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US5122128A Expired / Lapsed US ⏱️ 0.0 years remaining

Orifice insert for a ruminal bolus

Assignee: Alza Corp
•
Filing: 1990-03-15
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Granted: 1992-06-16
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Expires: 2010-03-15
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Abstract

Abstract There is disclosed an insert for the orifice of a ruminal bolus. The insert fits within the exit orifice of the ruminal bolus such that the medicated paste being discharged passes through the insert creating a back pressure within the paste compartment of the bolus which improves the performance of the bolus. The insert also prevents foreign objects from becoming lodged in the orifice. The insert consists of a grid-like series of openings with insert members extending into the orifice for a significant portion of the total length. Integral with the insert is a flange which secures the insert within the orifice and prevents it from being removed from the orifice or from being driven into the orifice.

Inventors

  • 👤 John R. Cardinal
  • 👤 Paul K. Wilkinson
  • 👤 Joel R. Zingerman

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 12:30
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/0068; A61K9/20; A61K9/0002; A61K9/0004; A61M; A61M31/00

Claims Analysis

Total Claims: 12
Claim 1
Independent Claim 227 words
An improved controlled release bolus comprising a semipermeable membrane defining a compartment, the compartment being divided into first and second portions by a moveable interface, the first compartment portion containing a swellable osmotic agent, the second compartment portion containing a medicament to be dispensed, a densifier within the second compartment adjacent the membrane and an orifice having an inside cross-section shape and extending through the membrane and the densifier to connect the second compartment portion with the exterior of the bolus, such that when the bolus is in contact with water, the semipermeable membrane allows water to pass therethrough, which water is imbibed by the swellable osmotic agent which forces the interface to move the medicament to be dispensed through the orifice, wherein the improvement comprises an insert which is placed coaxially within the orifice at the point nearest the exterior of the bolus, said insert comprising (1) an insert portion of the same outside cross-section shape as the inside cross-section shape of the orifice and having a grid-like structure extending the length of the insert providing multiple passageways through the insert and the insert portion, and (2) a cap portion integral with the insert portion and of a greater diameter than the insert portion and shaped to allow for attachment means to the area of the bolus surrounding the orifice where the orifice exits the bolus.
Claim 2
Dependent Claim 227 words
An improved controlled release bolus comprising a semipermeable membrane defining a compartment, the compartment being divided into first and second portions by a moveable interface, the first compartment portion containing a swellable osmotic agent, the second compartment portion containing a medicament to be dispensed, a densifier within the second compartment adjacent the membrane and an orifice having an inside cross-section shape and extending through the membrane and the densifier to connect the second compartment portion with the exterior of the bolus, such that when the bolus is in contact with water, the semipermeable membrane allows water to pass therethrough, which water is imbibed by the swellable osmotic agent which forces the interface to move the medicament to be dispensed through the orifice, wherein the improvement comprises an insert which is placed coaxially within the orifice at the point nearest the exterior of the bolus, said insert comprising (1) an insert portion of the same outside cross-section shape as the inside cross-section shape of the orifice and having a grid-like structure extending the length of the insert providing multiple passageways through the insert and the insert portion, and (2) a cap portion integral with the insert portion and of a greater diameter than the insert portion and shaped to allow for attachment means to the area of the bolus surrounding the orifice where the orifice exits the bolus.
Claim 3
Dependent Claim 16 words
The bolus of claim 1 wherein the passageways are of a square or circular cross-sectional shape.
Claim 4
Dependent Claim 19 words
The bolus of claim 1 wherein the insert portion has the same diameter as the diameter of the orifice.
Claim 5
Dependent Claim 33 words
The bolus of claim 1 wherein the insert portion and the section of the orifice which contacts the insert portion have a greater diameter than the diameter of the remainder of the orifice.
Claim 6
Dependent Claim 20 words
The bolus of claim 1 wherein the insert portion extends from 10% to 100% of the length of the orifice.
Claim 7
Dependent Claim 20 words
The bolus of claim 5 wherein the insert portion extends from 10% to 25% of the length of the orifice.
Claim 8
Dependent Claim 18 words
The bolus of claim 6 wherein the insert portion extends about 12% of the length of the orifice.
Claim 9
Dependent Claim 20 words
The bolus of claim 1 wherein the lower edge of the grid-like structure has a squared-off, beveled or rounded cross-section.
Claim 10
Dependent Claim 17 words
The bolus of claim 8 wherein the lower edge of the grid-like structure has a beveled cross-section.
Claim 11
Dependent Claim 28 words
The bolus of claim 1 wherein the ratio of the cross-sectional area of the grid-like structure to the cross-sectional area of the passageways is from 2:1 to 1:2.
Claim 12
Dependent Claim 11 words
The bolus of claim 10 wherein the ratio is about 1:1.

References Cited (Backward Citations)

US3760804A Cited
US3995632A Cited
US4425117A Cited
US4312347A Cited
US4416659A Cited
US4772474A Cited
EP0321043A1 Cited
US4872873A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1995-06-16 1995-12-16 1996-06-16 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1999-06-16 1999-12-16 2000-06-16 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2003-06-16 2003-12-16 2004-06-16 $7700.00 Window Closed / Lapsed

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