US4997755A
Expired / Lapsed
US
⏱️ 0.0 years remaining
HMG-CoA reductase inhibitors produced by Nocardia sp. (MA 6455)
Assignee: Merck and Co Inc
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Filing: 1988-04-15
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Granted: 1991-03-05
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Expires: 2008-04-15
Abstract
Abstract A microbiological process is described for the preparation of 6-desmethyl-6- beta -hydroxymethyl and 6-desmethyl-6- beta -carboxylovastatin derivatives and 8-acyl analogs thereof.
Inventors
- 👤 Joanne M. Williamson
- 👤 David Houck
- 👤 Edward S. Inamine
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:40
CPC Classifications
C; C07; C07D; C07D309/00; C07D309/16; C07D309/28; C07D309/30; C12; C12N; C12N1/00; C12N1/20; C12N1/205; C12P; C12P17/00; C12P17/02; C12P17/06; C12P7/00; C12P7/62; C12R; C12R2001/00; C12R2001/01; C12R2001/365; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/872
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
67 words
A process for the preparation of a compound represented by the formula (I) ##STR10## wherein: R is CH 2 OH or COOH; which comprises culturing a microorganism Nocardia sp. (MA6455) (ATCC 53695) in a nutrient medium containing assimilable sources of nitrogen and carbon and the sodium salt (II): ##STR11## under aerobic conditions until a substantial amount of the compound is produced and isolating the compound so produced.
Claim 2
Dependent Claim
67 words
A process for the preparation of a compound represented by the formula (I) ##STR10## wherein: R is CH 2 OH or COOH; which comprises culturing a microorganism Nocardia sp. (MA6455) (ATCC 53695) in a nutrient medium containing assimilable sources of nitrogen and carbon and the sodium salt (II): ##STR11## under aerobic conditions until a substantial amount of the compound is produced and isolating the compound so produced.
Claim 3
Dependent Claim
20 words
A process of claim 1 in which the culturing of the microorganism occurs at a temperature of about 27° C.
Claim 4
Dependent Claim
19 words
A process of claim 1 in which the culturing of the microorganism continues from 4 days to 6 days.
Claim 5
Dependent Claim
12 words
A process of claim 3 in which ##STR12## is 2-methylbutyryl or 2,2-dimethylbutyryl.
Claim 6
Dependent Claim
10 words
A process of claim 4 in which ##STR13## is 2,2-dimethylbutyryl.
Claim 7
Dependent Claim
10 words
A process of claim 4 in which ##STR14## is 2-methylbutyryl.
Claim 8
Dependent Claim
12 words
A process of claim 5 in which R is CH 2 OH.
Claim 9
Dependent Claim
10 words
A process of claim 5 in which R is COOH.
Claim 10
Dependent Claim
12 words
A process of claim 6 in which R is CH 2 OH.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-03-04 | 1994-09-03 | 1995-03-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-03-04 | 1998-09-03 | 1999-03-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-03-04 | 2002-09-03 | 2003-03-05 | $7700.00 | Window Closed / Lapsed |