US5116575A — Powdered anti-microbial composition

Claim 1

Independent Claim 120 words

A method of microbially decontaminating items, the method comprising: measuring selected quantities of powdered ingredients, which powdered ingredients include: a powdered borate, and a powdered water soluble acid precurser, which reacts in water to form a oxidant of sufficient strength to kill at least pathogenic microorganisms, an organic corrosion inhibitor, and a borate corrosion inhibitor; sealing the powdered ingredients in an ampule until an item is to be microbially decontaminated; opening the ampule and dissolving and reacting the powdered ingredients in a water containing liquid to form an anti-microbially effective solution of the oxidant, the borate corrosion inhibitor, and the organic corrosion inhibitor; immersing the item in the solution at least until pathogenic microorganisms are killed; and, rinsing the item.

Claim 2

Independent Claim 120 words

A method of microbially decontaminating items, the method comprising: measuring selected quantities of powdered ingredients, which powdered ingredients include: a powdered borate, and a powdered water soluble acid precurser, which reacts in water to form a oxidant of sufficient strength to kill at least pathogenic microorganisms, an organic corrosion inhibitor, and a borate corrosion inhibitor; sealing the powdered ingredients in an ampule until an item is to be microbially decontaminated; opening the ampule and dissolving and reacting the powdered ingredients in a water containing liquid to form an anti-microbially effective solution of the oxidant, the borate corrosion inhibitor, and the organic corrosion inhibitor; immersing the item in the solution at least until pathogenic microorganisms are killed; and, rinsing the item.

Claim 3

Independent Claim 95 words

A method of microbially decontaminating items, the method comprising: measuring selected quantities of dry reagents, which dry reagents includes an acetylsalicylic acid precursor and a sodium perborate peracid, sealing the dry ingredients in an ampule until an item is to microbially decontaminated; opening the ampule and dissolving the dry reagents in a water containing liquid such that an anti-microbially effective solution of a peracetic acid and a borate and salicylic acid corrosion inhibitor are formed; immersing the item in the solution for a duration sufficient to kill at least pathogenic microbes; and, rinsing the item.

Claim 4

Independent Claim 95 words

A method of microbially decontaminating items, the method comprising: measuring selected quantities of dry reagents, which dry reagents includes an acetylsalicylic acid precursor and a sodium perborate peracid, sealing the dry ingredients in an ampule until an item is to microbially decontaminated; opening the ampule and dissolving the dry reagents in a water containing liquid such that an anti-microbially effective solution of a peracetic acid and a borate and salicylic acid corrosion inhibitor are formed; immersing the item in the solution for a duration sufficient to kill at least pathogenic microbes; and, rinsing the item.

Claim 5

Dependent Claim 47 words

The method as set forth in claim 2 wherein the acetylsalicylic acid and sodium perborate are present in appropriate proportions tot eh water such that a chemical reaction in accordance with: ##STR2## occurs and the resultant solution has at least a 0.02% w/v concentration of peracetic acid.

Claim 6

Independent Claim 117 words

A method of sterilizing items, the method comprising: measuring selected quantities of powdered, which the powder ingredients include a mixture of at least one of: K 2 Cr 2 O 7 , NaCl, and H 3 PO 4 ; NaBO 3 and H 3 PO 4 ; and NaClO 2 and LiClO; and acetylsalicylic acid and a perborate; sealing the powdered ingredients in an ampule; opening the ampule and reacting the powdered ingredients in a water containing solution such that an anti-microbially effective solution of an oxidant which kills microorganisms and a inorganic corrosion inhibitor if formed; immersing the item in the solution for a sufficient duration to kill microorganisms on the item; and, rinsing the item.

Claim 7

Independent Claim 117 words

A method of sterilizing items, the method comprising: measuring selected quantities of powdered, which the powder ingredients include a mixture of at least one of: K 2 Cr 2 O 7 , NaCl, and H 3 PO 4 ; NaBO 3 and H 3 PO 4 ; and NaClO 2 and LiClO; and acetylsalicylic acid and a perborate; sealing the powdered ingredients in an ampule; opening the ampule and reacting the powdered ingredients in a water containing solution such that an anti-microbially effective solution of an oxidant which kills microorganisms and a inorganic corrosion inhibitor if formed; immersing the item in the solution for a sufficient duration to kill microorganisms on the item; and, rinsing the item.

