US4916207A — Polycarbonate homopolymer-based fiber composition…

Claim 1

Independent Claim 213 words

An implantable medical device fabricated totally or in part from a homopolymer having recurring monomer units of the following General Structure I or II: ##STR10## wherein: ##STR11## combination thereof, where Z is selected such that there are no adjacent heteroatoms; n and m are the same or different and are integers from about 1 to 8; R 1 , R 2 , R 3 and R 4 are the same or different at each occurrence and are hydrogen, aryloxylalkyl, alkoxyaryl, aryloxyaryl, arylalkyl, alkylarylalkyl, arylalkylaryl, alkylaryl, arylcarbonylalkyl, alkyl, aryl, alkylcarbonylalkyl, cycloalkyl, arylcarbonylaryl, alkylcarbonylaryl, alkoxyalkyl, or aryl or alkyl substituted with one or more alkyl, aryl, alkoxy, aryloxy, dialkylamino, diarylamino or alkylarylamino substituents; and R 5 and R 6 are the same or different and are R 1 , R 2 , R 3 , R 4 , dialkylamino, diarylamino, alkylarylamino, alkoxy, aryloxy, alkanoyl, or arylcarbonyl, or any two of R 1 to R 6 together may form an alkylene chain completing a 3, 4, 5, 6, 7, 8 or 9 membered alicyclic fused, spiro, bicyclic, tricylic ring system or a combination thereof, which system may optionally include one or more non-adjacent carbonyl, oxa, alkylaza or arylaza groups; With the proviso that at least one of R 1 to R 6 is other than hydrogen.

Claim 2

Dependent Claim 213 words

An implantable medical device fabricated totally or in part from a homopolymer having recurring monomer units of the following General Structure I or II: ##STR10## wherein: ##STR11## combination thereof, where Z is selected such that there are no adjacent heteroatoms; n and m are the same or different and are integers from about 1 to 8; R 1 , R 2 , R 3 and R 4 are the same or different at each occurrence and are hydrogen, aryloxylalkyl, alkoxyaryl, aryloxyaryl, arylalkyl, alkylarylalkyl, arylalkylaryl, alkylaryl, arylcarbonylalkyl, alkyl, aryl, alkylcarbonylalkyl, cycloalkyl, arylcarbonylaryl, alkylcarbonylaryl, alkoxyalkyl, or aryl or alkyl substituted with one or more alkyl, aryl, alkoxy, aryloxy, dialkylamino, diarylamino or alkylarylamino substituents; and R 5 and R 6 are the same or different and are R 1 , R 2 , R 3 , R 4 , dialkylamino, diarylamino, alkylarylamino, alkoxy, aryloxy, alkanoyl, or arylcarbonyl, or any two of R 1 to R 6 together may form an alkylene chain completing a 3, 4, 5, 6, 7, 8 or 9 membered alicyclic fused, spiro, bicyclic, tricylic ring system or a combination thereof, which system may optionally include one or more non-adjacent carbonyl, oxa, alkylaza or arylaza groups; With the proviso that at least one of R 1 to R 6 is other than hydrogen.

Claim 3

Dependent Claim 14 words

An implantable medical device according to claim 1 which further comprises a biodurable portion.

Claim 4

Dependent Claim 206 words

A fiber comprising a homopolymer having recurring monomer units of the following General Structure I or II: ##STR12## wherein: ##STR13## combination thereof, where Z is selected such that there are no adjacent heteroatoms; n and m are the same or different and are integers from about 1 to 8; R 1 , R 2 , R 3 and R 4 are the same or different at each occurrence and are hydrogen, aryloxyalkyl, alkoxyaryl, aryloxyaryl, arylalkyl, alkylarylalkyl, arylalkylaryl, alkylaryl, arylcarbonylalkyl, alkyl, aryl, alkylcarbonylalkyl, cycloalkyl, arylcarbonylaryl, alkylcarbonylaryl, alkoxyalkyl, or aryl or alkyl substituted with one or more alkyl, aryl, alkoxy, aryloxy, dialkylamino, diarylamino or alkylarylamino substituents; and R 5 and R 6 are the same or different and are R 1 , R 2 , R 3 , R 4 , dialkylamino, diarylamino, alkylarylamino, alkoxy, aryloxy, alkanoyl, or arylcarbonyl, or any two of R 1 to R 6 together may form an alkylene chain completing a 3, 4, 5, 6, 7, 8 or 9 membered alicyclic fused, spiro, bicyclic, tricylic ring system or a combination thereof, which system may optionally include one or more non-adjacent carbonyl, oxa, alkylaza or arylaza groups; With the proviso that at least one of R 1 to R 6 is other than hydrogen.

