US4948540A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of preparing collagen dressing sheet material
Assignee: SECOL COMPANY 100 NORTH MOREHALL ROAD MALVERN PA 19355 A CORP OF PA
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Filing: 1988-08-01
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Granted: 1990-08-14
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Expires: 2008-08-01
Abstract
Abstract A mechanically stable, conformable collagen wound dressing sheet material is fabricated by lyophilizing (freeze-drying) a collagen composition and compressing the porous pad thus produced at a pressure between about 15,000-30,000 p.s.i. The sheet material thus produced may also be treated with optional dehydrothermal crosslinking known in the art. In addition to mechanical stability and conformability, the sheet material demonstrates high absorptivity, i.e., about 15-20 times its weight in isotonic saline, making it highly useful as a medical or surgical dressing or as a carrier for other medicaments such as antibiotics. The sheet material may be impregnated with thrombin.
Inventors
- 👤 Alok Nigam
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 03:43
CPC Classifications
A; A61; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/32; A61L15/325; C; C08; C08J; C08J5/00; C08J5/18; C08J2389/00; C08J2389/04; C08J2389/06; Y; Y10; Y10S; Y10S128/00; Y10S128/08
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
82 words
A method of preparing a collagen dressing sheet, including the steps of: (a) selecting an aqueous composition containing both soluble collagen and native collagen fibers; (b) charging the composition of step (a) to a mold; (c) lyophilizing said composition in said mold to yield a collagen mat having a thickness between 0.2-2 centimeters; (d) compressing said collagen mat at a pressure of between 15,000-30,000 p.s.i. to a thickness of between 0.1-0.5 centimeters; whereby the compressing of said mat imparts high absorptivity thereto.
Claim 2
Independent Claim
82 words
A method of preparing a collagen dressing sheet, including the steps of: (a) selecting an aqueous composition containing both soluble collagen and native collagen fibers; (b) charging the composition of step (a) to a mold; (c) lyophilizing said composition in said mold to yield a collagen mat having a thickness between 0.2-2 centimeters; (d) compressing said collagen mat at a pressure of between 15,000-30,000 p.s.i. to a thickness of between 0.1-0.5 centimeters; whereby the compressing of said mat imparts high absorptivity thereto.
Claim 3
Dependent Claim
25 words
The process according to claim 1 wherein step (a) further comprises the step of: (a) admixing, in aqueous medium, soluble collagen and native collagen fibers.
Claim 4
Dependent Claim
23 words
The process according to claim 2 wherein the mold of step (b) is selected to have base dimensions substantially greater than depth dimensions.
Claim 5
Dependent Claim
50 words
The process according to claim 3 wherein step (c) further comprises the step of: (c) lyophilizing said composition in said mold at a temperature of -60° C. and vacuum of 10 -3 -10 -5 torr for 48 hours with final temperature maintenance at 20° C. for at least 8 hours.
Claim 6
Dependent Claim
39 words
The process according to claim 2 wherein step (a) further comprises the step of: (a) admixing, in aqueous medium, soluble collagen in the amount of 0.5-10% by weight and native collagen fibers in the amount of 0.5-5% by weight.
Claim 7
Dependent Claim
39 words
The process according to claim 2 wherein step (a) further comprises the step of: (a) admixing, in aqueous medium, soluble collagen in the amount of 5.0% by weight and native collagen fibers in the amount of 5.0% by weight.
Claim 8
Dependent Claim
18 words
The process according to claim 6 further comprising the step of: (e) contacting said collagen mat with thrombin.
Claim 9
Dependent Claim
33 words
The process according to claim 7 further comprising the step of: (d) compressing and dehydrothermally crosslinking said collagen mat at a pressure of between 15,000-30,000 p.s.i. to a thickness of between 0.1-0.5 centimeters.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-08-13 | 1994-02-12 | 1994-08-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-08-13 | 1998-02-12 | 1998-08-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-08-13 | 2002-02-12 | 2002-08-14 | $7700.00 | Window Closed / Lapsed |