Claim 8

Independent Claim 116 words

A method of disinfecting items, the method comprising: measuring selected quantities of powdered ingredients, the powdered ingredients including a mixture of an acetylsalicylic acid precursor and at least one of (i) NaBO 3 , (ii) NaBP 3 and NaCl, and (iii) a powdered salt that forms an inorganic corrosion inhibitor when the mixture reacts in water; sealing the powdered ingredients in an ampule until an item is to be disinfected; opening the ampule and reacting the powdered ingredients in a liquid such that an anti-microbially effective solution of a peracetic acid oxidant, an inorganic corrosion inhibitor, and a salicylic organic corrosion inhibitor are formed; immersing the item in the solution until disinfected; and, rinsing the item.

Claim 9

Independent Claim 116 words

A method of disinfecting items, the method comprising: measuring selected quantities of powdered ingredients, the powdered ingredients including a mixture of an acetylsalicylic acid precursor and at least one of (i) NaBO 3 , (ii) NaBP 3 and NaCl, and (iii) a powdered salt that forms an inorganic corrosion inhibitor when the mixture reacts in water; sealing the powdered ingredients in an ampule until an item is to be disinfected; opening the ampule and reacting the powdered ingredients in a liquid such that an anti-microbially effective solution of a peracetic acid oxidant, an inorganic corrosion inhibitor, and a salicylic organic corrosion inhibitor are formed; immersing the item in the solution until disinfected; and, rinsing the item.

Claim 10

Independent Claim 118 words

A method of microbially decontaminating items, the method comprising: measuring selected quantities of powdered ingredients which form an oxidant that kills at least pathogenic microorganisms when mixed with a dissolving liquid and at least one corrosion inhibitor from the class consisting essentially of: benzotriazoles, tolytriazoles, mercaptobensathiozol, azoles, bensoate, molybdates, phosphates, chromates, dichromates, tungstate, vanadate, and borate; sealing the powdered ingredients in an ampule until an item is to be microbially decontaminated; opening the ampule and dissolving the powdered ingredients in the dissolving liquid such that an anti-microbially effective solution of the pathogenic microorganism killing oxidant and corrosion inhibitors is formed; immersing the item in the solution at lest until the pathogenic microorgansism are killed; and, rinsing the item.

Claim 11

Independent Claim 118 words

A method of microbially decontaminating items, the method comprising: measuring selected quantities of powdered ingredients which form an oxidant that kills at least pathogenic microorganisms when mixed with a dissolving liquid and at least one corrosion inhibitor from the class consisting essentially of: benzotriazoles, tolytriazoles, mercaptobensathiozol, azoles, bensoate, molybdates, phosphates, chromates, dichromates, tungstate, vanadate, and borate; sealing the powdered ingredients in an ampule until an item is to be microbially decontaminated; opening the ampule and dissolving the powdered ingredients in the dissolving liquid such that an anti-microbially effective solution of the pathogenic microorganism killing oxidant and corrosion inhibitors is formed; immersing the item in the solution at lest until the pathogenic microorgansism are killed; and, rinsing the item.

Claim 12

Independent Claim 129 words

A method of microbially decontaminating items, the method comprising: measuring selected quantities of powdered ingredients which dissolve and react to form an oxidant which is sufficiently strong to kill at least pathogenic microorganisms and at least one organic corrosion inhibitor from the class consisting essentially of: benzotriazoles, tolytriazoles, mercaptobenzathiozol, azoles, imidazoles, thiozoles, indoles, pyrazoles, and benzoate; and at least on inorganic corrosion inhibitor from the class consisting essentially of: molybdates, phosphates, chromates, dichromates, tungstate, silicates, vanadate, and borate; sealing the powdered ingredients in an ampule; opening the ampule and dissolving the powdered ingredients and reacting the dissolved ingredients to form an anti-microbially effective solution of the pathogenic microorganism killing oxidant and corrosion inhibitors; immersing the item in the solution until the pathogenic microorganisms are killed; and, rinsing the item.

Claim 13

Independent Claim 129 words

A method of microbially decontaminating items, the method comprising: measuring selected quantities of powdered ingredients which dissolve and react to form an oxidant which is sufficiently strong to kill at least pathogenic microorganisms and at least one organic corrosion inhibitor from the class consisting essentially of: benzotriazoles, tolytriazoles, mercaptobenzathiozol, azoles, imidazoles, thiozoles, indoles, pyrazoles, and benzoate; and at least on inorganic corrosion inhibitor from the class consisting essentially of: molybdates, phosphates, chromates, dichromates, tungstate, silicates, vanadate, and borate; sealing the powdered ingredients in an ampule; opening the ampule and dissolving the powdered ingredients and reacting the dissolved ingredients to form an anti-microbially effective solution of the pathogenic microorganism killing oxidant and corrosion inhibitors; immersing the item in the solution until the pathogenic microorganisms are killed; and, rinsing the item.

