US5156844A
Expired / Lapsed
US
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Neurological therapy system
Assignee: Brown University Research Foundation Inc
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Filing: 1992-02-26
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Granted: 1992-10-20
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Expires: 2012-02-26
Abstract
Abstract Neurological therapy devices are disclosed for the local and controlled delivery of a neurotransmitter to the brain of a subject suffering from neurotransmitter deficiency or dysfunction. In one embodiment the device includes a biocompatible, implantable, and retrievable polymeric insert including a source of neurotransmitter embedded therein. In another embodiment, the device includes a retrievable source of neurotransmitter including at least one neurotransmitter-secreting cell encapsulated within a semipermeable membrane allowing the diffusion therethrough of the neurotransmitter, and further includes a source of growth factor in close proximity to the neurotransmitter-secreting cells.
Inventors
- 👤 Patrick Aebischer
- 👤 Shelley R. Winn
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:59
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0087; A61K9/0092; A61F; A61F2/00; A61F2/02; A61F2/022; A61K35/00; A61K35/12; A61K9/0012; A61K9/0019; A61K9/0024; A61K9/0085; A61M; A61M31/00; A61M31/002; B; B01; B01J; B01J13/00; B01J13/02; C; C12; C12N; C12N11/00; C12N11/02; C12N11/04; C12N5/00; C12N5/0012; C12N5/06; C12N5/0602; C12N5/0613; C12N5/0614; C12N5/0618; C12N5/0619; C12N5/0676; A61K2035/126; A61M2210/00; A61M2210/06; A61M2210/0687; A61M2210/0693; C12N2533/00; C12N2533/30
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
53 words
A neurological therapy device for the local and controlled delivery of a neurotransmitter to the brain of a subject, said device comprising a biocompatible, implanatble, and retrievable solid polymeric insert including a noncellular source of a neurotransmitter embedded within said insert for controlled linear release of said neurotransmitter from said insert by leaching.
Claim 2
Dependent Claim
53 words
A neurological therapy device for the local and controlled delivery of a neurotransmitter to the brain of a subject, said device comprising a biocompatible, implanatble, and retrievable solid polymeric insert including a noncellular source of a neurotransmitter embedded within said insert for controlled linear release of said neurotransmitter from said insert by leaching.
Claim 3
Dependent Claim
35 words
The system of claim 1 wherein said neurotransmitter is selected from the group consisting of gamma aminobutyric acid, serotonin, acetylcholine, norepinephrine, endorphins, enkephalins, dopamine, and precursors, agonists, active analogs, and active fragments of said neurotransmitter.
Claim 4
Dependent Claim
13 words
The system of claim 2 wherein said neurotransmitter is the dopamine precursor L-dopa.
Claim 5
Dependent Claim
13 words
The system of claim 2 wherein said neurotransmitter is the dopamine against bromocriptine.
Claim 6
Dependent Claim
25 words
The device of claim 1 wherein said polymeric insert includes pores having a molecular weight exclusion range from about 1 kD to about 1,000 kD.
Claim 7
Dependent Claim
25 words
The device of claim 5 wherein said polymeric insert contains pores having a molecular weight exclusion range from about 25 kD to about 100 kD.
Claim 8
Dependent Claim
13 words
The device of claim 1 wherein said polymeric insert comprises a hydrophobic matrix.
Claim 9
Dependent Claim
14 words
The device of claim 7 wherein said hydrophobic matrix comprises an ethylene-vinyl acetate copolymer.
Claim 10
Dependent Claim
13 words
The device of claim 1 wherein said polymeric insert comprises a hydrophilic matrix.
Claim 11
Dependent Claim
12 words
The device of claim 9 wherein said hydrophilic matrix comprises a hydrogel.
Claim 12
Dependent Claim
40 words
The device of claim 1 wherein said polymeric insert further comprises an outer coating impermeable to said neurotransmitter, said coating covering a portion of said insert for the controlled release of said neurotransmitter from the uncoated portion of said insert.
Claim 13
Dependent Claim
12 words
The device of claim 11 wherein said impermeable outer coating comprises polyurethane.
Claim 14
Dependent Claim
13 words
The device of claim 11 wherein said impermeable outer coating comprises ethylene-vinyl acetate.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-10-20 | 1996-04-20 | 1996-10-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-10-20 | 2000-04-20 | 2000-10-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-10-20 | 2004-04-20 | 2004-10-20 | $7700.00 | Window Closed / Lapsed |