US5116371A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Prosthesis with improved biocompatibility
Assignee: MMC/GATX PARTNERSHIP NO 1
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Filing: 1990-07-06
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Granted: 1992-05-26
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Expires: 2010-07-06
Abstract
Abstract An implantable prosthesis comprises a hydrogel enclosed within a flexible envelope. The hydrogel contains both hydrophilic and hydrophobic domains. It is prepared by copolymerizing a hydrophilic monomer such as water soluble N-vinylpyrrolidone, acrylates or methacrylates with non-water soluble monomers such as acrylates, methacrylates, N-vinyl carbazole, its derivatives, or a non-water soluble derivative of N-vinylpyrrolidone. The flexible envelope may be either porous or non-porous. The hydrogel may be either solid or composed of particles of a size greater than the porosity of the envelope.
Inventors
- 👤 James M. Christensen
- 👤 Parviz R. Ainpour
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:32
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/52; A61F; A61F2/00; A61F2/02; A61F2/12; A61L27/14; A61L27/16; A61L27/28; A61L27/34; A61F2/0059
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
44 words
A surgically implantable prosthesis comprising at least an outer flexible envelope having enclosed therein a hydrogel having both hydrophobic and hydrophilic regions wherein the improvement consists of hydrophobic regions selected from the group consisting of polymerized N-vinylic hydrophobic monomers, hydrolyzed polyacrylonitriles, and combinations thereof.
Claim 2
Dependent Claim
44 words
A surgically implantable prosthesis comprising at least an outer flexible envelope having enclosed therein a hydrogel having both hydrophobic and hydrophilic regions wherein the improvement consists of hydrophobic regions selected from the group consisting of polymerized N-vinylic hydrophobic monomers, hydrolyzed polyacrylonitriles, and combinations thereof.
Claim 3
Dependent Claim
27 words
The prosthesis of claim 1 wherein the hydrophobic regions of the hydrogel are held together with hydrophobic, ionic, dipolar, hydrogen bonding or a combination of these forces.
Claim 4
Dependent Claim
17 words
The prosthesis of claim 1 wherein at least the outer envelope is constructed of a non-porous material.
Claim 5
Dependent Claim
20 words
The prosthesis of claim 3 wherein the hydrogel filling is a blend of hydrogel particles dispersed in a liquid carrier.
Claim 6
Dependent Claim
19 words
The prosthesis of claim 1 wherein at least the outer envelope is constructed of a porous or semi-permeable material.
Claim 7
Dependent Claim
24 words
The prosthesis of claim 5 wherein the porosity of the outer envelope is designed to allow fluid interchange without large molecule or cellular infiltration.
Claim 8
Dependent Claim
22 words
The prosthesis of claim 5 wherein the outer envelope is designed to allow a controlled amount of tissue ingrowth and capsule formation.
Claim 9
Dependent Claim
20 words
The prosthesis of claim 5 wherein the outer envelope is constructed of a woven, knitted, felted, veloured, or foamed fabric.
Claim 10
Dependent Claim
22 words
The prosthesis of claim 5 wherein the outer envelope is constructed of a stretched or expanded material to create porosity or permeability.
Claim 11
Dependent Claim
31 words
The prosthesis of claim 1 further comprising an inner envelope enclosed within the outer envelope wherein at least the space between the inner and outer envelopes is filled with the hydrogel.
Claim 12
Dependent Claim
24 words
The prosthesis of claim 5 wherein the hydrogel filling is composed of particles having a size larger than the porosity of the outer envelope.
Claim 13
Dependent Claim
22 words
The prosthesis of claim 1 wherein the hydrogel is prepared by the copolymerization of a hydrophilic monomer with a N-vinylic hydrophobic monomer.
Claim 14
Dependent Claim
13 words
The prosthesis of claim 1 for use in augmenting or replacing breast tissue.
Claim 15
Dependent Claim
39 words
A surgically implantable prosthesis comprising at least an outer flexible envelope having enclosed therein a hydrogel having both hydrophobic and hydrophilic regions wherein the hydrogel is prepared by the copolymerization of a hydrophilic monomer with a N-vinylic hydrophobic monomer.
Claim 16
Dependent Claim
39 words
A surgically implantable prosthesis comprising at least an outer flexible envelope having enclosed therein a hydrogel having both hydrophobic and hydrophilic regions wherein the hydrogel is prepared by the copolymerization of a hydrophilic monomer with a N-vinylic hydrophobic monomer.
Claim 17
Dependent Claim
106 words
The prosthesis of claim 14 wherein the hydrophilic monomer is a water soluble vinylic compound of the formula ##STR5## wherein R is H or CH 3 , R' is CH 2 --CH 2 --OH, CH 2 --CH(CH 3 )--OH, or CH 3 --CH(OH)--CH 2 --OH and R" and R"' are H, CH 3 , C 2 H 5 , or CH 2 --CH(OH)--CH 3 and the hydrophobic monomer is a non-water soluble compound of the formula RR'--N--CH═CH.sub.2. where R or R' are hydrophobic compounds selected from the group consisting of N-vinylcarbazole, its derivatives, non-water soluble derivatives of N-vinylpyrrolidone, aromatic derivatives of N-vinylpyrrolidone, N-vinylcarbazole, and their derivatives.
Claim 18
Dependent Claim
31 words
A surgically implantable prosthesis comprising at least one flexible envelope having enclosed therein a hydrogel wherein the hydrogel comprises a hydrolyzed polyacrylonitrile having both carboxylic or amide groups and nitrile groups.
Claim 19
Dependent Claim
31 words
A surgically implantable prosthesis comprising at least one flexible envelope having enclosed therein a hydrogel wherein the hydrogel comprises a hydrolyzed polyacrylonitrile having both carboxylic or amide groups and nitrile groups.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-05-26 | 1995-11-25 | 1996-05-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-05-26 | 1999-11-25 | 2000-05-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-05-26 | 2003-11-25 | 2004-05-26 | $7700.00 | Window Closed / Lapsed |