US5092883A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for promoting soft connective tissue growth and repair in mammals
Assignee: Individual
•
Filing: 1990-12-13
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Granted: 1992-03-03
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Expires: 2010-12-13
Abstract
Abstract A material with chemically induced surface charges is employed to foster formation of mammalian hard and soft connective tissues. The material may be in the form of beads such as ion exchange resins. Bead materials with a negative surface charge stimulate formation of hard tissue within long bones and foster bony repair of defects in parietal bones and in mandibular rami. Beads with positively charged surfaces engender formation of large quantities of soft dense connective tissue when implanted into defects in the cranium or when used as an onlay on the nasal bone surface. The use of such beads or other charged biodegradable materials and the use of other surface charged materials with different physical configurations provides significant improvement in hard and soft connective tissue repair, augmentation and replacement in medical fields such as orthopaedic and maxillofacial surgery.
Inventors
- 👤 Barry L. Eppley
- 👤 Marilyn D. Krukowski
- 👤 Philip A. Osdoby
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 02:05
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/58; A61L27/14; A61L27/20; Y; Y10; Y10S; Y10S623/00; Y10S623/915; Y10S623/916; Y10S623/917; Y10S623/919
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
97 words
A method for promoting soft connective tissue growth and repair in sites of tissue defects in living mammals which comprises applying an effective quantity of charged material with a deliberately produced chemically induced effective surface charge to said sites, the tissue being soft connective tissue and the tissue defects being caused by at least one of trauma, malignancy and malformation in said soft connective tissue and said charged material being applied to said site and said material being an ion exchange material having a positive charge, said effective quantity being sufficient to promote said growth and repair.
Claim 2
Independent Claim
97 words
A method for promoting soft connective tissue growth and repair in sites of tissue defects in living mammals which comprises applying an effective quantity of charged material with a deliberately produced chemically induced effective surface charge to said sites, the tissue being soft connective tissue and the tissue defects being caused by at least one of trauma, malignancy and malformation in said soft connective tissue and said charged material being applied to said site and said material being an ion exchange material having a positive charge, said effective quantity being sufficient to promote said growth and repair.
Claim 3
Dependent Claim
11 words
The method of claim 1 in which the material is biodegradable.
Claim 4
Dependent Claim
19 words
The method of claim 1 in which said material is applied in the form of small discrete spherical beads.
Claim 5
Independent Claim
124 words
A method for promoting soft connective tissue growth and repair in site of tissue defects in living mammals which comprises applying an effective quantity of charged material with a deliberately produced chemically induced effective surface charge to said sites, said effective quantity being sufficient to promote said growth and repair, said tissue site being soft connective tissue and the tissue defects being caused by at least one of trauma, malignancy and malformation in said soft connective tissue and said charged material being applied to said site, said charged material having a positive charge and said charged material being applied in the form of small discrete spherical beads, said beads being a biodegradable ion exchange material and comprised of a dextran matrix having functional groups.
Claim 6
Independent Claim
124 words
A method for promoting soft connective tissue growth and repair in site of tissue defects in living mammals which comprises applying an effective quantity of charged material with a deliberately produced chemically induced effective surface charge to said sites, said effective quantity being sufficient to promote said growth and repair, said tissue site being soft connective tissue and the tissue defects being caused by at least one of trauma, malignancy and malformation in said soft connective tissue and said charged material being applied to said site, said charged material having a positive charge and said charged material being applied in the form of small discrete spherical beads, said beads being a biodegradable ion exchange material and comprised of a dextran matrix having functional groups.
Claim 7
Dependent Claim
12 words
The method of claim 4 in which the functional groups comprise diethylamine.
Claim 8
Dependent Claim
18 words
The method of claim 1 in which said material is directly applied to said soft connective tissue sites.
Claim 9
Dependent Claim
35 words
The method of claim 1 in which a fabric, mesh or sheet, containing said charge material is fashioned into an appropriate shape and size, and said fabric, mesh or sheet is placed onto said site.
Claim 10
Dependent Claim
28 words
The method of claim 1 in which the material serves as a vehicle for the introduction of growth factors into soft connective tissue sites for correction of defects.
Claim 11
Dependent Claim
32 words
The method of claim 1 in which the material serves as a vehicle for the introduction of growth factors and other mitogenic proteins into soft connective tissue sites for correction of defects.
Claim 12
Dependent Claim
33 words
The method of claim 1 in which the material is an integral component of alloplastic material that may be used for at least one of soft connective tissue fixation, stabilization, reconstruction and replacement.
Claim 13
Dependent Claim
37 words
The method of claim 1 in which the material is an integral component of alloplastic material that may be used for at least one of soft connective tissue ingrowth into prothesis for fixation, stabilization, reconstruction and replacement.
Claim 14
Independent Claim
123 words
A method for promoting soft connective tissue growth and repair in sites of tissue defects in living mammals which comprises applying an effective quantity of charged material with a deliberately produced chemically induced effective surface charge to said sites, said effective quantity being sufficient to promote said growth and repair, said tissue site being soft connective tissue and the tissue defects being caused by at least one of trauma, malignancy and malformation in said soft connective tissue and said charge material being applied to said site, said charged material having a positive charge and said charged material being applied in the form of small discrete spherical beads, said beads being an ion exchange material and comprised of a dextran matrix having functional groups.
Claim 15
Independent Claim
123 words
A method for promoting soft connective tissue growth and repair in sites of tissue defects in living mammals which comprises applying an effective quantity of charged material with a deliberately produced chemically induced effective surface charge to said sites, said effective quantity being sufficient to promote said growth and repair, said tissue site being soft connective tissue and the tissue defects being caused by at least one of trauma, malignancy and malformation in said soft connective tissue and said charge material being applied to said site, said charged material having a positive charge and said charged material being applied in the form of small discrete spherical beads, said beads being an ion exchange material and comprised of a dextran matrix having functional groups.
Claim 16
Dependent Claim
20 words
The method of claim 1 in which said material is added to the site of a wound for wound repair.
Claim 17
Dependent Claim
18 words
The method of claim 1 in which said material is added to the site by a fat graft.
Claim 18
Dependent Claim
23 words
The method of claim 14 in which said material serves as a vehicle for the introduction of growth factor or other mitogenic protein.
Claim 19
Dependent Claim
16 words
The method of claim 15 in which the growth factor is a basic fibroblast growth factor.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-03-03 | 1995-09-02 | 1996-03-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-03-03 | 1999-09-02 | 2000-03-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-03-03 | 2003-09-02 | 2004-03-03 | $7700.00 | Window Closed / Lapsed |