US5004457A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Tissue transplantation system
Assignee: United States Department of Health and Human Services
•
Filing: 1988-12-02
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Granted: 1991-04-02
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Expires: 2008-12-02
Abstract
Abstract The transplantation of donor tissue into the brain is effected by locking the head relative to a stereotaxic unit; penetrating the brain with a first cannula to a predetermined depth to create a transplant site within the brain while the first cannula is fixed by the stereotaxic unit relative to the brain; then feeding a second cannula, which contains donor tissue at its distal end, through the already fixed first cannula so that the distal end of the second cannula comes to rest at the transplant site; and finally withdrawing the first cannula and the second cannula so as to leave the donor tissue at the transplant site.
Inventors
- 👤 Richard J. Wyatt
- 👤 William J. Freed
- 👤 Richard A. Staub
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:31
CPC Classifications
A; A61; A61B; A61B90/00; A61B90/10; A61B90/11; A61B17/00; A61B17/34; A61B17/3468; A61B2017/00969; A61B90/06; A61B2090/062
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
172 words
A method for transplanting donor tissue into a brain, comprising: providing a first cannula including an open elongated tube having a distal end adapted to penetrate brain tissue; penetrating a brain with the first cannula to a predetermined depth to create a transplant site and fixing said first cannula in space relative to the brain; providing an elongated second cannula having an outer diameter slightly smaller than the inner diameter of said first cannula, and a reducible volumetric portion; filling said reducible volumetric portion of the second cannula with a predetermined quantity of donor tissue to be transplanted; placing the second cannula within the first cannula such that said reducible volumetric portion of the second cannula is located in the vicinity of the transplant site: fixing said second cannula against movement away from said transplant site; axially withdrawing said first cannula in a direction away from said transplant site and along said second cannula; and depositing said donor tissue in said brain at said transplant site, and axially withdrawing said second cannula.
Claim 2
Independent Claim
172 words
A method for transplanting donor tissue into a brain, comprising: providing a first cannula including an open elongated tube having a distal end adapted to penetrate brain tissue; penetrating a brain with the first cannula to a predetermined depth to create a transplant site and fixing said first cannula in space relative to the brain; providing an elongated second cannula having an outer diameter slightly smaller than the inner diameter of said first cannula, and a reducible volumetric portion; filling said reducible volumetric portion of the second cannula with a predetermined quantity of donor tissue to be transplanted; placing the second cannula within the first cannula such that said reducible volumetric portion of the second cannula is located in the vicinity of the transplant site: fixing said second cannula against movement away from said transplant site; axially withdrawing said first cannula in a direction away from said transplant site and along said second cannula; and depositing said donor tissue in said brain at said transplant site, and axially withdrawing said second cannula.
Claim 3
Dependent Claim
54 words
A method according to claim 1 wherein said first cannula further comprises a stylet having a distal end which is slidingly received in said opened elongated tube, and wherein said stylet is withdrawn from said opened elongated tube of said first cannula prior to the placement of the second cannula within the first cannula.
Claim 4
Dependent Claim
68 words
A method according to claim 1 wherein said second cannula comprises a second elongated tube and a second stylet, said reducible volumetric portion constituting a space within the distal end of said second elongated tube below the end of said second stylet, and wherein said depositing of said donor tissue at said transplant site is effected by axially withdrawing said second elongated tube relative to said second stylet.
Claim 5
Dependent Claim
69 words
A method according to claim 1 wherein said depositing of said donor tissue at said transplant site is effected by interaction between said first cannula and second second cannula, whereby a portion of said first cannula coacts with a portion of said second cannula in correspondence with the amount of movement of said first cannula relative to said second cannula to effect reduction in size of said volumetric portion.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-04-01 | 1994-10-01 | 1995-04-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-04-01 | 1998-10-01 | 1999-04-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-04-01 | 2002-10-01 | 2003-04-02 | $7700.00 | Window Closed / Lapsed |