US4925268A
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US
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Fiber-optic physiological probes
Assignee: Hospira Inc
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Filing: 1988-07-25
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Granted: 1990-05-15
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Expires: 2008-07-25
Abstract
Abstract Fiber-optic sensors suitable for monitoring physiological analyte concentration. An analyte-permeable matrix is disposed in the light path defined by the axial core at one end of an optical fiber segment. The matrix contains an indicator molecule covalently linked to a polymer, preferably methyl methacrylate/methacrylamidopropyltrimethylammonium chloride, N-vinylpyrrolidone/p-aminostyrene, methyl methacrylate/hydroxymethyl methacrylate, methyl methacrylate/N-vinylpyrrolidone, or methyl methacrylate/acrylic acid. In representative embodiments, the polymer is approximately 94:6 mole/mole percent of either methyl methacrylate/methacrylamidopropyltrimethylammonium chloride or N-vinylpyrrolidone/p-aminostyrene copolymer. Drift-free performance is obtained with such sensors having analyte-permeable matrices of significantly less than about 70 microns in thickness. The indicator molecule may be covalently linked to the polymer through an aminoarylalkylamine, such as 4-(aminophenyl)-ethylamine or 4-(aminophenyl)-propylamine.
Inventors
- 👤 Lokanathan M. Iyer
- 👤 Jeffrey B. Yim
- 👤 Kenneth S. Lyon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:33
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/75; G01N21/77; G01N21/7703; A; A61; A61B; A61B5/00; A61B5/145; A61B5/14539; A61B5/1455; A61B5/1459; G01N21/62; G01N21/63; G01N21/64; G01N21/6428; G01N21/01; G01N21/03; G01N2021/0385; G01N2021/6434; G01N2021/7706; G01N2021/772; G01N2021/7769; G01N2021/7786; G01N21/78; G01N21/783; G01N21/80; G01N21/84; G01N21/85; G01N21/8507
Claims Analysis
Total Claims: 38
Claim 1
Independent Claim
79 words
A fiber-optic sensor suitable for monitoring physiological analyte concentration, comprising an analyte-permeable matrix disposed in the light path defined by the axial core at one end of an optical fiber segment the analyte-permeable matrix comprising an indicator molecule covalently linked to a polymer, the indicator molecule capable of responding to the analyte in an optically detectable manner, and the polymer selected from the group consisting of methyl methacrylate/methacrylamidopropyltrimethylammonium chloride, N-vinylpyrrolidone/p-aminostyrene, methyl methacrylate/hydroxymethyl methacrylate, methyl methacrylate/N-vinylpyrrolidone, and methyl methacrylate/acrylic acid.
Claim 2
Dependent Claim
79 words
A fiber-optic sensor suitable for monitoring physiological analyte concentration, comprising an analyte-permeable matrix disposed in the light path defined by the axial core at one end of an optical fiber segment the analyte-permeable matrix comprising an indicator molecule covalently linked to a polymer, the indicator molecule capable of responding to the analyte in an optically detectable manner, and the polymer selected from the group consisting of methyl methacrylate/methacrylamidopropyltrimethylammonium chloride, N-vinylpyrrolidone/p-aminostyrene, methyl methacrylate/hydroxymethyl methacrylate, methyl methacrylate/N-vinylpyrrolidone, and methyl methacrylate/acrylic acid.
Claim 3
Dependent Claim
23 words
The fiber-optic sensor of claim 1, wherein the polymer is formulated in the range of from about 60:40 to about 80:20 wt/wt percent.
Claim 4
Dependent Claim
22 words
The fiber-optic sensor of claim 1, wherein the polymer comprises approximately 94:6 mole/mole percent of either methyl methacrylate/methacrylamidopropyltrimethylammonium chloride or N-vinylpyrrolidone/p-aminostyrene copolymer.
Claim 5
Dependent Claim
19 words
The fiber-optic sensor of claim 1, wherein the analyte-permeable matrix has a thickness of less than about 70 microns.
Claim 6
Dependent Claim
20 words
The fiber-optic sensor of claim 1, wherein the optical fiber segment has a diameter of approximately 250 microns or less.
Claim 7
Dependent Claim
19 words
The fiber-optic sensor of claim 1, wherein the indicator molecule is covalently linked to the polymer through an aminoarylalkylamine.
Claim 8
Dependent Claim
19 words
The fiber-optic sensor of claim 6, wherein the aminoarylalkylamine is selected from the group consisting of 4-(aminophenyl)-ethylamine and 4-(aminophenyl)-propylamine.
Claim 9
Dependent Claim
18 words
The fiber-optic sensor of claim 7, wherein the indicator molecule is covalently linked to the polymer through 4-(aminophenyl)-ethylamine.
Claim 10
Dependent Claim
14 words
The fiber-optic sensor of claim 1, wherein the indicator molecule is an absorptive molecule.
Claim 11
Dependent Claim
12 words
The fiber-optic sensor of claim 9, wherein the analyte is hydrogen ion.
Claim 12
Dependent Claim
21 words
The fiber-optic sensor of claim 10, wherein the indicator molecule is selected from the group consisting of phenol red and carboxynaphthophthalein.
Claim 13
Dependent Claim
24 words
The fiber-optic sensor of claim 11, wherein the indicator molecule is covalently linked to the polymer through either an azo-amide or an amidyl-amide linkage.