Claim 5

Dependent Claim 206 words

A fiber comprising a homopolymer having recurring monomer units of the following General Structure I or II: ##STR12## wherein: ##STR13## combination thereof, where Z is selected such that there are no adjacent heteroatoms; n and m are the same or different and are integers from about 1 to 8; R 1 , R 2 , R 3 and R 4 are the same or different at each occurrence and are hydrogen, aryloxyalkyl, alkoxyaryl, aryloxyaryl, arylalkyl, alkylarylalkyl, arylalkylaryl, alkylaryl, arylcarbonylalkyl, alkyl, aryl, alkylcarbonylalkyl, cycloalkyl, arylcarbonylaryl, alkylcarbonylaryl, alkoxyalkyl, or aryl or alkyl substituted with one or more alkyl, aryl, alkoxy, aryloxy, dialkylamino, diarylamino or alkylarylamino substituents; and R 5 and R 6 are the same or different and are R 1 , R 2 , R 3 , R 4 , dialkylamino, diarylamino, alkylarylamino, alkoxy, aryloxy, alkanoyl, or arylcarbonyl, or any two of R 1 to R 6 together may form an alkylene chain completing a 3, 4, 5, 6, 7, 8 or 9 membered alicyclic fused, spiro, bicyclic, tricylic ring system or a combination thereof, which system may optionally include one or more non-adjacent carbonyl, oxa, alkylaza or arylaza groups; With the proviso that at least one of R 1 to R 6 is other than hydrogen.

Claim 6

Dependent Claim 15 words

An implantable medical device fabricated totally or in part from the fiber of claim 3.

Claim 7

Dependent Claim 17 words

A medical device according to claim 4 which is a fabric woven from fibers of claim 3.

Claim 8

Dependent Claim 21 words

A medical device according to claim 4 which is a nerve channel device, tubularly woven from the fiber of claim 26.

Claim 9

Dependent Claim 21 words

A medical device according to claim 4 which is a vascular graft device, tubularly woven from the fiber of claim 3.

Claim 10

Dependent Claim 13 words

A medical device according to claim 4 which further comprises a biodurable portion.

Claim 11

Dependent Claim 54 words

A medical device according to claim 1 wherein R 1 , R 2 , R 3 and R 4 are the same or different and are selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkoxyalkyl, aryloxyalkyl, aryloxyaryl, arylalkyl and aryl and arylalkyl groups substituted with one or more alkyl, alkoxy and alkoxyalkyl groups.

Claim 12

Dependent Claim 48 words

A medical device according to claim 9 wherein R 1 , R 2 , R 3 and R 4 are the same or different and are selected from the groups consisting of hydrogen, alkyl, cycloalkyl, alkoxyalkyl, phenylalkyl and phenyl substituted with one or more alkyl or alkoxy groups.

Claim 13

Dependent Claim 15 words

A medical device according to claim 10 wherein ##STR14## n is 1, 2, or 3.

Claim 14

Dependent Claim 42 words

A medical device according to claim 11 wherein R 1 to R 6 are selected from the group consisting of substituents in which aliphatic moieties include up to about 10 carbon atoms and aryl moieties include up to about 16 carbon atoms.

Claim 15

Dependent Claim 23 words

A medical device according to claim 12 wherein n is 1 or 2 and Z is --[C(R 5 R 6 ) n --].

Claim 16

Dependent Claim 129 words

A medical device according to claim 12 wherein said homopolymer comprises a recurring moiety selected from the group consisting of: ##STR15## wherein: R 5 and R 6 are the same or different and are hydrogen, alkyl, aryl, cycloalkyl, arylalkyl, alkoxyalkyl, aryloxyalkyl, or aryl or arylalkyl substituted with one or more alkyl or alkoxy groups alkoxy, alkanoyl, dialkylamino, or R 5 and R 6 together may form an alkylene chain completing a 4, 5, 6, 7, 8, 9 or 10 membered spiro, bicylic, tricyclic ring structure or a combination thereof, which structure may optionally include one or more non-adjacent divalent carbonyl, oxa, alkylaza or arylaza groups, with the proviso that at least one of R 5 or R 6 is other than hydrogen; and n is 1, 2 or 3.

