providing at least about 0.6 joules per square millimeter per pulse to a surgical site at the distal end of said optical fiber for removal of atherosclerotic plaque substantially by vaporization.
Claim 3
Independent Claim
93 words
A system for the removal of atherosclerotic plaque comprising: a laser energy source having a pulsed output and a wavelength range of about 1.4-2.2 micrometers; and an optical fiber for conducting laser energy from a proximal end of said optical fiber to a surgical site at a distal end of said optical fiber, the proximal end of said optical fiber being optically coupled to the output of said laser energy source, said laser energy source providing sufficient energy at the distal end of said optical fiber to remove atherosclerotic plaque substantially by vaporization.
Claim 4
Independent Claim
93 words
A system for the removal of atherosclerotic plaque comprising: a laser energy source having a pulsed output and a wavelength range of about 1.4-2.2 micrometers; and an optical fiber for conducting laser energy from a proximal end of said optical fiber to a surgical site at a distal end of said optical fiber, the proximal end of said optical fiber being optically coupled to the output of said laser energy source, said laser energy source providing sufficient energy at the distal end of said optical fiber to remove atherosclerotic plaque substantially by vaporization.
Claim 5
Independent Claim
131 words
A system for the removal of atherosclerotic plaque comprising: a laser energy source including means for operating said laser energy source in a pulsed mode with an output wavelength in the range of from about 1.4 to about 2.2 micrometers and for operating said laser energy source at an energy sufficient to deliver energy to a surgical site of at least about 9.5×10 -3 joules per square millimeter per pulse for removal of atherosclerotic plaque at the surgical site substantially by vaporization; an optical fiber for conducting laser energy from said laser energy source from a proximal end of said fiber to a surgical site at a distal end of said optical fiber; and means for coupling an output of said laser source to the proximal end of said optical fiber.
Claim 6
Independent Claim
131 words
A system for the removal of atherosclerotic plaque comprising: a laser energy source including means for operating said laser energy source in a pulsed mode with an output wavelength in the range of from about 1.4 to about 2.2 micrometers and for operating said laser energy source at an energy sufficient to deliver energy to a surgical site of at least about 9.5×10 -3 joules per square millimeter per pulse for removal of atherosclerotic plaque at the surgical site substantially by vaporization; an optical fiber for conducting laser energy from said laser energy source from a proximal end of said fiber to a surgical site at a distal end of said optical fiber; and means for coupling an output of said laser source to the proximal end of said optical fiber.
Claim 7
Dependent Claim
31 words
A system as recited in claim 3 wherein said laser energy source comprises a Holmium-doped laser with an output wavelength in the range of from about 1.9 to about 2.1 micrometers.
Claim 8
Dependent Claim
24 words
A system as recited in claim 3 wherein said laser energy source is a Holmium-doped Yttrium-Scandium-Gadolinium-Garnet laser having an output wavelength of 2.088 micrometers.
Claim 9
Dependent Claim
16 words
A system as recited in claim 3 wherein said laser source comprises a Holmium-doped Yttrium-Aluminium-Garnet laser.
Claim 10
Dependent Claim
17 words
A system as recited in claim 3 wherein said laser source comprises a Holmium-doped Yttrium-Lithium Fluoride laser.
Claim 11
Dependent Claim
16 words
A system as recited in claim 3 wherein said laser source comprises an Erbium-doped Yttrium-Lithium-Fluoride laser.
Claim 12
Dependent Claim
16 words
A system as recited in claim 3 wherein said laser source comprises a Thulium-doped Yttrium-Aluminium-Garnet laser.
Claim 13
Dependent Claim
47 words
A system as recited in claim 3 further comprising an aiming laser source generating a visible light output and means for directing said visible light outoput through said laser source and said optical fiber to align said laser and said fiber to visually illuminate said surgical site.
Claim 14
Dependent Claim
120 words
A system as recited in claim 3 wherein said optical fiber further comprises: a plurality of optical fibers having proximal and distal ends; a plurality of partially reflective mirrors arranged in series along an axis of an output beam emitted by said laser source for directing a portion of said output beam of said laser source to said proximal ends of said optical fibers; and a plurality of focusing lenses positioned between said mirrors and said proximal ends of said fibers for focusing portions of said laser output to said proximal ends of said fibers; said fibers being held in a fixed position relative to one another so that optical beams emanating from said distal ends of said fibers overlap.
