Patent US4666442A successfully refreshed from Google Patents.
US4902286A
Expired / Lapsed
US
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Container for fertilization of human ovocytes in the absence of CO2 -enriched air
Assignee: Medelle Corp
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Filing: 1986-11-07
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Granted: 1990-02-20
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Expires: 2006-11-07
Abstract
Abstract The invention relates to a container for fertilization of human ovocytes in the absence of CO 2 which may be done in an incubuator at 37° C. or in the vaginal cavity. The container of cylindrical shape has smooth and rounded walls 1 whose thickness is 2 mm in the body 2 of the cylinder but only 1 mm at the neck 3. On the outer wall of the neck is seen a screwthread 4 permitting external screwing on of the plug 12 whose sides are smooth and rounded. The blind end 5 of the container is rounded, the other 6 is flat and has a round orifice 7, which orifice is closed by a fine membrane 9 permitting hermeticity of the tube in order to avoid disorders of the culture medium 8 present in the container as of manufacture. Above the liquid remains about 200 μl of gas 10. The inner walls 11 are smooth and rounded. After depositing the ovocytes and spermatozoa necessary for fertilization, and therefore after rupture of the membrane, hermeticity will be effected by two seals, after screwing on the plug, a circular one 13 at the neck of the tube, the other 14 on the endwall of the plug which will be flattened against the orifice of the tube 7 by a relief portion, located on the endwall of the plug 15, whose diameter is substantially that of the orifice. The container will be held in the posterior fornix of the vaginal cavity by a flexible ring comprised of a metal strip 17 sheathed in rubber 18 to which is fixed a rubber pouch 19 in which the container is placed. This device thus permits inter-vaginal, fertilization of human ovocytes in the absence of CO 2 -enriched air, the vaginal cavity replacing the incubator conventionally used.
Inventors
- 👤 Claude Ranoux
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:41
CPC Classifications
A; A61; A61B; A61B17/00; A61B17/42; A61B17/425; A61B17/435; A61B50/00
Claims Analysis
Total Claims: 34
Claim 1
Independent Claim
171 words
A container for in-vitro fertilization of ovocytes and intravaginal culture, said container being of a size and configuration suitable for accommodation in a human vagina, said container comprising a hollow body containing a culture medium suitable for use in fertilization and culture of human ovocytes and having an orifice, said hollow body having rounded inner walls that are smooth over their entire extent, rupturable sealing means closing said orifice and hermetically sealing off the interior of the hollow body containing culture medium, said rupturable sealing means when ruptured permitting the introduction of ovocytes and spermatozoa into the container body, and a closure means cooperable with the container body and adapted to overlie the orifice, and resealing means operatively disposed between the container body and the closure means for hermetically resealing the container after rupture of the rupturable sealing means and introduction of ovocytes and spermatozoa to permit in-vitro fertilization of the ovocytes and intravaginal culture, the container when hermetically resealed having rounded outer walls that are smooth over their entire extent.
Claim 2
Dependent Claim
171 words
A container for in-vitro fertilization of ovocytes and intravaginal culture, said container being of a size and configuration suitable for accommodation in a human vagina, said container comprising a hollow body containing a culture medium suitable for use in fertilization and culture of human ovocytes and having an orifice, said hollow body having rounded inner walls that are smooth over their entire extent, rupturable sealing means closing said orifice and hermetically sealing off the interior of the hollow body containing culture medium, said rupturable sealing means when ruptured permitting the introduction of ovocytes and spermatozoa into the container body, and a closure means cooperable with the container body and adapted to overlie the orifice, and resealing means operatively disposed between the container body and the closure means for hermetically resealing the container after rupture of the rupturable sealing means and introduction of ovocytes and spermatozoa to permit in-vitro fertilization of the ovocytes and intravaginal culture, the container when hermetically resealed having rounded outer walls that are smooth over their entire extent.
Claim 3
Dependent Claim
17 words
A container according to claim 1, wherein said rupturable sealing means comprises a membrane covering said orifice.
Claim 4
Dependent Claim
25 words
A container according to claim 1, wherein internal threads are provided on the closure means and complementary external threads are provided on the container body.
Claim 5
Dependent Claim
31 words
A container according to claim 3, wherein said container body has a neck proximate an end of said container body adjacent said orifice, said external threads being defined on said neck.
Claim 6
Dependent Claim
26 words
A container according to claim 4, wherein said closure means comprises a plug having a depending side-wall, said internal threads being formed on said depending sidewall.
Claim 7
Dependent Claim
20 words
A container according to claim 5, said plug being of the same diameter as the body immediately beyond said neck.