Claim 17

Dependent Claim 123 words

A medical device according to claim 1 comprising a recurring unit of the formula: ##STR16## wherein: R 1 to R 4 are the same or different and are alkyl, hydrogen, alkoxyalkyl, phenylalkyl or phenyl substituted with one or more alkyl or alkoxy groups, wherein the aliphatic moieties include from about 1 to about 9 carbon atoms; and R 5 and R 6 are the same or different at each occurrence and are selected from the group consisting of R 1 to R 4 substituents, aryloxy and alkoxy, or R 5 and R 6 together form an aliphatic chain completing a 3 to 10 membered ring structure, with the proviso that at least one of R 5 or R 6 is other than hydrogen.

Claim 18

Dependent Claim 93 words

A medical device according to claim 9 wherein; R 5 and R 5 are the same or different and are hydrogen, phenyl, phenylalkyl, phenyl substituted with one or more alkyl or alkoxy groups, or alkyl; or R 5 and R 6 together may form a divalent alkylene chain forming a 3 to 10 membered spiro, bicylic, tricyclic ring structure or a combination thereof, which may optionally include one or more non-adjacent divalent carbonyl or oxa groups, with the proviso that at least one of R 5 and R 6 is other than hydrogen.

Claim 19

Dependent Claim 44 words

A medical device according to claim 16 wherein R 5 and R 6 are the same or different and are phenyl, phenylalkyl, alkylphenyl, alkyl, or R 5 and R 6 together form alkylene a divalent chain forming a 4 to 8 membered ring structure.

Claim 20

Dependent Claim 31 words

A medical device according to claim 17 wherein R 5 and R 6 together form a divalent alkylene chain forming a 4 to 8 membered spiro, bicyclic and/or tricyclic ring structure.

Claim 21

Dependent Claim 29 words

A medical device according to claim 18 wherein R 5 and R 6 together form a 5 to 7 membered spiro, bicylic or a spiro and bicylic ring structure.

Claim 22

Dependent Claim 16 words

A medical device according to claim 17 wherein R 5 and R 6 are the same.

Claim 23

Dependent Claim 25 words

A medical device according to claim 17 wherein R 5 and R 6 are the same or different and are alkyl, phenyl, alkylphenyl or phenylalkyl.

Claim 24

Dependent Claim 21 words

A medical device according to claim 17 wherein R 5 and R 6 are the same or different and are alkyl.

Claim 25

Dependent Claim 30 words

A medical device according to claim 22 wherein R 5 and R 6 are the same or different and are lower alkyl of from about 1 to 7 carbon atoms.

Claim 26

Dependent Claim 40 words

A medical device according to claim 23 wherein R 5 and R 6 are the same or different and are selected from the group consisting of methyl, ethyl, propyl, isopropyl, n-butyl, tertiary butyl, pentyl, neopentyl, hexyl and a secondary butyl.

Claim 27

Dependent Claim 26 words

A medical device according to claim 22 wherein R 5 and R 6 do not differ from each other by more than about 3 carbon atoms.

Claim 28

Dependent Claim 26 words

A medical device according to claim 24 wherein R 5 and R 6 do not differ from each other by more than about 2 carbon atoms.

Claim 29

Dependent Claim 22 words

A medical device according to claim 26 wherein R 5 and R 6 are alkyl of about 1 to 4 carbon atoms.

Claim 30

Dependent Claim 22 words

A medical device according to claim 27 wherein R 5 and R 6 are alkyl of about 1 to 2 carbon atoms.

Claim 31

Dependent Claim 19 words

A medical device according to claim 27 wherein R 5 and R 6 are the same and are methyl.

Claim 32

Dependent Claim 16 words

A medical device according to claim 22 wherein R 5 and R 6 are the same.

Claim 33

Dependent Claim 53 words

The fiber according to claim 3 wherein R 1 , R 2 , R 3 and R 4 are the same or different and are selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkoxyalkyl, aryloxyalkyl, aryloxyaryl, arylalkyl and aryl and arylalkyl groups substituted with one or more alkyl, alkoxy and alkoxyalkyl groups.

