US5081148A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Blocking agents of edrf effect or formation for the treatment of shock
Assignee: Ipsen Pharma SAS
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Filing: 1990-12-19
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Granted: 1992-01-14
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Expires: 2010-12-19
Abstract
Abstract The invention relates to a therapeutical composition of matter for the treatment by perfusion of shock states comprising as an essential ingredient therein, an effective amount either, of a compound of the formula: ##STR1## wherein R 1 and R 4 stant for H or CH 3 or C 2 H 5 , R 2 stands for H or NO 2 and R 3 stands for NHR 4 or CH 3 or C 2 H 5 alone or of a mixture of said compound with a cyclooxygenase blocker.
Inventors
- 👤 Pierre Braquet
- 👤 Pierre-Etienne Chabrier de Lassauniere
- 👤 Jean-Michel Guillon
- 👤 Michel Auguet
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 20:01
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/19; A61K31/195; A61K31/197; A61K31/198; A61P; A61P39/00; A61P43/00; A61P9/00; A61P9/02; A61P9/10; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
98 words
A therapeutical composition of matter for the treatment by perfusion of shock states comprising as an essential ingredient therein an effective amount of a compound of the formula: ##STR3## wherein R 1 and R 4 stand for H or CH 3 or C 2 H 5 , R 2 stands for H or NO 2 and R 3 stands for NHR 4 or CH 3 or C 2 H 5 with the proviso that R 1 , R 2 and R 4 cannot all be H, together with a cyclooxygenase blocker in an amount sufficient to block cyclooxygenase.
Claim 2
Dependent Claim
98 words
A therapeutical composition of matter for the treatment by perfusion of shock states comprising as an essential ingredient therein an effective amount of a compound of the formula: ##STR3## wherein R 1 and R 4 stand for H or CH 3 or C 2 H 5 , R 2 stands for H or NO 2 and R 3 stands for NHR 4 or CH 3 or C 2 H 5 with the proviso that R 1 , R 2 and R 4 cannot all be H, together with a cyclooxygenase blocker in an amount sufficient to block cyclooxygenase.
Claim 3
Dependent Claim
24 words
The composition of claim 3 containing, as an effective amount, for a one hour perfusion, from 10 to 500 mg of the selected compound.
Claim 4
Dependent Claim
99 words
A therapeutical composition of matter for the treatment by perfusion of shock states comprising as an essential ingredient therein an effective amount of a mixture of a compound of the formula: ##STR4## wherein R 1 and R 4 stand for H or CH 3 or C 2 H 5 , R 2 stands for H or NO 2 and R 3 stands for NHR 4 or CH 3 or C 2 H 5 with the proviso that R 1 , R 2 and R 4 cannot all be H, with a cyclooxygenase blocker selected from within indomethacin and aspirin.
Claim 5
Dependent Claim
99 words
A therapeutical composition of matter for the treatment by perfusion of shock states comprising as an essential ingredient therein an effective amount of a mixture of a compound of the formula: ##STR4## wherein R 1 and R 4 stand for H or CH 3 or C 2 H 5 , R 2 stands for H or NO 2 and R 3 stands for NHR 4 or CH 3 or C 2 H 5 with the proviso that R 1 , R 2 and R 4 cannot all be H, with a cyclooxygenase blocker selected from within indomethacin and aspirin.
Claim 6
Dependent Claim
53 words
The composition of claim 2 containing, as an effective amount of the mixture, for a one hour perfusion, from 10 to 100 mg of the selected compound associated with 0.1 to 1 mg of indomethacin, or with 2 to 200 mg of aspirin or with the corresponding amounts of other blockers of cyclooxygenase.
Claim 7
Dependent Claim
19 words
The composition of claim 3 wherein the cyclooxygenase blocker is indomethacin in the amount of 0.1 to 1 mg.
Claim 8
Dependent Claim
19 words
The composition of claim 3 wherein the cyclooxygenase blocker is aspirin in the amount of 2 to 200 mg.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-01-13 | 1995-07-15 | 1996-01-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-01-13 | 1999-07-15 | 2000-01-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-01-13 | 2003-07-15 | 2004-01-14 | $7700.00 | Window Closed / Lapsed |