US5183045A
Expired / Lapsed
US
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Nmr measuring method and measuring apparatus for tissue of a living body
Assignee: Otsuka Electronics Co Ltd
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Filing: 1989-06-12
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Granted: 1993-02-02
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Expires: 2009-06-12
Abstract
Abstract There is carried out an NMR measurement in which a receiver coil (7) for receiving an NMR free induction signal comes in contact with or in close vicinity to one side of tissue of a living body (1) immersed in a perfusion solution (4), while a portion or whole body of the receiver coil (7) is so held as not to come in contact with the perfusion solution (4). According to this measuring method, since a portion or whole body of the receiver coil (7) does not come in contact with the perfusion solution (4), the receiver coil (7) is hardly subject to the electromagnetic influence of changes in the perfusion solution (4). This prevents the free induction signal from being embedded in noise, assuring measurement with high sensitivity. Even for a large-size internal organ, only a signal from an area presenting a uniform magnetic field may be acquired, since the measurement is carried out with the receiver coil (7) coming in contact with or in close vicinity to one side of the internal organ. Thus, a high-resolution free induction signal may be acquired.
Inventors
- 👤 Susumu Takamura
- 👤 Takashi Nakamura
- 👤 Makoto Okawauchi
- 👤 Harumi Toda
- 👤 Ichiro Kanki
- 👤 Minoru Yoshida
- 👤 Toshiyuki Imoto
- 👤 Naomi Negayama
- 👤 Koichi Oka
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:53
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/28; G01R33/30; A; A61; A61B; A61B5/00; A61B5/05; A61B5/055; G01R33/32; G01R33/34; G01R33/34007; G01R33/34046; G01R33/34053; G01R33/341; G01R33/44; G01R33/46; G01R33/465; Y; Y10; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
72 words
An NMR measuring method for tissue of a living body immersed in a perfusion solution comprising (1) immersing the tissue of the living body in the perfusion solution, (2) placing a receiver coil for receiving an NMR free induction signal in contact with or in close vicinity to only one side of the tissue, (3) holding the receiver coil to prevent contact with the perfusion solution, and (4) obtaining an NMR measurement.
Claim 2
Dependent Claim
72 words
An NMR measuring method for tissue of a living body immersed in a perfusion solution comprising (1) immersing the tissue of the living body in the perfusion solution, (2) placing a receiver coil for receiving an NMR free induction signal in contact with or in close vicinity to only one side of the tissue, (3) holding the receiver coil to prevent contact with the perfusion solution, and (4) obtaining an NMR measurement.
Claim 3
Dependent Claim
81 words
An NMR measuring method for tissue of a living body immersed in a perfusion solution comprising (1) immersing the tissue of the living body in the perfusion solution, (2) placing a receiver coil for receiving an NMR free induction signal in contact with or in close vicinity to only one side of the tissue, (3) holding the receiver coil so that only a part of the receiver coil comes in contact with the perfusion solution, and (4) obtaining an NMR measuring.
Claim 4
Dependent Claim
81 words
An NMR measuring method for tissue of a living body immersed in a perfusion solution comprising (1) immersing the tissue of the living body in the perfusion solution, (2) placing a receiver coil for receiving an NMR free induction signal in contact with or in close vicinity to only one side of the tissue, (3) holding the receiver coil so that only a part of the receiver coil comes in contact with the perfusion solution, and (4) obtaining an NMR measuring.
Claim 5
Dependent Claim
123 words
An NMR measuring apparatus for tissue of a living body immersed in a perfusion solution comprising a perfusion cell which receives a perfusion solution, a means for generating an NMR free induction signal, a receiver coil for receiving the NMR free induction signal connection to said means for generating an NMR free induction signal. a material, which does not exert a negative influence upon a transmission of the free induction signal, partially or completely surrounding the receiver coil, a measuring device coupled to the receiver coil, wherein the receiver coil does not come into contact with the perfusion solution, and the receiver coil is placed in contact with or in close vicinity to only one side of the tissue of the living body.
Claim 6
Dependent Claim
123 words
An NMR measuring apparatus for tissue of a living body immersed in a perfusion solution comprising a perfusion cell which receives a perfusion solution, a means for generating an NMR free induction signal, a receiver coil for receiving the NMR free induction signal connection to said means for generating an NMR free induction signal. a material, which does not exert a negative influence upon a transmission of the free induction signal, partially or completely surrounding the receiver coil, a measuring device coupled to the receiver coil, wherein the receiver coil does not come into contact with the perfusion solution, and the receiver coil is placed in contact with or in close vicinity to only one side of the tissue of the living body.