Claim 34

Dependent Claim 47 words

The fiber according to claim 30 wherein R 1 , R 2 , R 3 and R 4 are the same or different and are selected from the groups consisting of hydrogen, alkyl, cycloalkyl, alkoxyalkyl, phenylalkyl, and phenyl substituted with one or more alkyl or alkoxy groups.

Claim 35

Dependent Claim 13 words

The fiber of claim 31 wherein: ##STR17## n is 1, 2 or 3.

Claim 36

Dependent Claim 128 words

The fiber according to claim 32 wherein the homopolymer comprises a recurring moiety selected from the group consisting of: ##STR18## wherein: R 5 and R 6 are the same or different and are hydrogen, alkyl, aryl, cycloalkyl, arylalkyl, alkoxyalkyl, aryloxyalkyl, or aryl or arylalkyl substituted with one or more alkyl or alkoxy groups alkoxy, alkanoyl, dialkylamino, or R 5 and R 6 together may form an alkylene chain completing a 4, 5, 6, 7, 8, 9 or 10 membered spiro, bicyclic, tricyclic ring structure or a combination thereof, which structure may optionally include one or more non-adjacent divalent carbonyl, oxa, alkylaza or arylaza groups, with the proviso that at least one of R 5 or R 6 is other than hydrogen; and n is 1, 2 or 3.

Claim 37

Dependent Claim 125 words

The fiber according to claim 3 wherein said homopolymer comprises a recurring unit of the formula: ##STR19## wherein: R 1 to R 4 are the same or different and are alkyl, hydrogen, alkoxyalkyl, phenylalkyl, or phenyl substituted with one or more alkyl or alkoxy groups, wherein the aliphatic moieties include from abut 1 to about 9 carbon atoms; and R 5 and R 6 are the same or different at each occurrence and are selected from the group consisting of R 1 to R 4 substituents, aryloxy, and alkoxy, or R 5 and R 6 together form an aliphatic chain completing a 3 to 10 membered ring structure, with the proviso that at least one of R 5 or R 6 is other than hydrogen.

Claim 38

Dependent Claim 91 words

The fiber according to claim 33 wherein: R 5 and R 6 are the same or different and are hydrogen, phenyl, phenylalkyl, phenyl substituted with one or more alkyl or alkoxy groups, or alkyl; or R 5 and R 6 together may form a divalent alkylene chain forming a 3 to 10 membered spiro, bicyclic, tricyclic ring structure or combination thereof which may optionally include one or more non-adjacent divalent carbonyl or oxa groups, with the proviso that at least one of R 5 and R 6 is other than hydrogen.

Claim 39

Dependent Claim 43 words

A fiber according to claim 35 wherein R 5 and R 6 are the same or different and are phenyl, phenylalkyl, alkylphenyl, alkyl, or R 5 and R 6 together form alkylene a divalent chain forming a 4 to 8 embered ring structure.

Claim 40

Dependent Claim 15 words

The fiber according to claim 36 wherein R 5 and R 6 are the same.

Claim 41

Dependent Claim 24 words

The fiber according to claim 37 wherein R 5 and R 6 are the same or different and are alkyl, phenyl, alkylphenyl or phenylalkyl.

Claim 42

Dependent Claim 20 words

The fiber according to claim 38 wherein R 5 and R 6 are the same or different and are alkyl.

Claim 43

Dependent Claim 29 words

The fiber according to claim 39 wherein R 5 and R 6 are the same or different and are lower alkyl of from about 1 to 7 carbon atoms.

Claim 44

Dependent Claim 21 words

The fiber according to claim 40 wherein R 5 and R 6 are alkyl of about 1 to 4 carbon atoms.

Claim 45

Dependent Claim 18 words

The fiber according to claim 41 wherein R 5 and R 6 are the same and are methyl.

Claim 46

Dependent Claim 15 words

The fiber according to claim 35 wherein R 5 and R 6 are the same.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1993-04-09	1993-10-09	1994-04-10	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1997-04-09	1997-10-09	1998-04-10	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2001-04-09	2001-10-09	2002-04-10	$7700.00	Window Closed / Lapsed

Polycarbonate homopolymer-based fiber compositions and method of melt-spinning same and device

Abstract

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