Claim 14

Dependent Claim 25 words

The method as set forth in claim 7 wherein the powdered ingredients further include a water soluble acid precursor and a water soluble peroxy compound.

Claim 15

Independent Claim 115 words

A method of sterilizing items, the method comprising: measuring selected quantities of powdered reagents which form a strong oxidant which is effective to kill microorganisms when dissolved; sealing the powdered reagents in an ampule; disposing the item to be sterilized in a closed basin; opening the ampule, dissolving the powdered ingredients, and reacting the dissolved ingredients to form a sterilant solution, the dissolving and reacting steps including recirculating the sterilant solution from a drain end of the basin through interconnecting tubing and back to a basin inlet until microorganisms on the item, in the basin, and in the interconnecting tubing are killed, whereby the interconnecting tubing is sterilized with the item; and rinsing the item.

Claim 16

Independent Claim 115 words

A method of sterilizing items, the method comprising: measuring selected quantities of powdered reagents which form a strong oxidant which is effective to kill microorganisms when dissolved; sealing the powdered reagents in an ampule; disposing the item to be sterilized in a closed basin; opening the ampule, dissolving the powdered ingredients, and reacting the dissolved ingredients to form a sterilant solution, the dissolving and reacting steps including recirculating the sterilant solution from a drain end of the basin through interconnecting tubing and back to a basin inlet until microorganisms on the item, in the basin, and in the interconnecting tubing are killed, whereby the interconnecting tubing is sterilized with the item; and rinsing the item.

Claim 17

Dependent Claim 66 words

The method as set forth in claim 9 wherein the rinsing step further includes passing a sterile rinse liquid from a source of the sterile rinse liquid through the sterilized interconnecting tubing such that the sterile rinse liquid passes only in contact with surfaces that were sterilized by the sterilizing solution, whereby the sterile rinse liquid is prevented from carrying microbial contamination to the sterilized item.

Claim 18

Dependent Claim 15 words

The method as set forth in claim 10 wherein the item is a medical instrument.

Claim 19

Independent Claim 70 words

A method of microbially decontaminating medical instruments, the method comprising: dissolving and reacting powdered acetylsalicylic acid and a powdered perborate in water to form a peracetic acid solution of at least 0.001% w/v of peracetic acid, a borate corrosion inhibitor, and a salicylic organic corrosion inhibitor; immersing the medical instrument in the peracetic acid, borate corrosion inhibitor, and salicylic organic corrosion inhibitor solution until at least pathogenic microorganisms are killed.

Claim 20

Independent Claim 70 words

A method of microbially decontaminating medical instruments, the method comprising: dissolving and reacting powdered acetylsalicylic acid and a powdered perborate in water to form a peracetic acid solution of at least 0.001% w/v of peracetic acid, a borate corrosion inhibitor, and a salicylic organic corrosion inhibitor; immersing the medical instrument in the peracetic acid, borate corrosion inhibitor, and salicylic organic corrosion inhibitor solution until at least pathogenic microorganisms are killed.

Claim 21

Dependent Claim 116 words

A microbial decontamination apparatus comprising: a receiving region for receiving dry reagents which react in water to form a microorganism killing oxidant solution; a plurality of disposable ampules, each ampule holding a preselected dose of the dry reagents to be emptied into the reagent receiving region; interconnecting tubing for interconnecting the dry reagent receiving region with a pump, a basin for receiving an item to be microbially decontaminated, and a water supply, such that water from the water supply selectively flows through and dissolves the dry reagents in the reagent receiving region forming the microorganism killing oxidant solution and such that the pump selectively pumps the microorganism killing solution through the interconnecting tubing into the basin.

Claim 22

Dependent Claim 116 words

A microbial decontamination apparatus comprising: a receiving region for receiving dry reagents which react in water to form a microorganism killing oxidant solution; a plurality of disposable ampules, each ampule holding a preselected dose of the dry reagents to be emptied into the reagent receiving region; interconnecting tubing for interconnecting the dry reagent receiving region with a pump, a basin for receiving an item to be microbially decontaminated, and a water supply, such that water from the water supply selectively flows through and dissolves the dry reagents in the reagent receiving region forming the microorganism killing oxidant solution and such that the pump selectively pumps the microorganism killing solution through the interconnecting tubing into the basin.