Claim 14
Dependent Claim
14 words
The fiber-optic sensor of claim 1, wherein the indicator molecule is a luminescent molecule.
Claim 15
Dependent Claim
12 words
The fiber-optic sensor of claim 13, wherein the analyte is hydrogen ion.
Claim 16
Dependent Claim
12 words
The fiber-optic sensor of claim 14, wherein the indicator molecule comprises carboxynaphthofluorescein.
Claim 17
Dependent Claim
11 words
The fiber-optic sensor of claim 13, wherein the analyte is oxygen.
Claim 18
Dependent Claim
27 words
The fiber-optic sensor of claim 1, further comprising reflector means disposed in the light path distal with respect to the optical fiber segment to the analyte-permeable matrix.
Claim 19
Dependent Claim
13 words
The fiber-optic sensor of claim 17, wherein the reflector means comprises gold foil.
Claim 20
Dependent Claim
26 words
The fiber-optic sensor of claim 17, wherein the reflector means comprises one or more of the group consisting of titanium dioxide, zinc oxide, and barium sulfate.
Claim 21
Dependent Claim
15 words
The fiber-optic sensor of claim 17, wherein the reflector means is impermeable to the analyte.
Claim 22
Dependent Claim
21 words
The fiber-optic sensor of claim 20, wherein the analyte-permeable membrane has a thickness of from about 15 to about 30 μm.
Claim 23
Dependent Claim
33 words
The fiber-optic sensor of claim 1, further comprising a gas-permeable but ion-impermeable membrane encapsulating the analyte-permeable matrix, the analyte-permeable matrix comprising a base having a pKa ranging from about 6.0 to about 7.8.
Claim 24
Dependent Claim
19 words
The fiber-optic sensor of claim 22, wherein the base has a pKa ranging from about 7.0 to about 7.4.
Claim 25
Dependent Claim
25 words
The fiber-optic sensor of claim 22, wherein the gas-permeable but ion-impermeable membrane comprises a resin selected from the group consisting of silicones, polycarbonates, and urethanes.
Claim 26
Dependent Claim
22 words
The fiber-optic sensor of claim 22, wherein the base comprises an inorganic salt and wherein the analyte-permeable matrix further comprises an antioxidant.
Claim 27
Dependent Claim
13 words
The fiber-optic sensor of claim 26, wherein the inorganic salt comprises a bicarbonate.
Claim 28
Dependent Claim
11 words
The fiber-optic sensor of claim 25, wherein the antioxidant comprises 1,3,5-trimethyl-2,4,6-tris(3,5-di-tert-butyl-4-hydroxybenzyl)benzene.
Claim 29
Dependent Claim
13 words
The fiber-optic sensor of claim 22, wherein the base comprises a polymeric base.
Claim 30
Dependent Claim
27 words
The fiber-optic sensor of claim 28, wherein the polymeric base is selected from the group consisting of monomers, homopolymers, and copolymers of 2-vinylpyridine, 4-vinylpyridine, 1-vinylimidazole, and 4-vinylimidizole.
Claim 31
Dependent Claim
17 words
The fiber-optic sensor of claim 28, wherein the polymeric base is covalently linked to the analyte-permeable matrix.
Claim 32
Dependent Claim
27 words
The fiber-optic sensor of claim 30, wherein the polymeric base is selected from one or more of the group consisting of 2-vinylpyridine, 4-vinylpyridine, histamine, 1-vinylimidazole, and 4-vinylimadazole.
Claim 33
Dependent Claim
25 words
The fiber-optic sensor of claim 22, wherein the analyte-permeable matrix comprises one or more of the group consisting of poly-N-vinylpyrrolidone, polyethylene glycol, and polyethylene oxide.
Claim 34
Dependent Claim
21 words
The fiber-optic sensor of claim 22, wherein the analyte-permeable matrix comprises approximately 80:20 wt/wt percent [(methyl methacrylate/methacrylamidopropyltrimethylammonium chloride) 94:6/polyethylene glycol 600K].
Claim 35
Dependent Claim
20 words
A disposable sensor suitable for monitoring physiological analyte concentration, comprising the fiber-optic sensor of claim 1 in a sterile packet.
Claim 36
Dependent Claim
30 words
A multi-variable probe, comprising a plurality of fiber-optic sensors according to claims 1, 10, 14, 16, or 22, the analyte-permeable matrices of said sensors being disposed in substantially coterminal array.
Claim 37
Dependent Claim
11 words
The multi-variable probe of claim 35, further comprising a thermocouple wire.
Claim 38
Dependent Claim
91 words
The multi-variable probe of claim 35, comprising a pCO 2 sensor according to claim 22 disposed distally to pH and pO 2 sensors in substantially colinear array, the pH sensor according to claims 10 or 14, and the pO 2 sensor comprising an oxygen-permeable matrix disposed in the light path defined by the axial core at one end of an optical fiber segment, the matrix comprising a luminescent indicator molecule admixed with or covalently linked to a polymer, the indicator molecule capable of responding to oxygen in an optically detectable manner.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-05-14 | 1993-11-13 | 1994-05-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-05-14 | 1997-11-13 | 1998-05-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-05-14 | 2001-11-13 | 2002-05-15 | $7700.00 | Window Closed / Lapsed |