US4943579A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Water soluble prodrugs of camptothecin
Assignee: United States Department of Health and Human Services
•
Filing: 1987-10-06
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Granted: 1990-07-24
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Expires: 2007-10-06
Abstract
Abstract Water-soluble derivatives of camptothecin have the formulae: <IMAGE> (3) wherein R' is selected from the group consisting of R=CO CH2NH2.HCl R=CO CH2NHCH3.HCl R=CO CH2NHC2H5.HCl R=CO CH2 N(C2H5)2.HCl R=CO CH(NH2) CH2CH2CH2CH2CH2NH2.2HCl R=CO CH(NH2) CH2CH2COOH. HCl R=CO CH2CH2.COO- Na+ R=HPO3- Na+
Inventors
- 👤 B. Rao Vishnuvajjala
- 👤 Aaron Garzon-Aburbeh
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:37
CPC Classifications
C; C07; C07D; C07D491/00; C07D491/22; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/54; A61K47/555
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
80 words
A compound of the formula: ##STR7## wherein R is selected from the group consisting of: R=CO Ch 2 NH 2 .HCl R=CO CH 2 NHCH 3 .HCl R=CO CH 2 NHC 2 H 5 .HCl R=CO CH 2 N(C 2 H 5 ) 2 .HCl R=CO CH(NH 2 ) CH 2 CH 2 CH 2 CH 2 CH 2 NH 2 .2HCl R=CO CH(NH 2 ) CH 2 CH 2 COOH. HCl R=CO CH 2 CH2.COO - Na + .
Claim 2
Dependent Claim
80 words
A compound of the formula: ##STR7## wherein R is selected from the group consisting of: R=CO Ch 2 NH 2 .HCl R=CO CH 2 NHCH 3 .HCl R=CO CH 2 NHC 2 H 5 .HCl R=CO CH 2 N(C 2 H 5 ) 2 .HCl R=CO CH(NH 2 ) CH 2 CH 2 CH 2 CH 2 CH 2 NH 2 .2HCl R=CO CH(NH 2 ) CH 2 CH 2 COOH. HCl R=CO CH 2 CH2.COO - Na + .
Claim 3
Dependent Claim
26 words
A method for administering camptothecin to a patient in need of camptothecin comprising administering to said patient an aqueous solution of a compound of claim 1.
Claim 4
Dependent Claim
45 words
A method of treating cancers which can be treated by administering camptothecin comprising administering to a patient with cancer an aqueous solution of a compound of claim 1 in sufficient quantity to provide from about 5 to about 10.0 mg/kg of body weight of camptothecin.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-07-23 | 1994-01-22 | 1994-07-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-07-23 | 1998-01-22 | 1998-07-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-07-23 | 2002-01-22 | 2002-07-24 | $7700.00 | Window Closed / Lapsed |