Claim 8
Dependent Claim
61 words
A container according to claim 1, wherein a relief portion is formed on the underside of the closure means and has a diameter substantially equal to that of the orifice, said resealing means comprising a seal lining the underside of the closure means including said relief portion and being sealingly engageable with an endwall of the container body adjacent the orifice.
Claim 9
Dependent Claim
59 words
A container according to claim 5, wherein a relief portion is formed on the underside of the plug and has a diameter substantially equal to that of the orifice, and said resealing means comprises a seal lining the underside of the plug including said relief portion and is seal-ingly engageable with the endwall of the body adjacent the orifice.
Claim 10
Dependent Claim
43 words
A container according to claim 5, wherein said sidewall has a free edge, said container body having an annular shoulder beyond said external screwthreads relative to said orifice, said resealing means comprising an annular seal between said free edge and said annular shoulder.
Claim 11
Dependent Claim
43 words
A container according to claim 6, wherein said sidewall has a free edge, said container body having an annular shoulder beyond said external screwthreads relative to said orifice, said resealing means comprising an annular seal between said free edge and said annular shoulder.
Claim 12
Dependent Claim
20 words
A container according to claim 1, in combination with a holding device for maintaining the container in a posterior fornix.
Claim 13
Dependent Claim
24 words
A container according to claim 1, wherein the container has an effective volume of about 3.2 cm 3 to about 5 cm 3 .
Claim 14
Dependent Claim
24 words
A container according to claim 1, wherein the container is approximately 4 to 4.5 cm long and approximately 1.5 to 1.7 cm in diameter.
Claim 15
Dependent Claim
49 words
A container according to claim 1, wherein the diameter of the orifice of the container is less than half that of the container at its end adjacent said orifice to minimize communication between the interior of the container and the surroundings when the ovocytes and spermatozoa are being introduced.
Claim 16
Dependent Claim
15 words
A container according to claim 1, wherein the internal cavity of the container is oval.
Claim 17
Dependent Claim
20 words
A container according to claim 1, wherein the end of the container remote from the orifice has a rounded surface.
Claim 18
Dependent Claim
19 words
A container according to claim 1, wherein the culture medium substantially entirely fills the internal cavity of the container.
Claim 19
Dependent Claim
30 words
A container according to claim 1, wherein the internal cavity has a volume of about 3.2 to 5 cm 3 and there is an empty space of about 200 μl.
Claim 20
Dependent Claim
141 words
Apparatus for in-vitro fertilization of ovocytes and intravaginal culture, comprising an intravaginal container of a size and configuration suitable for accommodation in a vagina, said container comprising a hollow body containing a culture medium suitable for use in fertilization and culture of ovocytes, said hollow body having rounded inner walls that are smooth over their entire extent, a closure means for hermetically sealing the container body, a wall portion of the container body being rupturable, the closure means being adapted to overlie the rupturable wall portion after rupture, and means for penetrating said rupturable wall portion to introduce ovocytes and spermatozoa into the container body containing the culture medium so as to permit in-vitro fertilization and intravaginal culture in the hermetically sealed container, the hermetically sealed container during said culture having rounded outer walls that are smooth over their entire extent.
Claim 21
Dependent Claim
141 words
Apparatus for in-vitro fertilization of ovocytes and intravaginal culture, comprising an intravaginal container of a size and configuration suitable for accommodation in a vagina, said container comprising a hollow body containing a culture medium suitable for use in fertilization and culture of ovocytes, said hollow body having rounded inner walls that are smooth over their entire extent, a closure means for hermetically sealing the container body, a wall portion of the container body being rupturable, the closure means being adapted to overlie the rupturable wall portion after rupture, and means for penetrating said rupturable wall portion to introduce ovocytes and spermatozoa into the container body containing the culture medium so as to permit in-vitro fertilization and intravaginal culture in the hermetically sealed container, the hermetically sealed container during said culture having rounded outer walls that are smooth over their entire extent.
Claim 22
Dependent Claim
31 words
Apparatus according to claim 19, wherein said rupturable wall portion is a membrane for initially closing off an orifice of the internal cavity of the container body containing the culture medium.
Claim 23
Dependent Claim
24 words
Apparatus according to claim 19, wherein internal threads are provided on the closure means and complementary external threads are provided on the container body.
Claim 24
Dependent Claim
32 words
Apparatus according to claim 21, wherein said container body has a neck proximate an end of said container body adjacent said rupturable wall portion, said external threads being defined on said neck.
Claim 25
Dependent Claim
25 words
Apparatus according to claim 22, wherein said closure means comprises a plug having a depending sidewall, said internal threads being formed on said depending sidewall.
Claim 26
Dependent Claim
19 words
Apparatus according to claim 23, said plug being substantially of the same diameter as the body beyond said neck.
