US5078885A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method and apparatus for removing protein-bound molecules from body fluids
Assignee: Individual
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Filing: 1988-11-21
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Granted: 1992-01-07
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Expires: 2008-11-21
Abstract
Abstract The method for removing molecules bound to proteins in body fluid comprising positioning said body fluid in contact with one side of an albumin-dimensioned bottle-neck pore membrane and positioning proximate the opposite side of said membrane aqueously suspended adsorbent. The apparatus comprises an albumin-dimensioned bottle-neck pore membrane and means associated therewith for positioning body fluid to be treated in contact with one side of said membrane and aqueously suspended adsorbent located proximate the opposite side of said membrane.
Inventors
- 👤 Kenneth N. Matsumura
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:55
CPC Classifications
B; B01; B01D; B01D61/00; B01D61/24; B01D61/243; A; A61; A61M; A61M1/00; A61M1/14; A61M1/16; A61M1/1621; A61M1/1649; A61M1/36; A61M1/3679; A61M60/00; A61M60/10; A61M60/104; A61M60/109; A61M60/113; A61M60/20; A61M60/247; A61M60/253; A61M60/268; A61M60/279; A61M60/30; A61M60/36; A61M60/37; A61M60/50; A61M60/508; A61M60/562; B01D15/00
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
71 words
In the method comprising positioning body fluid to be treated into contact with one side of a semi-permeable membrane and positioning adsorbent proximate the other side of said membrane, the improvement comprising removing molecules which are bound to proteins in body fluid by positioning said body fluid in contact with one side of an albumin-dimensioned bottle-neck pore membrane and positioning proximate the opposite side of the said membrane aqueously suspended adsorbent.
Claim 2
Dependent Claim
71 words
In the method comprising positioning body fluid to be treated into contact with one side of a semi-permeable membrane and positioning adsorbent proximate the other side of said membrane, the improvement comprising removing molecules which are bound to proteins in body fluid by positioning said body fluid in contact with one side of an albumin-dimensioned bottle-neck pore membrane and positioning proximate the opposite side of the said membrane aqueously suspended adsorbent.
Claim 3
Dependent Claim
32 words
The invention of claim 1 wherein means are provided to cause to-and-fro movements of adsorbents and body fluid proteins partially into and out of the narrow end of pores of said membrane.
Claim 4
Dependent Claim
36 words
The invention of claim 1 wherein adsorbents are placed on the side of said membrane having the narrow bottle-neck end of the pores and the body fluid is placed on the opposite side of said membrane.
Claim 5
Dependent Claim
47 words
The invention of claim 1 wherein the aqueous fluid suspending said adsorbent is removed from contact with said membrane, said adsorbent is chemically treated to remove bound molecules removed from said body fluid, and the aqueous fluid suspending said adsorbent is returned into contact with said membrane.
Claim 6
Dependent Claim
11 words
The invention of claim 1 wherein said adsorbent is liver cells.
Claim 7
Dependent Claim
14 words
The invention of claim 1 wherein said adsorbent is molecular adsorbent and liver cells.
Claim 8
Dependent Claim
11 words
The invention of claim 1 wherein said adsorbent is liver homogenate.
Claim 9
Dependent Claim
12 words
The invention of claim 1 wherein said adsorbent is a designed adsorbent.
Claim 10
Dependent Claim
88 words
In the apparatus comprising a semi-permeable membrane, means associated therewith for positioning body fluid to be treated in contact with one side of said membrane and adsorbents located proximate the opposite side of said membrane, the improvement comprising an albumin-dimensioned bottle-neck pore membrane, means for removing molecules which are bound to proteins in said body fluid, means associated with said membrane for positioning body fluid to be treated in contact with one side of said membrane, and aqueously suspended adsorbent located proximate the opposite side of said membrane.
Claim 11
Dependent Claim
88 words
In the apparatus comprising a semi-permeable membrane, means associated therewith for positioning body fluid to be treated in contact with one side of said membrane and adsorbents located proximate the opposite side of said membrane, the improvement comprising an albumin-dimensioned bottle-neck pore membrane, means for removing molecules which are bound to proteins in said body fluid, means associated with said membrane for positioning body fluid to be treated in contact with one side of said membrane, and aqueously suspended adsorbent located proximate the opposite side of said membrane.
Claim 12
Dependent Claim
31 words
The invention of claim 9 wherein means are provided to cause to-and-fro movements of adsorbent and body fluid protein partially into and out of narrow end of pores of said membrane.
Claim 13
Dependent Claim
58 words
The invention of claim 9 wherein means are provided for withdrawing said aqueous fluid suspending adsorbent from contact with said membrane, additional means are provided for chemical treatment of said adsorbent to remove bound molecules removed from said body fluid, and means are provided to return said treated adsorbent suspended in aqueous fluid into contact with said membrane.
Claim 14
Dependent Claim
11 words
The invention of claim 9 wherein said adsorbent is liver cells.
Claim 15
Dependent Claim
14 words
The invention of claim 9 wherein said adsorbent is molecular adsorbent and liver cells.
Claim 16
Dependent Claim
49 words
The invention of claim 9 wherein said means for positioning adsorbent in contact with said membrane is on the side of the membrane having narrow bottle-neck end of pores and said means for positioning body fluid in contact with said membrane is on the opposite side of said membrane.
Claim 17
Dependent Claim
10 words
The invention of claim 9 wherein adsorbent is designer adsorbent.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-01-06 | 1995-07-08 | 1996-01-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-01-06 | 1999-07-08 | 2000-01-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-01-06 | 2003-07-08 | 2004-01-07 | $7700.00 | Window Closed / Lapsed |