Patent US5643837A successfully refreshed from Google Patents.
US4874746A
Expired / Lapsed
US
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Wound headling composition of TGF-alpha and PDGF
Assignee: Biomimetic Therapeutics LLC
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Filing: 1987-12-22
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Granted: 1989-10-17
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Expires: 2007-12-22
Abstract
Abstract Healing an external wound or regenerating bone of a mammal by administering to the mammal a composition containing purified platelet-derived growth factor and purified transforming growth factor alpha.
Inventors
- 👤 Harry N. Antoniades
- 👤 Samuel E. Lynch
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:55
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/22; A61K38/27; C; C07; C07K; C07K14/00; C07K14/435; C07K14/475; C07K14/49; A61K38/18; A61K38/1841; A61P; A61P17/00; A61P43/00; B; B65; B65D; B65D81/00; B65D81/02; B65D81/05; B65D81/051; B65D81/052
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
32 words
A method for healing an external wound of a mammal comprising applying to said wound a wound-healing amount of a composition comprising purified platelet-derived growth factor and purified transforming growth factor alpha.
Claim 2
Independent Claim
32 words
A method for healing an external wound of a mammal comprising applying to said wound a wound-healing amount of a composition comprising purified platelet-derived growth factor and purified transforming growth factor alpha.
Claim 3
Dependent Claim
30 words
The method of claim 1 wherein the weight to weight ratio of said platelet-derived growth factor to said transforming growth factor alpha in said composition is between 1:4 and 25:1.
Claim 4
Dependent Claim
13 words
The method of claim 2 wherein said ratio is between 1:2 and 10:1.
Claim 5
Dependent Claim
13 words
The method of claim 3 wherein said ratio is about 1:1 to 2:1.
Claim 6
Dependent Claim
25 words
A wound healing composition comprising purified platelet-derived growth factor and purified transforming growth factor alpha, in a weight to weight ratio of 1:4 to 25:1.
Claim 7
Dependent Claim
25 words
A wound healing composition comprising purified platelet-derived growth factor and purified transforming growth factor alpha, in a weight to weight ratio of 1:4 to 25:1.
Claim 8
Dependent Claim
13 words
The composition of claim 5 wherein said ratio is between 1:2 and 10:1.
Claim 9
Dependent Claim
13 words
The composition of claim 6 wherein said ratio is about 1:1 or 2:1.
Claim 10
Independent Claim
32 words
A method for preparing a composition for healing wounds, comprising mixing purified platelet-derived growth factor and purified transforming growth factor alpha in a weight to weight ratio of between 1:4 and 25:1.
Claim 11
Independent Claim
32 words
A method for preparing a composition for healing wounds, comprising mixing purified platelet-derived growth factor and purified transforming growth factor alpha in a weight to weight ratio of between 1:4 and 25:1.
References Cited (Backward Citations)
US4742003A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-10-16 | 1993-04-17 | 1993-10-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-10-16 | 1997-04-17 | 1997-10-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-10-16 | 2001-04-17 | 2001-10-17 | $7700.00 | Window Closed / Lapsed |