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US4851209A Expired / Lapsed US ⏱️ 0.0 years remaining

Diagnostic procedures using radio labeled sucralfate and derivatives or precursors thereof

Assignee: University of California Berkeley
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Filing: 1985-05-16
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Granted: 1989-07-25
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Expires: 2005-05-16
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Abstract

Abstract A novel diagnostic procedure for the in vivo clinical evaluation of gastrointestinal ulcer disease and other diseases associated with loss of mucosal integrity in humans which comprises the oral administration of an effective amount of radio-labeled sucralfate or derivative or precusor thereof or a water soluble, physiologically compatible radiolabeled salt of sucrose suflate to the human host, followed by scintigraphic imaging of the gastrointestinal area of interest with scintigraphic imaging equipment. A novel radiopharmaceutical composition comprising an aqueous solution or suspension containing an amount of a radio-labeled sucralfate or derivative or precursor thereof or a water soluble, physiologically compatible radiolabeled salt of sucrose sulfate for in vivo scintigraphic imaging of the gastrointestinal or other muscosal areas in humans.

Inventors

  • 👤 Vasquez
  • 👤 Robert L. Bridges
  • 👤 Philip Braunstein
  • 👤 Anne-Line Jansholt

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 16:22
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0491; A61K51/12; A61K51/121; A61K51/1217; A61K2123/00

Claims Analysis

Total Claims: 12
Claim 1
Independent Claim 56 words
A method for clinical evaluation of conditions associated with loss of mucosal integrity in humans which comprises: administering orally to a subject in need of such evaluation an effective amount of a polysulfated disaccharide salt labeled by association with a carrier containing a radioisotope detectable by scintigraphic imaging. followed by scintigraphic imaging of the gastrointestinal area.
Claim 2
Independent Claim 56 words
A method for clinical evaluation of conditions associated with loss of mucosal integrity in humans which comprises: administering orally to a subject in need of such evaluation an effective amount of a polysulfated disaccharide salt labeled by association with a carrier containing a radioisotope detectable by scintigraphic imaging. followed by scintigraphic imaging of the gastrointestinal area.
Claim 3
Dependent Claim 12 words
The method of claim 1 wherein the salt is an aluminum salt.
Claim 4
Dependent Claim 11 words
The method of claim 2 wherein the disaccharide salt is sucralfate.
Claim 5
Dependent Claim 10 words
The method of claim 1 wherein the radioisotope is technetium-99.
Claim 6
Dependent Claim 12 words
The method of claim 1 wherein the carrier is human serum albumin.
Claim 7
Dependent Claim 35 words
A composition useful for evaluation by radioimaging of conditions associated with loss of mucosal integrity, which composition comprises an effective amount of polysulfated disaccharide salt associated with a carrier containing a radioisotope detectable by scintigraphy.
Claim 8
Dependent Claim 35 words
A composition useful for evaluation by radioimaging of conditions associated with loss of mucosal integrity, which composition comprises an effective amount of polysulfated disaccharide salt associated with a carrier containing a radioisotope detectable by scintigraphy.
Claim 9
Dependent Claim 12 words
The composition of claim 6 wherein the salt is an aluminum salt.
Claim 10
Dependent Claim 11 words
The composition of claim 7 wherein the disaccharide salt is sucralfate.
Claim 11
Dependent Claim 10 words
The composition of claim 6 wherein the radioisotope is technetium-99.
Claim 12
Dependent Claim 12 words
The composition of claim 6 wherein the carrier is human serum albumin.

References Cited (Backward Citations)

US3432489A Cited
US3852413A Cited
US4243652A Cited
US4385046A Cited
US4581221A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1992-07-24 1993-01-23 1993-07-25 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1996-07-24 1997-01-23 1997-07-25 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2000-07-24 2001-01-23 2001-07-25 $7700.00 Window Closed / Lapsed

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