US5111820A
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System and method for magnetic resonance imaging of 3-dimensional heart wall motion with spatial modulation of magnetization
Assignee: TRUSTEES OF UNIVERSITY OF PENNSYLVANIA A NON-PROFIT CORP OF
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Filing: 1990-11-02
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Granted: 1992-05-12
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Expires: 2010-11-02
Abstract
Abstract Spatial Modulation of Magnetization (SPAMM) with two sets of tagging planes orthogonal to the image plane is used in accordance with known techniques to image two-dimensional heart wall motion with MRI. However, such techniques are modified in accordance with the invention to permit direct assessment of three-dimensional heart wall motion from two-dimensional images using a three-dimensional SPAMM technique and a phase shift SPAMM technique. The three-dimensional SPAMM technique uses a third set of tagging planes oblique to the image plane to separate within-plane motion from through-plane motion. In accordance with the 3-dimensional SPAMM technique, the displacement of the oblique magnetization lines relative to the displacement of the spatial modulation pattern in the imaging plane during a preimaging time interval is indicative of the displacement of a body portion such as a patient's heart wall through the imaging plane during the preimaging time interval. Preferably, the oblique angle is 45° so that the amount of stripe displacement is equal to the amount of through-plane-motion. On the other hand, the phase-shift SPAMM technique encodes through-plane velocity as a corresponding phase shift. An integral may then be taken of the resulting phase-sensitized images in order to determine the through-plane displacement corresponding to the phase shift. Both techniques in accordance with the invention allow three-dimensional images of internal body tissues such as the heart wall to be imaged with minimal image acquisition and interpolation time.
Inventors
- 👤 Leon Axel
- 👤 Lawrence Dougherty
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:10
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/54; G01R33/56; G01R33/563; G01R33/56308; G01R33/56333
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
137 words
A method of magnetic resonance imaging of a body portion of a patient, comprising the steps of: applying to the body portion an external magnetic field so as to produce a resultant magnetization; applying a pre-imaging sequence to the body portion so as to spatially modulate transverse and longitudinal components of the resultant magnetization, thereby producing a spatial modulation pattern in an imaging plane; applying an imaging sequence to the body portion; providing an image representing magnetic resonance signals having said spatial modulation pattern and a displacement of said modulation pattern through said imaging plane as emitted from the patient; and determining said displacement of said modulation pattern through said imaging plane in a direction substantially perpendicular to said imaging plane during a pre-imaging time interval between the times of application of said pre-imaging and imaging sequences.
Claim 2
Independent Claim
137 words
A method of magnetic resonance imaging of a body portion of a patient, comprising the steps of: applying to the body portion an external magnetic field so as to produce a resultant magnetization; applying a pre-imaging sequence to the body portion so as to spatially modulate transverse and longitudinal components of the resultant magnetization, thereby producing a spatial modulation pattern in an imaging plane; applying an imaging sequence to the body portion; providing an image representing magnetic resonance signals having said spatial modulation pattern and a displacement of said modulation pattern through said imaging plane as emitted from the patient; and determining said displacement of said modulation pattern through said imaging plane in a direction substantially perpendicular to said imaging plane during a pre-imaging time interval between the times of application of said pre-imaging and imaging sequences.
Claim 3
Dependent Claim
15 words
A method as in claim 1, wherein said body portion is the patient's heart wall.
Claim 4
Dependent Claim
14 words
A method as in claim 1, wherein said body portion is the patient's blood.
Claim 5
Dependent Claim
15 words
A method as in claim 1, wherein said body portion is the patient's cerebrospinal fluid.
Claim 6
Dependent Claim
93 words
A method as in claim 1, wherein said pre-imaging sequence applying step comprises the step of modulating said resultant magnetization to produce oblique magnetization lines in the body portion which are oriented at an oblique angle to said imaging plane, and said determining step comprises the step of determining a displacement of said oblique magnetization lines relative to a displacement of said spatial modulation pattern in said imaging plane during said pre-imaging time interval, said relative displacement indicating a displacement of said body portion through said imaging plane during said pre-imaging time interval.
Claim 7
Dependent Claim
12 words
A method as in claim 5, wherein said oblique angle is 45°.
Claim 8
Dependent Claim
88 words
A method as in claim 1, wherein said pre-imaging sequence applying step comprises the step of encoding motion through said imaging plane during said pre-imaging time interval as motion-induced phase shifts caused by motion of excited nuclear spins along gradients of said resultant magnetization, thereby producing a phase-sensitized modulation pattern in said imaging plane, and said determining step comprises the step of integrating said phase-sensitized modulation pattern to get a signal indicative of a displacement of said body portion through said imaging plane during said pre-imaging time interval.
Claim 9
Independent Claim
147 words
A method of magnetic resonance imaging a heart wall of a patient for detecting motion of said heart wall, comprising the steps of: applying to the heart wall an external magnetic field so as to produce a resultant magnetization; applying a pre-imaging sequence to the heart wall so as to spatially modulate transverse and longitudinal components of the resultant magnetization, thereby producing a spatial modulation pattern in an imaging plane; applying a cardiac gated spin echo imaging sequence to the heart wall; providing an image representing magnetic resonance signals having said spatial modulation pattern and a displacement of said modulation pattern through said imaging plane as emitted from the patient; and determining said displacement of said modulation pattern through said imaging plane in a direction substantially perpendicular to said imaging plane during a pre-imaging time interval between the times of application of said pre-imaging and imaging sequences.
