US5149319A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Methods for providing localized therapeutic heat to biological tissues and fluids
Assignee: Cerevast Therapeutics Inc
•
Filing: 1990-09-11
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Granted: 1992-09-22
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Expires: 2010-09-11
Abstract
Abstract Gas, gaseous precursors and prefluorocarbons are presented as novel potentiators for ultrasonic hyperthermia. The gas, gaseous precursors and perfluorocarbons which may be administered into the vasculature, interstitially or into any body cavity are designed to accumulate in cancerous and diseased tissues. When therapeutic ultrasonic energy is applied to the diseased region heating is increased because of the greater effectiveness of sound energy absorption caused by these agents.
Inventors
- 👤 Evan C. Unger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 07:58
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; A61K41/00; A61K41/0052; A61N; A61N7/00; A61N7/02; A61P; A61P29/00; A61B; A61B17/00; A61B2017/00681; A61B2017/00707; A61B2017/00716; A61B17/22; A61B2017/22082; A61B2017/22088; A61M; A61M2202/00; A61M2202/04; A61M2202/0468; A61M2202/0476; A61N2007/025
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
59 words
A method for heat treating biological tissues and fluids which comprises: (i) administering to the tissue or fluid to be treated a therapeutically effective amount of a hyperthermia potentiator selected from the group consisting of gas, gaseous precursors and perfluorocarbons; and (ii) applying ultrasound to heat said tissue or fluid to a temperature of at least about 43° C.
Claim 2
Independent Claim
59 words
A method for heat treating biological tissues and fluids which comprises: (i) administering to the tissue or fluid to be treated a therapeutically effective amount of a hyperthermia potentiator selected from the group consisting of gas, gaseous precursors and perfluorocarbons; and (ii) applying ultrasound to heat said tissue or fluid to a temperature of at least about 43° C.
Claim 3
Dependent Claim
21 words
A method of claim 1 wherein said hyperthermia potentiator is selected from the group consisting of gas, gaseous precursors and perfluorocarbons.
Claim 4
Dependent Claim
11 words
A method of claim 2 wherein said hyperthermia potentiator is gas.
Claim 5
Dependent Claim
25 words
A method of claim 3 wherein said gas is selected from the group consisting of air, carbon dioxide, oxygen, nitrogen, xenon, argon, neon and helium.
Claim 6
Dependent Claim
13 words
A method of claim 3 wherein said gas consists of stabilized gas bubbles.
Claim 7
Dependent Claim
15 words
A method of claim 5 wherein said stabilized gas bubbles consist of stabilized air bubbles.
Claim 8
Dependent Claim
13 words
A method of claim 2 wherein said hyperthermia potentiator is a gaseous precursor.
Claim 9
Dependent Claim
23 words
A method of claim 7 wherein said gaseous precursor is selected from the group consisting of aminomalonate, sodium bicarbonate, methylactate and diazonium compounds.
Claim 10
Dependent Claim
12 words
A method of claim 2 wherein said hyperthermia potentiator is a perfluorocarbon.
Claim 11
Dependent Claim
21 words
A method of claim 9 wherein said perfluorocarbon is selected from the group consisting of perfluorooctyl iodide, perfluorotributylamine, trifluoropropylamine or perfluorooctlybromide.
Claim 12
Dependent Claim
14 words
A method of claim 1 wherein said hyperthermia potentiator is encapsulated in a liposome.
Claim 13
Dependent Claim
14 words
A method of claim 3 wherein said hyperthermia potentiator is encapsulated in a liposome.
Claim 14
Dependent Claim
14 words
A method of claim 7 wherein said hyperthermia potentiator is encapsulated in a liposome.
Claim 15
Dependent Claim
14 words
A method of claim 9 wherein said hyperthermia potentiator is encapsulated in a liposome.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-09-22 | 1996-03-23 | 1996-09-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-09-22 | 2000-03-23 | 2000-09-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-09-22 | 2004-03-23 | 2004-09-22 | $7700.00 | Window Closed / Lapsed |