Patent JPS57120519A successfully refreshed from Google Patents.
US4895724A
Expired / Lapsed
US
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Chitosan compositions for controlled and prolonged release of macromolecules
Assignee: Pfizer Inc
•
Filing: 1985-06-07
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Granted: 1990-01-23
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Expires: 2005-06-07
Abstract
Abstract Compositions for the controlled and prolonged release of macromolecular compounds comprise a porous matrix of chitosan having dispersed therein the macromolecular compound. Examples of macromolecules used in the composition are pharmacologically active ones such as peptide hormones, e.g. growth hormone.
Inventors
- 👤 John R. Cardinal
- 👤 William J. Curatolo
- 👤 Charles D. Ebert
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:06
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1652; A61K9/20; A61K9/2004; A61K9/2022; A61K9/205
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
44 words
A composition for controlled and prolonged release of at least one macromoleculor compound which composition comprises a porous mix of chitosan having dispersed therein said macromolecular compound, and which composition has been contacted with at least one of an organic solvent or a base.
Claim 2
Dependent Claim
44 words
A composition for controlled and prolonged release of at least one macromoleculor compound which composition comprises a porous mix of chitosan having dispersed therein said macromolecular compound, and which composition has been contacted with at least one of an organic solvent or a base.
Claim 3
Dependent Claim
13 words
A composition according to claim 1 wherein said composition is injectable or implantable
Claim 4
Dependent Claim
13 words
A composition according to claim 1 wherein said macromolecular compound is pharmacologically active.
Claim 5
Dependent Claim
20 words
A composition according to claim 1 wherein said macromolecular compound is selected from the group consisting of proteins and polypeptide.
Claim 6
Dependent Claim
20 words
A composition according to claim 1 wherein said macromolecular compound is selected from the group consisting of hormones and enzymes.
Claim 7
Dependent Claim
13 words
A composition according to claim 5 wherein said hormone is bovine growth hormone.
Claim 8
Dependent Claim
16 words
A composition according to claim 1 wherein said macromolecular compound is an antigen of biological origin.
Claim 9
Dependent Claim
13 words
A composition according to claim 1 wherein said organic solvent is an alcohol.
Claim 10
Dependent Claim
12 words
A composition according to claim 1 wherein said organic solvent is methanol.
Claim 11
Dependent Claim
15 words
A composition according to claim 1 wherein said composition is in the form of particles.
Claim 12
Dependent Claim
22 words
A composition according to claim 1 wherein said macromolecular compound is present in an amount of 5 to 50 percent by weight.
Claim 13
Dependent Claim
21 words
A composition according to claim 1 wherein said chitosan is derived from chitin which has been about 90 to 90% deacetylated.
Claim 14
Dependent Claim
19 words
A composition according to claim 12 wherein said chitosan has a molecular weight ranging from 100,000 to two million.
Claim 15
Dependent Claim
26 words
A composition for controlled and prolonged release of a macromolecular compound which composition comprises a porous matrix of crosslinked chitosan having dispersed therein said macromolecular compound.
Claim 16
Dependent Claim
26 words
A composition for controlled and prolonged release of a macromolecular compound which composition comprises a porous matrix of crosslinked chitosan having dispersed therein said macromolecular compound.
Claim 17
Dependent Claim
30 words
A composition according to claim 14 wherein said chitosan is cross-linked with a cross-linking agent selected from the group consisting of glutaraldehyde, glyoxal, epichlorohydrin, succinaldehyde, 1,10-decandeial, trichlorotriazine, benzoquinone, and bisepoxiranes.
Claim 18
Dependent Claim
19 words
A composition according to claim 14 wherein said chitosan is a cross-linked at the surface of said porous matrix.
Claim 19
Dependent Claim
21 words
A composition according to claim 16 wherein said surface cross-linking is with a macromolecular compound containing more than one aldehyde group.
Claim 20
Dependent Claim
20 words
A composition according to claim 17 wherein said macromolecular compound containing more than one aldehyde group is an oxidized polysaccharide.
Claim 21
Dependent Claim
22 words
A composition according to claim 18 wherein said oxidized polysaccharide is selected from the group consisting of starch dialdehyde and dextran dialdehyde.
Claim 22
Independent Claim
31 words
A method of administering a pharmacologically active macromolecular compound which comprises injecting or implanting in a subject in need of treatment a porous chitosan matrix having said macromolecular compound dispersed therein.
Claim 23
Independent Claim
31 words
A method of administering a pharmacologically active macromolecular compound which comprises injecting or implanting in a subject in need of treatment a porous chitosan matrix having said macromolecular compound dispersed therein.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-01-22 | 1993-07-24 | 1994-01-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-01-22 | 1997-07-24 | 1998-01-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-01-22 | 2001-07-24 | 2002-01-23 | $7700.00 | Window Closed / Lapsed |