Claim 23

Dependent Claim 57 words

The apparatus as set forth in claim 13 further including a sterilizing means operatively connected with the water supply for sterilizing water supplied to the interconnecting tubing and a drain for selectively draining liquid from the interconnecting tubing such that the tubing selectively directs a sterile rinse liquid through the basin to rinse a microbially decontaminated item.

Claim 24

Dependent Claim 23 words

The apparatus as set forth in claim 14 wherein the powdered reagents include a water soluble acid precursor and a water soluble peracid.

Claim 25

Dependent Claim 29 words

The apparatus as set forth in claim 15 wherein the acid precursor is acetylsalicylic acid and the peracid is sodium perborate such that the strong oxidant is peracetic acid.

Claim 26

Dependent Claim 169 words

A microbial decontamination apparatus comprising: a plurality of disposable ampules, each ampule having a preselected dose of powdered reagents including a mixture of at least one of: (i) K 2 Cr 2 O 7 , NaCl, and H 3 PO 4 powders, (ii) NaBO 3 and H 3 PO 4 powders, (iii) NaClO 2 and LiClO powders, (iv) acetylsalicylic acid precursor and borate peracid powders; a receiving region for receiving the powdered reagents and reacting the powdered reagents with water to form an oxidant and corrosion inhibitor solution; interconnecting tubing for interconnecting the powdered reagent receiving region with a pump, a basin for receiving an item to be microbially decontaminated, and a water supply, such that water from the water supply selectively flows through and reacts the powdered reagents in the reagent receiving region forming the oxidant and corrosion inhibitor solution and such that the pump selectively pumps the oxidant and corrosion inhibitor solution through the interconnecting tubing into the basin microbially decontaminating the interconnecting tubing and the item.

Claim 27

Dependent Claim 169 words

A microbial decontamination apparatus comprising: a plurality of disposable ampules, each ampule having a preselected dose of powdered reagents including a mixture of at least one of: (i) K 2 Cr 2 O 7 , NaCl, and H 3 PO 4 powders, (ii) NaBO 3 and H 3 PO 4 powders, (iii) NaClO 2 and LiClO powders, (iv) acetylsalicylic acid precursor and borate peracid powders; a receiving region for receiving the powdered reagents and reacting the powdered reagents with water to form an oxidant and corrosion inhibitor solution; interconnecting tubing for interconnecting the powdered reagent receiving region with a pump, a basin for receiving an item to be microbially decontaminated, and a water supply, such that water from the water supply selectively flows through and reacts the powdered reagents in the reagent receiving region forming the oxidant and corrosion inhibitor solution and such that the pump selectively pumps the oxidant and corrosion inhibitor solution through the interconnecting tubing into the basin microbially decontaminating the interconnecting tubing and the item.

Claim 28

Dependent Claim 43 words

The apparatus as set forth in claim 17 wherein the powdered reagents further include at least one corrosion inhibitor selected from the group consisting of: benzotriazoles, tolytriazoles, mercaptobenzathiozol, axoles, imidazoles, thiozoles, indoles, pyrazoles, benzoate, molybdates, phosphates, chromates, dichromates, tungstate, silicates, vanadate, and borate.

Claim 29

Dependent Claim 71 words

An ampule for supplying a premeasured dose of powdered reagents to sterilize an item in one cycle of an automated sterilizing apparatus, the ampule containing acetylsalicylic acid powder and a borate powder such that when the powdered reagents are mixed with water, they react to form a corrosion inhibiting antimicrobial solution of peracetic acid antimicrobial agent and a borate inorganic corrosion inhibitor, and a salicylic acid corrosion inhibitor in the water.

Claim 30

Dependent Claim 71 words

An ampule for supplying a premeasured dose of powdered reagents to sterilize an item in one cycle of an automated sterilizing apparatus, the ampule containing acetylsalicylic acid powder and a borate powder such that when the powdered reagents are mixed with water, they react to form a corrosion inhibiting antimicrobial solution of peracetic acid antimicrobial agent and a borate inorganic corrosion inhibitor, and a salicylic acid corrosion inhibitor in the water.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1995-05-26	1995-11-25	1996-05-26	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1999-05-26	1999-11-25	2000-05-26	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2003-05-26	2003-11-25	2004-05-26	$7700.00	Window Closed / Lapsed

Powdered anti-microbial composition

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