US5157111A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of bonding collagen to fibers, particularly dacron
Assignee: ABS Lifesciences Inc
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Filing: 1991-05-02
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Granted: 1992-10-20
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Expires: 2011-05-02
Abstract
Abstract A method of bonding collagen to synthetic polyester fibers, particularly DACRON. The method involves providing synthetic polyester fabric fibers having repeating carbonyl groups, hydrogenating the repeating carbonyl groups and then conducting a transesterification step which includes the addition of free amine groups. The free amine groups are reacted with a bifunctional crosslinking agent to produce modified polyester fibers. The final step involves adding collagen to the modified polyester fibers for a time sufficient to produce covalent bonding of the collagen to the fibers. The invention also involves the making of a fabric matrix comprised of synthetic polyester fibers, particularly DACRON, and collagen being covalently bound to the fibers. Such matrix can be utilized in ligament prosthesis design.
Inventors
- 👤 James M. Pachence
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 07:37
CPC Classifications
D; D06; D06M; D06M15/00; D06M15/01; D06M15/15; A; A61; A61L; A61L27/00; A61L27/28; A61L27/34; C; C07; C07K; C07K14/00; C07K14/435; C07K14/78; Y; Y10; Y10S; Y10S128/00; Y10S128/08; Y10T; Y10T428/00; Y10T428/29; Y10T428/2913; Y10T428/2929
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
71 words
A method of covalent bonding collagen to DACRON fibers, said method comprising providing DACRON fibers having repeating carbonyl groups, hydrogenating said repeating carbonyl groups, conducting a transesterification step which includes the addition of free amine groups, reacting the free amine groups with a bifunctional crosslinking agent to produce modified DACRON and adding collagen to said modified DACRON fibers for a time sufficient to produce covalent bonding of collagen of said fibers.
Claim 2
Independent Claim
71 words
A method of covalent bonding collagen to DACRON fibers, said method comprising providing DACRON fibers having repeating carbonyl groups, hydrogenating said repeating carbonyl groups, conducting a transesterification step which includes the addition of free amine groups, reacting the free amine groups with a bifunctional crosslinking agent to produce modified DACRON and adding collagen to said modified DACRON fibers for a time sufficient to produce covalent bonding of collagen of said fibers.
Claim 3
Dependent Claim
27 words
The method of claim 1 wherein said hydrogenating is accomplished by a reduction of the carbonyl groups in said DACRON, utilizing sodium borohydride as the reduction agent.
Claim 4
Dependent Claim
30 words
The method of claim 1 wherein said transesterification step is carried out with phenyl carbamate and wherein the free amines added in the transesterification step are reacted with dimethyl suberimidate.
Claim 5
Dependent Claim
21 words
The method of claim 1 wherein said collagen is selected from the group consisting of chicken collagen and bovine tendon collagen.
Claim 6
Dependent Claim
44 words
The method of claim 4 wherein said chicken collagen is provided in an aqueous dispersion at a concentration of 1% by weight, at a pH 9, 10 mM NaH CO 3 buffer and wherein said dispersion is reacted with said DACRON for 24 hours.
Claim 7
Dependent Claim
50 words
The method of claim 4 wherein said bovine tendon collagen is provided in a dispersion at a concentration of 1% by weight, at a pH of 3.5 which is rapidly increased to pH 9 with 1M NaOH to precipitate collagen which is then reacted with said DACRON for 24 hours.
Claim 8
Dependent Claim
22 words
A fabric matrix comprised of fibers and collagen being covalently bound to said fibers in accordance with the method of claim 1.
Claim 9
Dependent Claim
11 words
The fabric matrix of claim 7 utilized in ligament prosthesis design.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-10-20 | 1996-04-20 | 1996-10-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-10-20 | 2000-04-20 | 2000-10-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-10-20 | 2004-04-20 | 2004-10-20 | $7700.00 | Window Closed / Lapsed |