US5004803A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Production of procoagulant proteins
Assignee: Genetics Institute LLC
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Filing: 1988-11-14
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Granted: 1991-04-02
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Expires: 2008-11-14
Abstract
Abstract Hybrid procoagulant proteins are disclosed which contain peptide sequences of human blood coagulation factors V and VIII. DNA molecules encoding these proteins and materials and methods for expressing them are also disclosed. Preferably, peptide sequence in the B domain of Factor VIII is replaced with peptide sequence derived from human Factor V.
Inventors
- 👤 Randal J. Kaufman
- 👤 Debra Pittman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 03:25
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/745; C07K14/755; A; A61; A61K; A61K38/00; C07K2319/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
31 words
A DNA encoding a procoagulant-active protein characterized by a peptide sequence of human Factor VIII except within the B domain where it is characterized by peptide sequence of human Factor V.
Claim 2
Dependent Claim
31 words
A DNA encoding a procoagulant-active protein characterized by a peptide sequence of human Factor VIII except within the B domain where it is characterized by peptide sequence of human Factor V.
Claim 3
Dependent Claim
9 words
An expression vector containing a DNA of claim 1.
Claim 4
Dependent Claim
13 words
A host cell containing and capable of expressing a DNA of claim 1.
Claim 5
Dependent Claim
48 words
A method for producing a procoagulant protein which comprises: (a) producing a host cell containing and capable of expressing a DNA of claim 1; (b) culturing the host cell under suitable conditions permitting expression of the DNA; and, (c) recovering the protein so produced from the cell culture.
Claim 6
Dependent Claim
10 words
A procoagulant protein encoded by the DNA of claim 1.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-04-01 | 1994-10-01 | 1995-04-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-04-01 | 1998-10-01 | 1999-04-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-04-01 | 2002-10-01 | 2003-04-02 | $7700.00 | Window Closed / Lapsed |