Claim 10
Independent Claim
147 words
A method of magnetic resonance imaging a heart wall of a patient for detecting motion of said heart wall, comprising the steps of: applying to the heart wall an external magnetic field so as to produce a resultant magnetization; applying a pre-imaging sequence to the heart wall so as to spatially modulate transverse and longitudinal components of the resultant magnetization, thereby producing a spatial modulation pattern in an imaging plane; applying a cardiac gated spin echo imaging sequence to the heart wall; providing an image representing magnetic resonance signals having said spatial modulation pattern and a displacement of said modulation pattern through said imaging plane as emitted from the patient; and determining said displacement of said modulation pattern through said imaging plane in a direction substantially perpendicular to said imaging plane during a pre-imaging time interval between the times of application of said pre-imaging and imaging sequences.
Claim 11
Independent Claim
144 words
An apparatus for magnetic resonance imaging a body portion of a patient, comprising: means for applying to the body portion an external magnetic field so as to produce a resultant magnetization; imaging means for applying a pre-imaging sequence to the body portion so as to spatially modulate transverse and longitudinal components of the resultant magnetization, thereby producing a spatial modulation pattern in an imaging plane, and for applying an imaging sequence to the body portion; and means for displaying an image representing magnetic resonance signals having said spatial modulation pattern and a displacement of said modulation pattern through said imaging plane as emitted from the patient and for determining said displacement of said modulation pattern through said imaging plane in a direction substantially perpendicular to said imaging plane during a pre-imaging time interval between the times of application of said pre-imaging and imaging sequences.
Claim 12
Independent Claim
144 words
An apparatus for magnetic resonance imaging a body portion of a patient, comprising: means for applying to the body portion an external magnetic field so as to produce a resultant magnetization; imaging means for applying a pre-imaging sequence to the body portion so as to spatially modulate transverse and longitudinal components of the resultant magnetization, thereby producing a spatial modulation pattern in an imaging plane, and for applying an imaging sequence to the body portion; and means for displaying an image representing magnetic resonance signals having said spatial modulation pattern and a displacement of said modulation pattern through said imaging plane as emitted from the patient and for determining said displacement of said modulation pattern through said imaging plane in a direction substantially perpendicular to said imaging plane during a pre-imaging time interval between the times of application of said pre-imaging and imaging sequences.
Claim 13
Dependent Claim
31 words
The apparatus of claim 9, wherein said magnetic field applying means and imaging means are adapted so as to apply said magnetic field and pre-imaging sequence to the patient's heart wall.
Claim 14
Dependent Claim
30 words
The apparatus of claim 9, wherein said magnetic field applying means and imaging means are adapted so as to apply said magnetic field and pre-imaging sequence to the patient's blood.
Claim 15
Dependent Claim
31 words
The apparatus of claim 9, wherein said magnetic field applying means and imaging means are adapted so as to apply said magnetic field and pre-imaging sequence to the patient's cerebrospinal fluid.
Claim 16
Dependent Claim
88 words
The apparatus of claim 9, wherein said imaging means comprises means for modulating said resultant magnetization to produce oblique magnetization lines in the body portion which are oriented at an oblique angle to said imaging plane, and said determining means comprises means for determining a displacement of said oblique magnetization lines relative to a displacement of said spatial modulation pattern in said imaging plane during said pre-imaging time interval, said relative displacement indicating a displacement of said body portion through said imaging plane during said pre-imaging time interval.
Claim 17
Dependent Claim
11 words
The apparatus of claim 13, wherein said oblique angle is 45°.
Claim 18
Dependent Claim
83 words
The apparatus of claim 9, wherein said imaging means comprises means for encoding motion through said imaging plane during said pre-imaging time interval as motion-induced phase shifts caused by motion of excited nuclear spins along gradients of said resultant magnetization, thereby producing a phase-sensitized modulation pattern in said imaging plane, and said determining means comprises means for integrating said phase-sensitized modulation pattern to get a signal indicative of a displacement of said body portion through said imaging plane during said pre-imaging time interval.
Claim 19
Independent Claim
154 words
An apparatus for magnetic resonance imaging a heart wall of a patient for detecting motion of said heart wall, comprising: means for applying to the heart wall and external magnetic field so as to produce a resultant magnetization; imaging means for applying a pre-imaging sequence to the heart wall so as to spatially modulate transverse and longitudinal components of the resultant magnetization, thereby producing a spatial modulation pattern in an imaging plane, and for applying a cardiac gated spin echo imaging sequence to the heart wall; and means for displaying an image representing magnetic resonance signals having said spatial modulation pattern and a displacement of said modulation pattern through said imaging plane as emitted from the patient and determining said displacement of said modulation pattern through said imaging plane in a direction substantially perpendicular to said imaging plane during a pre-imaging time interval between the times of application of said pre-imaging and imaging sequences.
Claim 20
Independent Claim
154 words
An apparatus for magnetic resonance imaging a heart wall of a patient for detecting motion of said heart wall, comprising: means for applying to the heart wall and external magnetic field so as to produce a resultant magnetization; imaging means for applying a pre-imaging sequence to the heart wall so as to spatially modulate transverse and longitudinal components of the resultant magnetization, thereby producing a spatial modulation pattern in an imaging plane, and for applying a cardiac gated spin echo imaging sequence to the heart wall; and means for displaying an image representing magnetic resonance signals having said spatial modulation pattern and a displacement of said modulation pattern through said imaging plane as emitted from the patient and determining said displacement of said modulation pattern through said imaging plane in a direction substantially perpendicular to said imaging plane during a pre-imaging time interval between the times of application of said pre-imaging and imaging sequences.
References Cited (Backward Citations)
US4752734A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-05-12 | 1995-11-11 | 1996-05-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-05-12 | 1999-11-11 | 2000-05-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-05-12 | 2003-11-11 | 2004-05-12 | $7700.00 | Window Closed / Lapsed |