Intermediates and processes for β-6-hydroxymethyl HMG-CoA reductable inhibitors

Claim 1

A compound of structural formula (9): ##STR29## wherein: n is 0 to 3; R 1 and R 2 independently are hydrogen, C 1-5 alkyl, or R 1 and R 2 together with the carbon atom to which they are attached form a carbocyclic ring of 3 to 8 carbon atoms; R 3 and R 4 are independently hydrogen, C 1-3 alkyl, C 3-7 cycloalkyl, C 1-3 alkylthio, phenyl, phenylthio or substituted phenyl in which the substituents are V and W and when n is 2 to 3, each of the R 3 s and R 4 s are independently hydrogen. C 1-3 alkyl, C 3-7 cycloalkyl or only one of the R.sub. s and R 4 s is phenyl or substituted phenyl; R 5 is hydrogen, tosylate, OT, C 1-5 alkyl or C 1-5 alkyl substituted with tosylate or OT, or C 3-7 cycloalkyl or C 3-7 -cycloalkyl substituted with C 1-3 alkyl, tosylate, or OT, C 2-5 alkenyl, phenyl or substituted phenyl in which the substituents are V and W, or R 5 is a group selected from: (a) C 1-5 -alkanoyloxy-C 1-4 -alkyl, (b) ##STR30## in which m is 0 to 3 and R 6 is C 1-5 alkyl; (c) ##STR31## in which R 7 and R 8 are independently C 1-5 alkyl or R 7 and R 8 together with the nitrogen atom to which they are attached form a heterocycle selected from piperidinyl, morpholinyl, pyrrolidinyl, piperazinyl or thiomorpholinyl; (d) ##STR32## in which q is 0 to 2 and R 9 is C 1-5 alkyl or phenyl or substituted phenyl in which the substituents are V and W; V and W independently are hydrogen, halogen, hydroxy, trifluoromethyl, C 1-3 alkyl, C 1-3 alkyloxy and TO-C 1-3 alkyl; T is tert-butyldimethylsilyl, tert-butyldiphenylsilyl, trimethylsilyl, triethylsilyl, triisopropylsilyl or tetrahydropyranyl.