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US5171661A
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Medium for lyophilization of erythrocytes
Assignee: Terumo BCT Inc
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Filing: 1990-07-31
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Granted: 1992-12-15
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Expires: 2010-07-31
Abstract
Abstract A process and medium are disclosed for the lyophilization of red blood cells which comprises the use of solutions including monosaccharide hexoses and pentoses, and/or biocompatible polymers to permit the reconstitution of viable red blood cells.
Inventors
- 👤 Raymond P. Goodrich, Jr.
- 👤 Christine M. Williams
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:43
CPC Classifications
A; A61; A61K; A61K35/00; A61K35/12; A61K35/14; A61K35/18
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
60 words
A medium for the lyophilization of erythrocytes, comprising a lyophilizing buffer solution which includes: a monosaccharide which is present in the solution in a concentration of from about 0.5 molar up to about 4 molar, and a polymer having a molecular weight of from about 10K to about 360K which is present in a concentration of at least 0.1 millimolar.
Claim 2
Independent Claim
60 words
A medium for the lyophilization of erythrocytes, comprising a lyophilizing buffer solution which includes: a monosaccharide which is present in the solution in a concentration of from about 0.5 molar up to about 4 molar, and a polymer having a molecular weight of from about 10K to about 360K which is present in a concentration of at least 0.1 millimolar.
Claim 3
Dependent Claim
18 words
The medium of claim 1 wherein the monosaccharide is selected from the group consisting of pentoses and hexoses.
Claim 4
Dependent Claim
21 words
The medium of claim 1 wherein the monosaccharide is selected from the group consisting of xylose, glucose, ribose, mannose and fructose.
Claim 5
Dependent Claim
18 words
The medium of claim 1 wherein the polymer is selected from the group consisting of polyvinylpyrrolidone, and dextran.
Claim 6
Dependent Claim
18 words
The medium of claim 2 wherein the polymer is selected from the group consisting of polyvinylpyrrolidone and dextran.
Claim 7
Dependent Claim
18 words
The medium of claim 3 wherein the polymer is selected from the group consisting of polyvinylpyrrolidone and dextran.
Claim 8
Dependent Claim
10 words
The medium of claim 1 wherein the polymer is polyvinylpyrrolidone.
Claim 9
Dependent Claim
10 words
The medium of claim 2 wherein the polymer is polyvinylpyrrolidone.
Claim 10
Dependent Claim
10 words
The medium of claim 3 wherein the polymer is polyvinylpyrrolidone.
References Cited (Backward Citations)
DE2039182A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-12-15 | 1996-06-15 | 1996-12-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-12-15 | 2000-06-15 | 2000-12-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-12-15 | 2004-06-15 | 2004-12-15 | $7700.00 | Window Closed / Lapsed |