US5194266A
Expired / Lapsed
US
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Amphotericin B/cholesterol sulfate composition and method
Assignee: LIPSOME TECHNOLOGY Inc
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Filing: 1991-12-19
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Granted: 1993-03-16
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Expires: 2011-12-19
Abstract
Abstract An amphotericin B composition containing particles of amphotericin B and cholesterol sulfate, in a molar ratio of between about 1:1 to 2:1. The particles, when stored in lyophilized form and reconstituted in an aqueous suspension, have particle sizes predominantly between about 50-250 nm. The composition has stable particle sizes in an aqueous suspension over a several-day storage period. The composition is significantly less toxic and more effective in treating fungal infection than prior amphotericin B formulations.
Inventors
- 👤 Robert Abra
- 👤 Luke S. S. Guo
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 02:13
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/107; A61K9/1075; A61K9/14; A61K9/19
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
28 words
An amphotericin B composition comprising particles of amphotericin B containing cholesterol sulfate in a mole ratio of amphotericin B to cholesterol sulfate of between about 1:1 to 2:1.
Claim 2
Dependent Claim
28 words
An amphotericin B composition comprising particles of amphotericin B containing cholesterol sulfate in a mole ratio of amphotericin B to cholesterol sulfate of between about 1:1 to 2:1.
Claim 3
Dependent Claim
23 words
The composition of claim 1, wherein the particles are suspended in an aqueous medium, and have particle sizes predominantly between about 50-250 nm.
Claim 4
Dependent Claim
55 words
The composition of claim 2, which is produced by the steps of: (a) dispersing an aqueous suspension of amphotericin B and cholesterol sulfate, in a molar ratio of between 1:1 to 2:1 to optical clarity, (b) lyophilizing the suspension in the presence of a cryoprotectant, and (c) reconstituting the lyophilized material with an aqueous medium.
Claim 5
Dependent Claim
20 words
The composition of claim 1, wherein the molar ratio of amphotericin B to cholesterol sulfate is about 1.5:1 to 2:1.
References Cited (Backward Citations)
US4822777A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-03-15 | 1996-09-14 | 1997-03-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-03-15 | 2000-09-14 | 2001-03-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-03-15 | 2004-09-14 | 2005-03-16 | $7700.00 | Window Closed / Lapsed |