Claim 27
Dependent Claim
57 words
Apparatus according to claim 23, wherein a relief portion is formed on the underside of the plug and has a diameter substantially equal to that of the orifice, and a seal that lines the underside of the plug including said relief portion and is sealingly engageable with the endwall of the body adjacent the rupturable wall portion.
Claim 28
Dependent Claim
42 words
Apparatus according to claim 23, wherein said sidewall has a free edge, said container body having an annular shoulder beyond said external screwthreads relative to said rupturable wall portion, an annular seal being disposed between said free edge and said annular shoulder.
Claim 29
Dependent Claim
28 words
Apparatus according to claim 19, wherein the rupturable wall portion is less than one-half the diameter of an endwall of the container body adjacent the rupturable wall portion.
Claim 30
Dependent Claim
21 words
Apparatus according to claim 19, further comprising a holding device for maintaining the container in the posterior fornix of the vagina.
Claim 31
Dependent Claim
191 words
A container for in-vitro fertilization of ovocytes and intravaginal culture, said container being of a size and configuration suitable for accommodation in a human vagina, said container comprising a hollow body containing a culture medium suitable for use in fertilization and culture of human ovocytes and having an orifice, said hollow body having rounded inner walls that are smooth over their entire extent, rupturable sealing means closing said orifice and hermetically sealing off the interior of the hollow body containing culture medium, said rupturable sealing means when ruptured permitting the introduction of ovocytes and spermatozoa into the container body, and a closure means cooperable with the container body and adapted to overlie the orifice, and resealing means operatively disposed between the container body and the closure means for hermetically resealing the container after rupture of the rupturable sealing means and introduction of ovocytes and spermatozoa to permit in-vitro fertilization of the ovocytes and intravaginal culture, in combination with a holding device for maintaining the container in a posterior fornix, said holding device comprising a ring and a flexible pouch for receiving the container, said flexible pouch being attached to the ring.
Claim 32
Dependent Claim
191 words
A container for in-vitro fertilization of ovocytes and intravaginal culture, said container being of a size and configuration suitable for accommodation in a human vagina, said container comprising a hollow body containing a culture medium suitable for use in fertilization and culture of human ovocytes and having an orifice, said hollow body having rounded inner walls that are smooth over their entire extent, rupturable sealing means closing said orifice and hermetically sealing off the interior of the hollow body containing culture medium, said rupturable sealing means when ruptured permitting the introduction of ovocytes and spermatozoa into the container body, and a closure means cooperable with the container body and adapted to overlie the orifice, and resealing means operatively disposed between the container body and the closure means for hermetically resealing the container after rupture of the rupturable sealing means and introduction of ovocytes and spermatozoa to permit in-vitro fertilization of the ovocytes and intravaginal culture, in combination with a holding device for maintaining the container in a posterior fornix, said holding device comprising a ring and a flexible pouch for receiving the container, said flexible pouch being attached to the ring.
Claim 33
Dependent Claim
159 words
Apparatus for in-vitro fertilization of ovocytes and intravaginal culture, comprising an intravaginal container of a size and configuration suitable for accommodation in a vagina, said container comprising a hollow body containing a culture medium suitable for use in fertilization and culture of ovocytes, said hollow body having rounded inner walls that are smooth over their entire extent, a closure means for hermetically sealing the container body, a wall portion of the container body being rupturable, the closure means being adapted to overlie the rupturable wall portion after rupture, and means for penetrating said rupturable wall portion to introduce ovocytes and spermatozoa into the container body containing the culture medium so as to permit in-vitro fertilization and intravaginal culture in the hermetically sealed container, in combination with a holding device for maintaining the container in a posterior fornix, said holding device comprising a ring and a flexible pouch for receiving the container, said flexible pouch being attached to the ring.
Claim 34
Dependent Claim
159 words
Apparatus for in-vitro fertilization of ovocytes and intravaginal culture, comprising an intravaginal container of a size and configuration suitable for accommodation in a vagina, said container comprising a hollow body containing a culture medium suitable for use in fertilization and culture of ovocytes, said hollow body having rounded inner walls that are smooth over their entire extent, a closure means for hermetically sealing the container body, a wall portion of the container body being rupturable, the closure means being adapted to overlie the rupturable wall portion after rupture, and means for penetrating said rupturable wall portion to introduce ovocytes and spermatozoa into the container body containing the culture medium so as to permit in-vitro fertilization and intravaginal culture in the hermetically sealed container, in combination with a holding device for maintaining the container in a posterior fornix, said holding device comprising a ring and a flexible pouch for receiving the container, said flexible pouch being attached to the ring.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-02-19 | 1993-08-21 | 1994-02-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-02-19 | 1997-08-21 | 1998-02-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-02-19 | 2001-08-21 | 2002-02-20 | $7700.00 | Window Closed / Lapsed |