US4877776A
Expired / Lapsed
US
⏱️ 0.0 years remaining
K-252 compounds
Assignee: KH Neochem Co Ltd
•
Filing: 1988-12-22
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Granted: 1989-10-31
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Expires: 2008-12-22
Abstract
Abstract A K-252 compound represented by the formula: ##STR1## wherein R 1 and R 2 are independently H or OH; X represents COOH, COOR or CH 2 OH; Y represents H, R or COR; and Z represents OH, OR or SR, wherein R represents lower alkyl has C-kinase inhibitory activity and is expected to be useful as an active ingredient of anti-tumor agents, etc.
Inventors
- 👤 Chikara Murakata
- 👤 Akira Sato
- 👤 Masaji Kasai
- 👤 Eiji Kobayashi
- 👤 Makoto Morimoto
- 👤 Shiro Akinaga
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:04
CPC Classifications
C; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/23; A; A61; A61P; A61P35/00
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
46 words
A K- 252 compound represented by the formula: ##STR14## wherein R 1 and R 2 are independently H or OH; X represents COOH, COOR or CH 2 OH; Y represents H, R or COR; and Z represents OH, OR or SR, wherein R represents lower alkyl.
Claim 2
Dependent Claim
46 words
A K- 252 compound represented by the formula: ##STR14## wherein R 1 and R 2 are independently H or OH; X represents COOH, COOR or CH 2 OH; Y represents H, R or COR; and Z represents OH, OR or SR, wherein R represents lower alkyl.
Claim 3
Dependent Claim
23 words
A compound according to claim 1, wherein the lower alkyl is a straight chain or branched alkyl having 1 to 4 carbon atoms.
Claim 4
Dependent Claim
10 words
A compound according to claim 1, wherein Z is OH.
Claim 5
Dependent Claim
10 words
A compound according to claim 1, wherein Z is OR.
Claim 6
Dependent Claim
10 words
A compound according to claim 1, wherein Z is SR.
Claim 7
Dependent Claim
29 words
A compound according to claim 1, wherein R 1 and R 2 are H, X is COOCH 3 , Y is CH 3 and Z is OCH 3 .
Claim 8
Dependent Claim
31 words
A compound according to claim 1, wherein R 1 and R 2 are H, X is COOCH 3 , Y is COCH 3 and Z is OC 2 H 5 .
Claim 9
Dependent Claim
30 words
A compound according to claim 1, wherein R 1 and R 2 are H, X is COOCH 3 , Y is H and Z is OC 2 H 5 .
Claim 10
Dependent Claim
30 words
A compound according to claim 1, wherein R 1 and R 2 are H, X is COOCH 3 , Y is H and Z is SC 2 H 5 .
Claim 11
Dependent Claim
26 words
A compound according to claim 1, wherein R 1 and R 2 are H, X is COOCH 3 , Y is H and Z is OH.
Claim 12
Dependent Claim
26 words
A compound according to claim 1, wherein R 1 and R 2 are H, X is CH 2 OH, Y is H and Z is OH.
Claim 13
Dependent Claim
30 words
A compound according to claim 1, wherein R 1 and R 2 are H, X is CH 2 OH, Y is H and Z is SC 2 H 5 .
Claim 14
Dependent Claim
27 words
A compound according to claim 1, wherein R 1 is OH, R 2 is H, X is COOCH 3 , Y is H and Z is OH.
Claim 15
Dependent Claim
23 words
A pharmaceutical composition comprising a pharmaceutical carrier and, as an active ingredient, an effective amount of a K-252 compound defined in claim 1.
Claim 16
Dependent Claim
35 words
A method for treating diseases due to protein kinase C which comprises administering to a human an effective amount of a pharmaceutical composition comprising a K-252 compound defined in claim 1 and a pharmaceutical carrier.
References Cited (Backward Citations)
US4555402A
Cited
JPS60185719A
Cited
JPS61176531A
Cited
JPS62120388A
Cited
JPS62155284A
Cited
JPS62155285A
Cited
JPS62164626A
Cited
JPS62240689A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-10-30 | 1993-05-01 | 1993-10-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-10-30 | 1997-05-01 | 1997-10-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-10-30 | 2001-05-01 | 2001-10-31 | $7700.00 | Window Closed / Lapsed |