US4958013A
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Cholesteryl modified oligonucleotides
Assignee: Northwestern University
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Filing: 1989-06-06
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Granted: 1990-09-18
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Expires: 2009-06-06
Abstract
Abstract Oligonucleotides modified at their backbones by the attachment of cholesteryl are described. The modified oligonucleotides anchor in the cell membrane to serve as a probe and to provide therapeutic activity.
Inventors
- 👤 Robert L. Letsinger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:11
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; C; C07; C07H; C07H21/00; A61K47/00; A61K47/50; A61K47/51; A61K47/54; A61K47/542; A61K47/554; A61P; A61P31/00; A61P31/12; A61P31/14; A61P31/18; C07J; C07J51/00
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
65 words
An oligonucleotide comprising: ##STR3## wherein A is selected from the group consisting of an aliphatic alkyl, branched aliphatic alkyl, and a heteroatom containing an alkyl chain of 2 to 18 carbon atoms, R is selected from the group consisting of H and lower alkyl up to 12 carbon atoms; NUC is selected from the group consisting of a phosphorothioate oligonucleotide and B is a base.
Claim 2
Dependent Claim
65 words
An oligonucleotide comprising: ##STR3## wherein A is selected from the group consisting of an aliphatic alkyl, branched aliphatic alkyl, and a heteroatom containing an alkyl chain of 2 to 18 carbon atoms, R is selected from the group consisting of H and lower alkyl up to 12 carbon atoms; NUC is selected from the group consisting of a phosphorothioate oligonucleotide and B is a base.
Claim 3
Dependent Claim
16 words
An oligonucleotide as set forth in claim 1 wherein said oligonucleotide includes 7 to 20 nucleotides.
Claim 4
Dependent Claim
13 words
The compound of claim 1 wherein A is CH 2 CH 2 .
References Cited (Backward Citations)
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