Claim 15
Dependent Claim
29 words
A system in accordance with claim 3 wherein the surgical site is accessible percutaneously, said system further comprising means for percutaneously placing the distal end of said optical fiber.
Claim 16
Dependent Claim
21 words
A system as recited in claim 3 wherein the pulse width of each pulse is substantially less than about 83 milliseconds.
Claim 17
Dependent Claim
19 words
A system as recited in claim 13 wherein the pulse width is of the order of about 8 milliseconds.
Claim 18
Dependent Claim
66 words
A system as recited in claim 3, wherein said optical fiber comprises a silica further purified to reduce the hydroxyl ion content sufficiently to allow transmission of laser energy from said laser energy source to the surgical site at said wavelength range of about 1.4 to about 2.2 micrometers and at said energy of at least about 9.5 ×10 -3 joules per square millimeter per pulse.
Claim 19
Independent Claim
135 words
A method for the percutaneous removal of atherosclerotic plaque comprising the steps of: percutaneously inserting a catheter containing an optical fiber into the body; guiding a distal end of the optical fiber to a surgical site within the body; operating a laser energy source in a pulsed mode with an output beam having a wavelength in the range of from about 1.4-2.2 micrometers and an energy sufficient to deliver energy to a surgical site of at least about 9.5×10 -3 joules per square millimeter per pulse for removal of atherosclerotic plaque at the surgical site substantially by vaporization; directing the output of the laser energy source to a proximal end of the optical fiber; and directing laser energy propagating down the optical fiber to the surgical site at the distal end of the optical fiber.
Claim 20
Independent Claim
135 words
A method for the percutaneous removal of atherosclerotic plaque comprising the steps of: percutaneously inserting a catheter containing an optical fiber into the body; guiding a distal end of the optical fiber to a surgical site within the body; operating a laser energy source in a pulsed mode with an output beam having a wavelength in the range of from about 1.4-2.2 micrometers and an energy sufficient to deliver energy to a surgical site of at least about 9.5×10 -3 joules per square millimeter per pulse for removal of atherosclerotic plaque at the surgical site substantially by vaporization; directing the output of the laser energy source to a proximal end of the optical fiber; and directing laser energy propagating down the optical fiber to the surgical site at the distal end of the optical fiber.
Claim 21
Dependent Claim
44 words
A method for the percutaneous removal of atherosclerotic plaque in accordance with claim 16 wherein said operating step comprises the step of operating the laser energy source at a repetition rate in the range of from about 1 to about 10 pulses per second.
Claim 22
Dependent Claim
38 words
A method for the percutaneous removal of atherosclerotic plaque in accordance with claim 16 wherein said operating step comprises the step of operating the laser energy source at an output wavelength of about 1.90 to about 2.10 micrometers.
Claim 23
Dependent Claim
37 words
A method for the percutaneous removal of atherosclerotic plaque in accordance with claim 16 wherein said operating step comprises the step of operating the laser energy source with a pulse width substantially less than about 83 milliseconds.
Claim 24
Dependent Claim
69 words
A method for the percutaneous removal of atherosclerotic plaque in accordance with claim 16 further comprising the step of reducing the hydroxyl ion content of the optical fiber sufficiently to allow transmission of laser energy from the laser energy source to the surgical site at said wavelength range of from about 1.4-2.2 micrometers and at said energy of at least about 9.5×10 -3 joules per square millimeter per pulse.
Claim 25
Independent Claim
107 words
A system for the removal of atherosclerotic plaque comprising: a laser energy source having a pulsed output in a wavelength range of about 1.4-2.2 micrometers; and an optical fiber for conducting laser energy from a proximal end of said optical fiber to a surgical site at a distal end of said optical fiber, the proximal end of said optical fiber being optically coupled to the output of said laser energy source, said laser energy source providing at least about 9.5×10 -3 joules per square millimeter per pulse to a surgical site at the distal end of said optical fiber for removal of atherosclerotic plaque substantially by vaporization.
