US4980148A
Expired / Lapsed
US
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Methods for enhancing magnetic resonance imaging
Assignee: Mallinckrodt Inc
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Filing: 1985-02-06
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Granted: 1990-12-25
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Expires: 2005-02-06
Abstract
Abstract Substantially nontoxic manganese or gadolinium complexes of compounds of the formula: ##STR1## wherein n and m=1, 2, 3 or 4, y=1, 2 or 3, and x is selected from the group consisting of O, S, CHOH and CHSH, are useful for enhancing magnetic resonance images of body organs and tissues. Illustrative manganese and gadolinium complexes of such compounds include disodium [[ethylenebis(oxyethylenenitrilo)]tetraaceto]-manganese(II), disodium [[(2-hydroxytrimethylene)dinitrilo]-tetraaceto]manganese(II), sodium [[(2-hyroxytrimethylene)dinitrilo]tetraaceto)gadolinium(III).
Inventors
- 👤 Richard T. Dean
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:32
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/06
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
77 words
A method for enhancing magnetic resonance images of body organs and tissues which comprises administering to a mammal a composition comprising a substantially nontoxic manganese or gadolinium complex of a compound of the formula: ##STR4## wherein n and m=1, 2, 3 or 4, y=1, 2 or 3 and X is selected from the group consisting of O, S, CHOH and CHSH, in a sufficient amount to provide enhancement of magnetic resonance images of body organs and tissues.
Claim 2
Independent Claim
77 words
A method for enhancing magnetic resonance images of body organs and tissues which comprises administering to a mammal a composition comprising a substantially nontoxic manganese or gadolinium complex of a compound of the formula: ##STR4## wherein n and m=1, 2, 3 or 4, y=1, 2 or 3 and X is selected from the group consisting of O, S, CHOH and CHSH, in a sufficient amount to provide enhancement of magnetic resonance images of body organs and tissues.
Claim 3
Dependent Claim
24 words
A method for enhancing magnetic resonance images of body organs and tissues as set forth in claim 1 wherein said complex is disodium [[ethylenebis(oxyethylenenitrilo)]tetraaceto]manganese(II).
Claim 4
Dependent Claim
24 words
A method for enhancing magnetic resonance images of body organs and tissues as set forth in claim 1 wherein said complex is disodium [[(2-hydroxytrimethylene)dinitrilo]tetraaceto]manganese(II).
Claim 5
Independent Claim
24 words
A method for enhancing magnetic resonance images of body organs and tissues as set forth in claim, 1 wherein said complex is sodium [[(2-hydroxytrimethylene)dinitrilo]tetraaceto]gadolinium(III).
Claim 6
Dependent Claim
28 words
A method for enhancing magnetic resonance images of body organs and tissues as set forth in claim 1 wherein magnetic resonance images of the hepatobiliary system are enhanced.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-12-24 | 1994-06-25 | 1994-12-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-12-24 | 1998-06-25 | 1998-12-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-12-24 | 2002-06-25 | 2002-12-25 | $7700.00 | Window Closed / Lapsed |