US4889634A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dialysate solution containing hydroxypropyl-beta-cyclodextrin and method of using same
Assignee: Gynex Pharmaceuticals Inc
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Filing: 1988-10-04
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Granted: 1989-12-26
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Expires: 2008-10-04
Abstract
Abstract A dialysate solution suitable for peritoneal dialysis and containing hydroxypropyl-beta-cyclodextrin is disclosed.
Inventors
- 👤 Ragab El-Rashidy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 08:33
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/14; A61M1/28; A61M1/287
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
95 words
An aqueous composition suitable for peritoneal dialysis and comprising: hydroxypropyl-beta-cyclodextrin in an amount in the range of about 5 to about 35 g/dl; sodium in an amount in the range of about 110 to about 150 mEq/l; potassium in an amount in the range of about 0 to about 5 mEq/l; calcium in an amount in the range of about 0 to about 6 mEq/l; magnesium in an amount in the range of about 0 to about 4 mEq/l; and alkali equivalent in an amount in the range of about 35 to about 40 mEq/l.
Claim 2
Dependent Claim
95 words
An aqueous composition suitable for peritoneal dialysis and comprising: hydroxypropyl-beta-cyclodextrin in an amount in the range of about 5 to about 35 g/dl; sodium in an amount in the range of about 110 to about 150 mEq/l; potassium in an amount in the range of about 0 to about 5 mEq/l; calcium in an amount in the range of about 0 to about 6 mEq/l; magnesium in an amount in the range of about 0 to about 4 mEq/l; and alkali equivalent in an amount in the range of about 35 to about 40 mEq/l.
Claim 3
Dependent Claim
38 words
The aqueous composition in accordance with claim 1 wherein the hydroxypropyl-beta-cyclodextrin has a degree of substitution of about 5 to about 7 and is present in an amount in the range of about 7.5 to about 25 g/dl.
Claim 4
Independent Claim
153 words
A method for peritoneal dialysis which comprises the steps of: providing an aqueous dialysate containing: hydroxypropyl-beta-cyclodextrin in an amount in the range of about 5 to about 35 g/dl; sodium in an amount in the range of about 110 to about 150 mEq/l; potassium in an amount in the range of about 0 to about 5 mEq/l; calcium in an amount in the range of about 0 to about 6 mEq/l; magnesium in an amount in the range of about 0 to about 4 mEq/l; and alkali equivalent in an amount in the range of about 35 to about 40 mEq/l. introducing an aliquot of said dialysate into the peritoneal cavity of a patient in need of dialysis; maintaining the introduced dialysate in the peritoneal cavity for a time period sufficient for toxins present to enter the dialysate; and thereafter removing from the peritoneal cavity a dialysate aliquot having an increased toxin content.
Claim 5
Independent Claim
153 words
A method for peritoneal dialysis which comprises the steps of: providing an aqueous dialysate containing: hydroxypropyl-beta-cyclodextrin in an amount in the range of about 5 to about 35 g/dl; sodium in an amount in the range of about 110 to about 150 mEq/l; potassium in an amount in the range of about 0 to about 5 mEq/l; calcium in an amount in the range of about 0 to about 6 mEq/l; magnesium in an amount in the range of about 0 to about 4 mEq/l; and alkali equivalent in an amount in the range of about 35 to about 40 mEq/l. introducing an aliquot of said dialysate into the peritoneal cavity of a patient in need of dialysis; maintaining the introduced dialysate in the peritoneal cavity for a time period sufficient for toxins present to enter the dialysate; and thereafter removing from the peritoneal cavity a dialysate aliquot having an increased toxin content.
Claim 6
Dependent Claim
43 words
A substantially glucose-free dialysate composition suitable for peritoneal dialysis and comprising an aqueous dialysis solution containing hydroxypropyl-beta-cyclodextrin having a degree of substitution in the range of about 5 to about 7 and present in a concentration of about 5 to about 35 g/dl.
Claim 7
Dependent Claim
43 words
A substantially glucose-free dialysate composition suitable for peritoneal dialysis and comprising an aqueous dialysis solution containing hydroxypropyl-beta-cyclodextrin having a degree of substitution in the range of about 5 to about 7 and present in a concentration of about 5 to about 35 g/dl.
Claim 8
Dependent Claim
34 words
The aqueous dialysis solution in accordance with claim 4 wherein hydroxypropyl-beta-cyclodextrin having a degree of substitution of about 5 to about 7 is present in a concentration of about 7.5 to about 25 g/dl.
Claim 9
Independent Claim
93 words
A method for peritoneal dialysis which comprises the steps of: providing an aqueous dialysate containing: hydroxypropyl-beta-cyclodextrin having a degree of substitution of about 5 to about 7 in a concentration of about 5 to about 35 g/dl; introducting an aliquot of said dialysate into the peritoneal cavity of the patient in need of dialysis; maintaining the introduced dialysate in the peritoneal cavity for a time period sufficient for toxins and additional water to enter the dialysate; and thereafter removing from the peritoneal cavity a dialysate aliquot having an increased toxin and water content.
Claim 10
Independent Claim
93 words
A method for peritoneal dialysis which comprises the steps of: providing an aqueous dialysate containing: hydroxypropyl-beta-cyclodextrin having a degree of substitution of about 5 to about 7 in a concentration of about 5 to about 35 g/dl; introducting an aliquot of said dialysate into the peritoneal cavity of the patient in need of dialysis; maintaining the introduced dialysate in the peritoneal cavity for a time period sufficient for toxins and additional water to enter the dialysate; and thereafter removing from the peritoneal cavity a dialysate aliquot having an increased toxin and water content.
Claim 11
Dependent Claim
28 words
The method for peritoneal dialysis in accordance with claim 6 wherein hydroxypropyl-beta-cyclodextrin is present in an aqueous dialysate in a concentration of about 7.5 to about 25 g/dl.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1992-12-25 | 1993-06-26 | 1993-12-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-12-25 | 1997-06-26 | 1997-12-26 | $3760.00 | Window Closed / Lapsed |
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