Claim 26
Independent Claim
107 words
A system for the removal of atherosclerotic plaque comprising: a laser energy source having a pulsed output in a wavelength range of about 1.4-2.2 micrometers; and an optical fiber for conducting laser energy from a proximal end of said optical fiber to a surgical site at a distal end of said optical fiber, the proximal end of said optical fiber being optically coupled to the output of said laser energy source, said laser energy source providing at least about 9.5×10 -3 joules per square millimeter per pulse to a surgical site at the distal end of said optical fiber for removal of atherosclerotic plaque substantially by vaporization.
Claim 27
Independent Claim
108 words
A system for the removal of atherosclerotic plaque comprising: an Erbium-doped YAG laser energy source having a pulsed output at a wavelength of about 1.55 micrometers; and an optical fiber for conducting laser energy from a proximal end of said optical fiber to a surgical site at a distal end of said optical fiber, the proximal end of said optical fiber being optically coupled to the output of said laser energy source, said laser energy source providing at least about 9.5×10 -3 joules per square millimeter per pulse to a surgical site at the distal end of said optical fiber for removal of atherosclerotic plaque substantially by vaporization.
Claim 28
Independent Claim
108 words
A system for the removal of atherosclerotic plaque comprising: an Erbium-doped YAG laser energy source having a pulsed output at a wavelength of about 1.55 micrometers; and an optical fiber for conducting laser energy from a proximal end of said optical fiber to a surgical site at a distal end of said optical fiber, the proximal end of said optical fiber being optically coupled to the output of said laser energy source, said laser energy source providing at least about 9.5×10 -3 joules per square millimeter per pulse to a surgical site at the distal end of said optical fiber for removal of atherosclerotic plaque substantially by vaporization.
Claim 29
Independent Claim
107 words
A system for the removal of atherosclerotic plaque comprising: an Erbium-doped YLF laser energy source having a pulsed output at a wavelength of about 1.73 micrometers; and an optical fiber for conducting laser energy from a proximal end of said optical fiber to a surgical site at a distal end of said optical fiber, the proximal end of said optical fiber being optically coupled to the output of said laser energy source, said laser energy source providing at least about 5.7 joules per square millimeter per pulse to a surgical site at the distal end of said optical fiber for removal of atherosclerotic plaque substantially by vaporization.
Claim 30
Independent Claim
107 words
A system for the removal of atherosclerotic plaque comprising: an Erbium-doped YLF laser energy source having a pulsed output at a wavelength of about 1.73 micrometers; and an optical fiber for conducting laser energy from a proximal end of said optical fiber to a surgical site at a distal end of said optical fiber, the proximal end of said optical fiber being optically coupled to the output of said laser energy source, said laser energy source providing at least about 5.7 joules per square millimeter per pulse to a surgical site at the distal end of said optical fiber for removal of atherosclerotic plaque substantially by vaporization.
Claim 31
Independent Claim
107 words
A system for the removal of atherosclerotic plaque comprising: a Thulium-doped YAG laser energy source having a pulsed output at a wavelength of about 1.88 micrometers; and an optical fiber for conducting laser energy from a proximal end of said optical fiber to a surgical site at a distal end of said optical fiber, the proximal end of said optical fiber being optically coupled to the output of said laser energy source, said laser energy source providing at least about 0.76 joules per square millimeter per pulse to a surgical site at the distal end of said optical fiber for removal of atherosclerotic plaque substantially by vaporization.
Claim 32
Independent Claim
107 words
A system for the removal of atherosclerotic plaque comprising: a Thulium-doped YAG laser energy source having a pulsed output at a wavelength of about 1.88 micrometers; and an optical fiber for conducting laser energy from a proximal end of said optical fiber to a surgical site at a distal end of said optical fiber, the proximal end of said optical fiber being optically coupled to the output of said laser energy source, said laser energy source providing at least about 0.76 joules per square millimeter per pulse to a surgical site at the distal end of said optical fiber for removal of atherosclerotic plaque substantially by vaporization.
