US4916073A
Expired / Lapsed
US
⏱️ 0.0 years remaining
CDNA and gene for human angiogenin (angiogenesis factor) and methods of expression
Assignee: Harvard University
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Filing: 1988-12-01
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Granted: 1990-04-10
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Expires: 2008-12-01
Abstract
Abstract DNA sequences encoding a protein having angiogenic activity are disclosed. Expression vectors containing these sequences are introduced into host cells and direct the production of the angiogenic protein. Proteins produced according to the invention are useful in the diagnosis of malignancies, for promoting wound healing, and for other diagnostic and therapeutic purposes.
Inventors
- 👤 Bert L. Vallee
- 👤 Kotoku Kurachi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:10
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/475; C07K14/515; A; A61; A61P; A61P17/00; A61P43/00; A61K; A61K38/00
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
60 words
A vector for expressing in transformed bacteria the protein defined in FIG. 1 or a protein having substantially the same amino acid sequence and substantially the same angiogenic activity as the protein of FIG. 1, said vector includes a DNA construct comprising the DNA sequence coding for said protein and a promoter upstream of and operably linked to said sequence.
Claim 2
Dependent Claim
60 words
A vector for expressing in transformed bacteria the protein defined in FIG. 1 or a protein having substantially the same amino acid sequence and substantially the same angiogenic activity as the protein of FIG. 1, said vector includes a DNA construct comprising the DNA sequence coding for said protein and a promoter upstream of and operably linked to said sequence.
Claim 3
Dependent Claim
10 words
A bacterial cell transformed with the vector of claim 1.
References Cited (Backward Citations)
US4721672A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-04-09 | 1993-10-09 | 1994-04-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-04-09 | 1997-10-09 | 1998-04-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-04-09 | 2001-10-09 | 2002-04-10 | $7700.00 | Window Closed / Lapsed |