US4879283A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Solution for the preservation of organs
Assignee: Wisconsin Alumni Research Foundation
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Filing: 1987-12-29
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Granted: 1989-11-07
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Expires: 2007-12-29
Abstract
Abstract In accordance with the present invention a method of preserving organs using a perfusate or storage solution containing a specific synthetic hydroxyethyl starch in place of human serum albumin is disclosed. A suitable composition is provided. Disclosed is a cold-storage solution and perfusate that has provided 72 hour preservation for the pancreas, 48 hour storage for the kidney and at least 24 hour preservation for the liver.
Inventors
- 👤 Folkert D. Belzer
- 👤 James H. Southard
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:23
CPC Classifications
A; A01; A01N; A01N1/00; A01N1/10; A01N1/12; A01N1/122; A01N1/126
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
72 words
A solution for the preservation and storage of organs intended for implantation in a patient requiring such implantation, comprising: a pharmacologically acceptable storage solution having a solution osmolality of about 320 mOsm/liter and including a lactobionate salt; and about 5 weight percent hydroxyethyl starch, wherein said starch is substantially free of ethylene glycol, ethylene chlorohydrin, sodium chloride and acetone and has a molecular weight of from about 150,000 to about 350,000 daltons.
Claim 2
Dependent Claim
72 words
A solution for the preservation and storage of organs intended for implantation in a patient requiring such implantation, comprising: a pharmacologically acceptable storage solution having a solution osmolality of about 320 mOsm/liter and including a lactobionate salt; and about 5 weight percent hydroxyethyl starch, wherein said starch is substantially free of ethylene glycol, ethylene chlorohydrin, sodium chloride and acetone and has a molecular weight of from about 150,000 to about 350,000 daltons.
Claim 3
Dependent Claim
73 words
A solution for the preservation and storage of organs intended for implantation in a patent requiring such implantation, comprising: a pharmacologically acceptable storage solution having a solution osmolality of about 320 mOsm/liter; and about 3 to 8 weight percent hydroxyethyl starch, wherein said starch is substantially free of ethylene glycol, ethylene chlorohydrin, sodium chloride and acetone and has a molecular weight of from about 150,000 to about 350,000 daltons, and a lactobionate salt.
Claim 4
Dependent Claim
73 words
A solution for the preservation and storage of organs intended for implantation in a patent requiring such implantation, comprising: a pharmacologically acceptable storage solution having a solution osmolality of about 320 mOsm/liter; and about 3 to 8 weight percent hydroxyethyl starch, wherein said starch is substantially free of ethylene glycol, ethylene chlorohydrin, sodium chloride and acetone and has a molecular weight of from about 150,000 to about 350,000 daltons, and a lactobionate salt.
Claim 5
Dependent Claim
87 words
A solution for the preservation and storage of organs intended for implantation in a patient requiring such implantation, comprising: a pharmacologically acceptable storage solution having a solution osmolality of about 320 mOsm/liter; and about 5 weight percent hydroxyethyl starch, wherein said starch is substantially free of ethylene glycol, ethylene chlorohydrin, sodium chloride and acetone and has a molecular weight of from about 150,000 to about 350,000 daltons and wherein the starch is substantially free of hydroxyethyl starch having a molecular weight of less than about 50,000 daltons.
Claim 6
Dependent Claim
87 words
A solution for the preservation and storage of organs intended for implantation in a patient requiring such implantation, comprising: a pharmacologically acceptable storage solution having a solution osmolality of about 320 mOsm/liter; and about 5 weight percent hydroxyethyl starch, wherein said starch is substantially free of ethylene glycol, ethylene chlorohydrin, sodium chloride and acetone and has a molecular weight of from about 150,000 to about 350,000 daltons and wherein the starch is substantially free of hydroxyethyl starch having a molecular weight of less than about 50,000 daltons.
Claim 7
Dependent Claim
14 words
The solution of claim 3 which includes an electrolyte for maintenance of cell viability.
Claim 8
Dependent Claim
10 words
The solution of claim 3 which includes a lactobionate salt.
Claim 9
Dependent Claim
7 words
The solution of claim 4 including raffinose.
Claim 10
Independent Claim
85 words
A method for the preservation and storage of organs intended for implantation in a patient requiring such implantation, said method comprising: flushing said organ with a solution having an osmolality of about 320 mOsm/liter and including a lactobionate salt and about 5 weight percent hydroxyethyl starch, said starch being substantially free of ethylene glycol, ethylene chlorohydrin, sodium chloride and acetone and having a molecular weight of from about 150,000 to about 350,000 daltons; and storing said organ in said solution until implantation in said patient.
Claim 11
Independent Claim
85 words
A method for the preservation and storage of organs intended for implantation in a patient requiring such implantation, said method comprising: flushing said organ with a solution having an osmolality of about 320 mOsm/liter and including a lactobionate salt and about 5 weight percent hydroxyethyl starch, said starch being substantially free of ethylene glycol, ethylene chlorohydrin, sodium chloride and acetone and having a molecular weight of from about 150,000 to about 350,000 daltons; and storing said organ in said solution until implantation in said patient.
Claim 12
Independent Claim
96 words
A method for the preservation and storage of organs intended for implantation in a patient requiring such implantation, said method comprising: flushing said organ with a solution having an osmolality of about 320 mOsm/liter and about 5 weight percent hydroxyethyl starch, said starch being substantially free of ethylene glycol, ethylene chlorohydrin, sodium chloride and acetone and having a molecular weight of from about 150,000 to about 350,000 daltons and being substantially free of hydroxyethyl starch having a molecular weight less than about 50,000 daltons; and storing said organ in said solution until implantation in said patient.
Claim 13
Independent Claim
96 words
A method for the preservation and storage of organs intended for implantation in a patient requiring such implantation, said method comprising: flushing said organ with a solution having an osmolality of about 320 mOsm/liter and about 5 weight percent hydroxyethyl starch, said starch being substantially free of ethylene glycol, ethylene chlorohydrin, sodium chloride and acetone and having a molecular weight of from about 150,000 to about 350,000 daltons and being substantially free of hydroxyethyl starch having a molecular weight less than about 50,000 daltons; and storing said organ in said solution until implantation in said patient.
Claim 14
Dependent Claim
17 words
The method of claim 8 in which the solution includes an electrolyte for maintenance of cell viability.
Claim 15
Dependent Claim
13 words
The method of claim 8 in which the solution includes a lactobionate salt.
Claim 16
Dependent Claim
11 words
The method of claim 9 in which the solution includes raffinose.
Claim 17
Dependent Claim
11 words
The method of claim 10 in which the solution includes glutathione.
References Cited (Backward Citations)
US3523938A
Cited
DE3030863A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-11-06 | 1993-05-08 | 1993-11-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-11-06 | 1997-05-08 | 1997-11-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-11-06 | 2001-05-08 | 2001-11-07 | $7700.00 | Window Closed / Lapsed |