Claim 33
Independent Claim
158 words
A system for the removal of atherosclerotic plaque comprising: a Holmium-doped laser energy source including means for operating said laser energy source in a pulsed mode with an output wavelength in the range of from about 1.90 to about 2.1 micrometers, for operating said laser energy source at an energy sufficient to deliver energy to a surgical site of at least about 0.6 joules per square millimeter per pulse, for operating said laser energy source with a pulse width substantially less than about 83 milliseconds and for operating said laser energy source at a repetition rate in the range of from about 1 to about 10 pulses per second; an optical fiber for conducting laser energy from said laser energy source from a proximal end of said fiber to a surgical site at a distal end of said optical fiber; and means for directing an output of said laser source to a proximal end of said optical fiber.
Claim 34
Independent Claim
158 words
A system for the removal of atherosclerotic plaque comprising: a Holmium-doped laser energy source including means for operating said laser energy source in a pulsed mode with an output wavelength in the range of from about 1.90 to about 2.1 micrometers, for operating said laser energy source at an energy sufficient to deliver energy to a surgical site of at least about 0.6 joules per square millimeter per pulse, for operating said laser energy source with a pulse width substantially less than about 83 milliseconds and for operating said laser energy source at a repetition rate in the range of from about 1 to about 10 pulses per second; an optical fiber for conducting laser energy from said laser energy source from a proximal end of said fiber to a surgical site at a distal end of said optical fiber; and means for directing an output of said laser source to a proximal end of said optical fiber.
Claim 35
Dependent Claim
29 words
A system in accordance with claim 25 wherein the surgical site is accessible percutaneously, said system further comprising means for percutaneously placing the distal end of said optical fiber.
Claim 36
Independent Claim
153 words
A system for the removal of atherosclerotic plaque comprising: an Erbium-doped YAG laser energy source including means for operating said laser energy source in a pulsed mode with an output wavelength of about 1.55 micrometers, for operating said laser energy source at an energy sufficient to deliver energy to a surgical site of at least about 9.5×10 -3 joules per square millimeter per pulse, for operating said laser energy source with a pulse width substantially less than about 83 milliseconds and for operating said laser energy source at a repetition rate in the range of from about 1 to about 10 pulses per second; an optical fiber for conducting laser energy from said laser energy source from a proximal end of said fiber to a surgical site at a distal end of said optical fiber; and means for directing an output of said laser source to a proximal end of said optical fiber.
Claim 37
Independent Claim
153 words
A system for the removal of atherosclerotic plaque comprising: an Erbium-doped YAG laser energy source including means for operating said laser energy source in a pulsed mode with an output wavelength of about 1.55 micrometers, for operating said laser energy source at an energy sufficient to deliver energy to a surgical site of at least about 9.5×10 -3 joules per square millimeter per pulse, for operating said laser energy source with a pulse width substantially less than about 83 milliseconds and for operating said laser energy source at a repetition rate in the range of from about 1 to about 10 pulses per second; an optical fiber for conducting laser energy from said laser energy source from a proximal end of said fiber to a surgical site at a distal end of said optical fiber; and means for directing an output of said laser source to a proximal end of said optical fiber.
Claim 38
Dependent Claim
29 words
A system in accordance with claim 27 wherein the surgical site is accessible percutaneously, said system further comprising means for percutaneously placing the distal end of said optical fiber.
Claim 39
Independent Claim
152 words
A system for the removal of atherosclerotic plaque comprising: an Erbium-doped YLF laser energy source including means for operating said laser energy source in a pulsed mode with an output wavelength of about 1.73 micrometers, for operating said laser energy source at an energy sufficient to deliver energy to a surgical site of at least about 5.7 joules per square millimeter per pulse, for operating said laser energy source with a pulse width substantially less than about 83 milliseconds and for operating said laser energy source at a repetition rate in the range of from about 1 to about 10 pulses per second; an optical fiber for conducting laser energy from said laser energy source from a proximal end of said fiber to a surgical site at a distal end of said optical fiber; and means for directing an output of said laser source to a proximal end of said optical fiber.
Claim 40
Independent Claim
152 words
A system for the removal of atherosclerotic plaque comprising: an Erbium-doped YLF laser energy source including means for operating said laser energy source in a pulsed mode with an output wavelength of about 1.73 micrometers, for operating said laser energy source at an energy sufficient to deliver energy to a surgical site of at least about 5.7 joules per square millimeter per pulse, for operating said laser energy source with a pulse width substantially less than about 83 milliseconds and for operating said laser energy source at a repetition rate in the range of from about 1 to about 10 pulses per second; an optical fiber for conducting laser energy from said laser energy source from a proximal end of said fiber to a surgical site at a distal end of said optical fiber; and means for directing an output of said laser source to a proximal end of said optical fiber.
