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Apparatus for measuring and evaluating the inherent fluorescent spectra of organic tissue surfaces

Assignee: Carl Zeiss AG
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Filing: 1989-05-08
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Granted: 1991-05-14
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Expires: 2009-05-08
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Abstract

Abstract The invention relates to a modified microscope-photometer which makes it possible to record and evaluate inherent fluorescent spectra of organic tissue surfaces. The modified microscope-photometer affords the advantage of being able to illuminate the object in a path coaxial to the viewing direction.

Inventors

  • 👤 Jurgen Schwarz
  • 👤 Wolfgang Lohmann

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 19:07
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/62; G01N21/63; G01N21/64; G01N21/645; G01N21/6456; G01N21/6458; A; A61; A61B; A61B3/00; A61B3/10; A61B3/12; A61B3/1241; G01N21/17; G01N21/47; G01N21/4738; G01N21/474; G01N2021/6463; G01N2021/6473; G01N2021/6476

Claims Analysis

Total Claims: 3
Claim 1
Independent Claim 295 words
In an arrangement for measuring and evaluating the inherent fluorescent spectra of the surface of an object defining an object plane, the object being in the form of an organic tissue specimen of a patient, the arrangement including: an evaluation device for determining the maximum intensity of the light reflected from said surface at a wavelength λ A and for determining the maximum intensity of the fluorescent light from said surface in the range of wavelengths longer than λ A ; and, a modified microscope photometer for illuminating the surface of the specimen and for transmitting the light from said surface to said evaluation device, the modified microscope photometer comprising: a housing; a stand for mounting said housing thereon; movable structure means interposed between said stand and said housing for facilitating the movement of said housing with respect to the patient so as to place said housing next to said object; illuminating light source means mounted in said housing for generating light at said wavelength λ A of between 250 nm and 550 nm; imaging means for imaging said light source onto said object to stimulate the inherent fluorescence of the organic tissue of the object; said imaging means including an objective for imaging an object plane and defining an optical axis transverse to said object plane; said objective being capable of transmitting light in the ultra-violet wavelength range and being mounted on said optical axis so as to be movable relative to said object for focussing the reflected and fluorescent light from the latter and transmitting the same down said optical axis; and, a spectrograph operatively connected to said evaluation device and mounted on said optical axis for detecting said light from said object in a wavelength range of 250 nm and 700 nm.
Claim 2
Dependent Claim 295 words
In an arrangement for measuring and evaluating the inherent fluorescent spectra of the surface of an object defining an object plane, the object being in the form of an organic tissue specimen of a patient, the arrangement including: an evaluation device for determining the maximum intensity of the light reflected from said surface at a wavelength λ A and for determining the maximum intensity of the fluorescent light from said surface in the range of wavelengths longer than λ A ; and, a modified microscope photometer for illuminating the surface of the specimen and for transmitting the light from said surface to said evaluation device, the modified microscope photometer comprising: a housing; a stand for mounting said housing thereon; movable structure means interposed between said stand and said housing for facilitating the movement of said housing with respect to the patient so as to place said housing next to said object; illuminating light source means mounted in said housing for generating light at said wavelength λ A of between 250 nm and 550 nm; imaging means for imaging said light source onto said object to stimulate the inherent fluorescence of the organic tissue of the object; said imaging means including an objective for imaging an object plane and defining an optical axis transverse to said object plane; said objective being capable of transmitting light in the ultra-violet wavelength range and being mounted on said optical axis so as to be movable relative to said object for focussing the reflected and fluorescent light from the latter and transmitting the same down said optical axis; and, a spectrograph operatively connected to said evaluation device and mounted on said optical axis for detecting said light from said object in a wavelength range of 250 nm and 700 nm.
Claim 3
Dependent Claim 17 words
The modified microscope photometer of claim 1, comprising a light-conductor shape converter interposed ahead of said spectrograph.

References Cited (Backward Citations)

US4342905A Cited
US4617467A Cited
US4758081A Cited
US4852987A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1994-05-13 1994-11-12 1995-05-14 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1998-05-13 1998-11-12 1999-05-14 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2002-05-13 2002-11-12 2003-05-14 $7700.00 Window Closed / Lapsed

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