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Mixed crystals of insulin and insulin derivatives
Assignee: Hoechst AG
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Filing: 1988-05-20
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Granted: 1991-07-02
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Expires: 2008-05-20
Abstract
Abstract Mixed crystals composed of (a) unmodified insulin, des-Phe-B1 insulin, des-Thr-B30 (human) or des-Ala-B30 (pork, beef) insulin and (b) least one insulin having a basic modification at the C-terminal end of the B chain, preferably composed of human insulin and Arg-B31 human insulin and/or Arg 2 -(B31-32) human insulin. These mixed crystals are obtained by crystallization from aqueous solution within a narrow pH range (from about 5.5 to about 6.9). The mixed crystals show a specific moderately prolonged profile and are suitable for the treatment of diabetes mellitus.
Inventors
- 👤 Michael Dorschug
- 👤 Rainer Obermeier
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:47
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/22; A61K38/28; A61K9/00; A61K9/14; A61P; A61P3/00; A61P3/08; A61P3/10; C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/62
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
52 words
Mixed crystals composed of consisting essentially of A. unmodified insulin, des-Phe-B1 insulin, human des-ThR-B30 pork des-Ala-B30 insulin or beef des-Ala-B30 insulin and B. An insulin having a basic modification at the C-terminal end of the B chain, wherein the ratio by weight of the two components A and B is about 10-90:90-10.
Claim 2
Dependent Claim
52 words
Mixed crystals composed of consisting essentially of A. unmodified insulin, des-Phe-B1 insulin, human des-ThR-B30 pork des-Ala-B30 insulin or beef des-Ala-B30 insulin and B. An insulin having a basic modification at the C-terminal end of the B chain, wherein the ratio by weight of the two components A and B is about 10-90:90-10.
Claim 3
Dependent Claim
34 words
Mixed crystals as claimed in claim 1, in which the isoelectric point of component A is less than or equal to about 5.5, and that of component B is about 5.8 to about 8.5.
Claim 4
Dependent Claim
44 words
Mixed crystals as claimed in claim 1, wherein component A is human insulin, and component B is selected from the group consisting of Arg-B31 human insulin, Arg 2 -(B31-32) human insulin and a combination of Arg-B31 human insulin and Arg 2 -(B31-32) human insulin.
Claim 5
Dependent Claim
28 words
A pharmaceutical composition containing an effective amount of mixed crystals as claimed in claim 1 for use in the treatment of diabetes mellitus, in a physiologically tolerated vehicle.
Claim 6
Dependent Claim
24 words
A method for treating a patient suffering from diabetes mellitus, which comprises administering to said patient a pharmaceutical composition as claimed in claim 4.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-07-01 | 1994-12-31 | 1995-07-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-07-01 | 1998-12-31 | 1999-07-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-07-01 | 2002-12-31 | 2003-07-02 | $7700.00 | Window Closed / Lapsed |