Claim 41
Dependent Claim
29 words
A system in accordance with claim 29 wherein the surgical site is accessible percutaneously, said system further comprising means for percutaneously placing the distal end of said optical fiber.
Claim 42
Independent Claim
152 words
A system for the removal of atherosclerotic plaque comprising: a Thulium-doped YAG laser energy source including means for operating said laser energy source in a pulsed mode with an output wavelength of about 1.88 micrometers, for operating said laser energy source at an energy sufficient to deliver energy to a surgical site of at least about 0.76 joules per square millimeter per pulse, for operating said laser energy source with a pulse width substantially less than about 83 milliseconds and for operating said laser energy source at a repetition rate in a range of from about 1 to about 10 pulses per second; an optical fiber for conducting laser energy from said laser energy source from a proximal end of said fiber to a surgical site at a distal end of said optical fiber; and means for directing an output of said laser source to a proximal end of said optical fiber.
Claim 43
Independent Claim
152 words
A system for the removal of atherosclerotic plaque comprising: a Thulium-doped YAG laser energy source including means for operating said laser energy source in a pulsed mode with an output wavelength of about 1.88 micrometers, for operating said laser energy source at an energy sufficient to deliver energy to a surgical site of at least about 0.76 joules per square millimeter per pulse, for operating said laser energy source with a pulse width substantially less than about 83 milliseconds and for operating said laser energy source at a repetition rate in a range of from about 1 to about 10 pulses per second; an optical fiber for conducting laser energy from said laser energy source from a proximal end of said fiber to a surgical site at a distal end of said optical fiber; and means for directing an output of said laser source to a proximal end of said optical fiber.
Claim 44
Dependent Claim
29 words
A system in accordance with claim 31 wherein the surgical site is accessible percutaneously, said system further comprising means for percutaneously placing the distal end of said optical fiber.
Claim 45
Independent Claim
153 words
A method for the percutaneous removal of atherosclerotic plaque comprising the steps of: percutaneously inserting a catheter containing an optical fiber into the body; guiding a distal end of the optical fiber to a surgical site within the body; operating a laser energy source in a pulsed mode with an output beam having a wavelength of about 1.55 micrometers and an energy sufficient to deliver energy to a surgical site of at least about 9.5×10 -3 joules per square millimeter per pulse, said laser energy source being operated with a pulse width substantially less than about 83 milliseconds and at a repetition rate in the range of from about 1 to about 10 pulses per second; directing the output of the laser energy source to a proximal end of the optical fiber; and directing laser energy propagating down the optical fiber to the surgical site at the distal end of the optical fiber.
Claim 46
Independent Claim
153 words
A method for the percutaneous removal of atherosclerotic plaque comprising the steps of: percutaneously inserting a catheter containing an optical fiber into the body; guiding a distal end of the optical fiber to a surgical site within the body; operating a laser energy source in a pulsed mode with an output beam having a wavelength of about 1.55 micrometers and an energy sufficient to deliver energy to a surgical site of at least about 9.5×10 -3 joules per square millimeter per pulse, said laser energy source being operated with a pulse width substantially less than about 83 milliseconds and at a repetition rate in the range of from about 1 to about 10 pulses per second; directing the output of the laser energy source to a proximal end of the optical fiber; and directing laser energy propagating down the optical fiber to the surgical site at the distal end of the optical fiber.
Claim 47
Independent Claim
151 words
A method for the percutaneous removal of atherosclerotic plaque comprising the steps of: percutaneously inserting a catheter containing an optical fiber into the body; guiding a distal end of the optical fiber to a surgical site within the body; operating a laser energy source in a pulsed mode with an output beam having a wavelength of about 1.73 micrometers and an energy sufficient to deliver energy to a surgical site of at least about 5.7 joules per square millimeter per pulse, said energy source being operated with a pulse width substantially less than about 83 milliseconds and at a repetition rate in the range of from about 1 to about 10 pulses per second; directing the output of the laser energy source to a proximal end of the optical fiber; and directing laser energy propagating down the optical fiber to the surgical site at the distal end of the optical fiber.