Claim 7
Dependent Claim
28 words
An NMR measuring apparatus for tissue of a living body as set forth in claim 3, wherein the material forms a container which completely surrounds the receiver coil.
Claim 8
Dependent Claim
28 words
An NMR measuring apparatus for tissue of a living body as set forth in claim 3, wherein the material forms a container which partially surrounds the receiver coil.
Claim 9
Dependent Claim
28 words
An NMR measuring apparatus for tissue of a living body as set forth in claim 3, wherein the inside of the receiver coil is filled with a resin.
Claim 10
Dependent Claim
40 words
An NMR measuring apparatus for tissue of a living body as set forth in claim 3, wherein the material is a container made of a resin selected from the group consisting of Juracon resin, polytetrafluorinated ethylene resin, and acrylic resin.
Claim 11
Dependent Claim
22 words
An NMR measuring apparatus for tissue of a living body as set forth in claim 3, wherein the material is a resin.
Claim 12
Dependent Claim
25 words
An NMR measuring apparatus for tissue of a living body as set forth in claim 3, wherein the receiver coil is molded with a resin.
Claim 13
Dependent Claim
33 words
An NMR measuring apparatus for tissue of a living body as set forth in claim 3, wherein the perfusion solution is selected from the group consisting of phosphoric acid and physiological saline solution.
Claim 14
Dependent Claim
103 words
An NMR measuring method for tissue of a living body immersed in a perfusion solution or by a flowing perfusion solution comprising: (1) immersing the tissue of the living body in the perfusion solution or by the flowing perfusion solution and changing the concentration of the perfusion solution or the flowing perfusion solution over time, (2) placing a receiver coil for receiving an NMR free induction signal in contact with or in close vicinity to only one side of the tissue, (3) holding the receiver coil to prevent contact with the perfusion solution or the flowing perfusion, and (4) obtaining an NMR measurement.
Claim 15
Dependent Claim
103 words
An NMR measuring method for tissue of a living body immersed in a perfusion solution or by a flowing perfusion solution comprising: (1) immersing the tissue of the living body in the perfusion solution or by the flowing perfusion solution and changing the concentration of the perfusion solution or the flowing perfusion solution over time, (2) placing a receiver coil for receiving an NMR free induction signal in contact with or in close vicinity to only one side of the tissue, (3) holding the receiver coil to prevent contact with the perfusion solution or the flowing perfusion, and (4) obtaining an NMR measurement.
Claim 16
Dependent Claim
113 words
An NMR measuring method for tissue of a living body immersed in a perfusion solution or by a flowing perfusion solution comprising: (1) immersing the tissue of the living body in the perfusion solution or by the flowing perfusion solution and changing the concentration of the perfusion solution or the flowing perfusion solution over time; (2) placing a receiver coil for receiving an NMR free induction signal in contact with or in close vicinity to only one side of the tissue, (3) holding the receiver coil so that only a part of the receiver coil comes in contact with the perfusion solution or the flowing perfusion solution, and (4) obtaining an NMR measurement.
Claim 17
Dependent Claim
113 words
An NMR measuring method for tissue of a living body immersed in a perfusion solution or by a flowing perfusion solution comprising: (1) immersing the tissue of the living body in the perfusion solution or by the flowing perfusion solution and changing the concentration of the perfusion solution or the flowing perfusion solution over time; (2) placing a receiver coil for receiving an NMR free induction signal in contact with or in close vicinity to only one side of the tissue, (3) holding the receiver coil so that only a part of the receiver coil comes in contact with the perfusion solution or the flowing perfusion solution, and (4) obtaining an NMR measurement.
References Cited (Backward Citations)
US4291271A
Cited
US4409550A
Cited
US4413233A
Cited
US4607226A
Cited
US4642569A
Cited
US4639364A
Cited
US5072732A
Cited
US4775836A
Cited
US4998065A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-02-02 | 1996-08-03 | 1997-02-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-02-02 | 2000-08-03 | 2001-02-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-02-02 | 2004-08-03 | 2005-02-02 | $7700.00 | Window Closed / Lapsed |