US5092335A
Expired / Lapsed
US
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Method for the imaging of intra-voxel movements by nmr in a body
Assignee: General Electric CGR SA
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Filing: 1988-10-12
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Granted: 1992-03-03
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Expires: 2008-10-12
Abstract
Abstract Movements within volume elements or voxels of a body are depicted by subjecting this body to sequences of electro-magnetic excitation of the SSFP type during an NMR experiment. It is shown that by performing two series of excitation/reading sequences with different sensitization characteristics, it is possible to obtain images of molecular diffusion and/or perfusions in a far quicker and in a far more differentiated way than with standard types of excitation methods, of the spin-echo type for example.
Inventors
- 👤 Denis Le Bihan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:48
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/54; G01R33/56; G01R33/563; G01R33/56341
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
191 words
A method for the imaging of intra-voxel movements by NMR in a body, comprising the steps of: placing said body to be examined in a constant magnetic field of an NMR apparatus; subjecting said body to a first series of steady state free precession (SSFP) type radio frequency excitation sequences and the presence of phase encoding magnetic field gradients; measuring a magnetic resonance signal emitted by said body, at the end of each sequence of said first series, constructing a first image from said measured magnetic resonance imaging signal; subjecting said body to a series of SSFP type radio frequency excitation sequences having parameters which are the same as parameters of said first series, in the presence of encoding gradients and in the presence of first sensitizing magnetic field gradients which sensitize said body to intra-voxel movements; measuring a second magnetic resonance signal emitted by said body at the end of each sequence of said second series and constructing a second image from said second magnetic resonance signal; and calculating a third image from said first image and said second image, said third image depicting the intra-voxel movements of said body.
Claim 2
Independent Claim
191 words
A method for the imaging of intra-voxel movements by NMR in a body, comprising the steps of: placing said body to be examined in a constant magnetic field of an NMR apparatus; subjecting said body to a first series of steady state free precession (SSFP) type radio frequency excitation sequences and the presence of phase encoding magnetic field gradients; measuring a magnetic resonance signal emitted by said body, at the end of each sequence of said first series, constructing a first image from said measured magnetic resonance imaging signal; subjecting said body to a series of SSFP type radio frequency excitation sequences having parameters which are the same as parameters of said first series, in the presence of encoding gradients and in the presence of first sensitizing magnetic field gradients which sensitize said body to intra-voxel movements; measuring a second magnetic resonance signal emitted by said body at the end of each sequence of said second series and constructing a second image from said second magnetic resonance signal; and calculating a third image from said first image and said second image, said third image depicting the intra-voxel movements of said body.
Claim 3
Dependent Claim
132 words
A method according to claim 1, comprising the further steps of: subjecting said body to a third series of SSFP type radio frequency sequences, in the presence of image encoding magnetic field gradients and the presence of second sensitizing magnetic field gradients; measuring a third magnetic resonance signal emitted by said body at the end of each sequence of said third series; constructing a fourth image from said third measured magnetic resonance signal; calculating a fifth image from said first image and said fourth image, said fifth image depicting intra-voxel movements of the body; calculating at least one of a sixth image and a seventh image from said third image and said fifth images, said sixth image depicting molecular diffusion and said seventh image depicting perfusion of a liquid in said body.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-03-03 | 1995-09-02 | 1996-03-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-03-03 | 1999-09-02 | 2000-03-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-03-03 | 2003-09-02 | 2004-03-03 | $7700.00 | Window Closed / Lapsed |