Claim 48
Independent Claim
151 words
A method for the percutaneous removal of atherosclerotic plaque comprising the steps of: percutaneously inserting a catheter containing an optical fiber into the body; guiding a distal end of the optical fiber to a surgical site within the body; operating a laser energy source in a pulsed mode with an output beam having a wavelength of about 1.73 micrometers and an energy sufficient to deliver energy to a surgical site of at least about 5.7 joules per square millimeter per pulse, said energy source being operated with a pulse width substantially less than about 83 milliseconds and at a repetition rate in the range of from about 1 to about 10 pulses per second; directing the output of the laser energy source to a proximal end of the optical fiber; and directing laser energy propagating down the optical fiber to the surgical site at the distal end of the optical fiber.
Claim 49
Independent Claim
152 words
A method for the percutaneous removal of atherosclerotic plaque comprising the steps of: percutaneously inserting a catheter containing an optical fiber into the body; guiding a distal end of the optical fiber to a surgical site within the body; operating a laser energy source in a pulsed mode with an output beam having a wavelength of about 1.88 micrometers and an energy sufficient to deliver energy to a surgical site of at least about 0.76 joules per square millimeter per pulse, said laser energy source being operated with a pulse width substantially less than about 83 milliseconds and at a repetition rate in the range of from about 1 to about 10 pulses per second; directing the output of the laser energy source to a proximal end of the optical fiber; and directing laser energy propagating down the optical fiber to the surgical site at the distal end of the optical fiber.
Claim 50
Independent Claim
152 words
A method for the percutaneous removal of atherosclerotic plaque comprising the steps of: percutaneously inserting a catheter containing an optical fiber into the body; guiding a distal end of the optical fiber to a surgical site within the body; operating a laser energy source in a pulsed mode with an output beam having a wavelength of about 1.88 micrometers and an energy sufficient to deliver energy to a surgical site of at least about 0.76 joules per square millimeter per pulse, said laser energy source being operated with a pulse width substantially less than about 83 milliseconds and at a repetition rate in the range of from about 1 to about 10 pulses per second; directing the output of the laser energy source to a proximal end of the optical fiber; and directing laser energy propagating down the optical fiber to the surgical site at the distal end of the optical fiber.
References Cited (Backward Citations)
US1751584A
Cited
US3327712A
Cited
US3884236A
Cited
US3769963A
Cited
US4233493A
Cited
US3947780A
Cited
US3983511A
Cited
US4146019A
Cited
US4110702A
Cited
US4141362A
Cited
US4170997A
Cited
US4207874A
Cited
US4309998A
Cited
US4266548A
Cited
US4469098A
Cited
US4350150A
Cited
US4383729A
Cited
US4330763A
Cited
US4321559A
Cited
US4353893A
Cited
US4425503A
Cited
US4386428A
Cited
US4445418A
Cited
US4458683A
Cited
US4418688A
Cited
US4454882A
Cited
WO1983001311A1
Cited
US4800876B1
Cited
US4848336A
Cited
US4800876A
Cited
US4470407A
Cited
US4515612A
Cited
US4556057A
Cited
US4566765A
Cited
US4784135A
Cited
US4566453A
Cited
US4576177A
Cited
US4784132A
Cited
US4784132B1
Cited
US4503854A
Cited
US4504297A
Cited
US4672969A
Cited
US4572189A
Cited
US4686979A
Cited
US4559942A
Cited
US4685458A
Cited
US4538608A
Cited
US4732448A
Cited
US4641912A
Cited
US4817601A
Cited
US4648892A
Cited
US4850351A
Cited
US4950266A
Cited
US4917084A
Cited
US4750486A
Cited
US4654024A
Cited
US4799754A
Cited
US4775361A
Cited
US4819632A
Cited
US4830460A
Cited
US4905689A
Cited
US4854315A
Cited
US4878492A
Cited
US4852567A
Cited
US4929246A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-03-22 | 1996-09-21 | 1997-03-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-03-22 | 2000-09-21 | 2001-03-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-03-22 | 2004-09-21 | 2005-03-23 | $7700.00 | Window Closed / Lapsed |