US4850995A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Centrifugal separation of blood
Assignee: Terumo BCT Inc
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Filing: 1987-08-19
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Granted: 1989-07-25
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Expires: 2007-08-19
Abstract
Abstract Returning red blood cells to a patient after a centrifuge separation procedure by connecting an inflow line of a separation channel to an outflow line to provide a closed loop and recirculating liquid through it to remove blood cells. Also disclosed is pulling more liquid out of a flexible separation channel than permitted into it in order to reduce the volume of liquid to be used in returning cells to the patient.
Inventors
- 👤 Thomas K. Tie
- 👤 Mark A. Holmes
- 👤 Anne W. Rank
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:04
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3693; A61M1/02; A61M1/0209; A61M1/3621; A61M1/3643; A61M1/3644; A61M1/3646; A61M1/3696; A61M1/3601; A61M1/3603; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0429
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
84 words
A method of returning blood cells to a patient/donor after a centrifuge separation procedure comprising providing centrifuge apparatus including a separation channel for separating blood components and an inflow line to and outflow lines from said channel, ending a centrifuge separation procedure by stopping rotation of said separation channel, connecting said inflow line to a said outflow line to provide a closed loop, and recirculating liquid through said channel to free and suspend blood cells in said channel while said channel is not rotating.
Claim 2
Independent Claim
84 words
A method of returning blood cells to a patient/donor after a centrifuge separation procedure comprising providing centrifuge apparatus including a separation channel for separating blood components and an inflow line to and outflow lines from said channel, ending a centrifuge separation procedure by stopping rotation of said separation channel, connecting said inflow line to a said outflow line to provide a closed loop, and recirculating liquid through said channel to free and suspend blood cells in said channel while said channel is not rotating.
Claim 3
Dependent Claim
60 words
The method of claim 1 wherein an outflow line is a red blood cell line for removing red blood cells, and further comprising, prior to said connecting, flushing said red blood cell line to remove red blood cells therein, and thereafter blocking said red blood cell line, and wherein during said recirculating said red blood cell line is maintained blocked.
Claim 4
Dependent Claim
45 words
The method of claim 2, further comprising, prior to said flushing, disconnecting said inflow line from said patient/donor and connecting a supply saline solution to said inflow line, and wherein, after said connecting and prior to said flushing, components separated in said channel are collected.
Claim 5
Independent Claim
111 words
The method of returning blood cells to a patient/donor after a centrifuge separation procedure comprising providing centrifuge apparatus including a flexible separation channel for separating blood components and an inflow line to and outflow lines from said channel, and pulling more liquid out of said channel with an outflow pump than is permitted into said channel in order to substantially collapse said channel to reduce the volume of liquid to be used in returning cells to said patient/donor, and rinsing liquid through said channel while maintaining said channel collapsed to flush blood cells from said channel while using a decreased volume of liquid owing to the decreased volume of said channel.
Claim 6
Independent Claim
111 words
The method of returning blood cells to a patient/donor after a centrifuge separation procedure comprising providing centrifuge apparatus including a flexible separation channel for separating blood components and an inflow line to and outflow lines from said channel, and pulling more liquid out of said channel with an outflow pump than is permitted into said channel in order to substantially collapse said channel to reduce the volume of liquid to be used in returning cells to said patient/donor, and rinsing liquid through said channel while maintaining said channel collapsed to flush blood cells from said channel while using a decreased volume of liquid owing to the decreased volume of said channel.
Claim 7
Dependent Claim
20 words
The method of claim 4 wherein inflow to said channel is blocked during said pulling to substantially collapse said channel.
Claim 8
Dependent Claim
60 words
The method of claim 5 wherein an outflow line is a red blood cell line for removing red blood cells, and further comprising, prior to said pulling, flushing said red blood cell line to remove red blood cells therein, and thereafter blocking said red blood cell line, and wherein during said pulling said red blood cell line is maintained blocked.
Claim 9
Dependent Claim
45 words
The method of claim 5, further comprising, prior to said flushing, disconnecting said inflow line from said patient/donor and connecting a supply saline solution to said inflow line, and wherein, after said connecting and prior to said flushing, components separated in said channel are collected.
Claim 10
Dependent Claim
50 words
The method of claim 1 wherein said channel is flexible, and further comprising, after said recirculating, pulling more liquid out of said channel with an outflow pump than is permitted into said channel in order to reduce the volume of liquid to be used in returning cells to said patient/donor.
Claim 11
Dependent Claim
56 words
The method of claim 8 wherein inflow to said channel is blocked during said pulling to substantially collapse said channel, and further comprising thereafter rinsing liquid through said channel while maintaining said channel collapsed to flush blood cells from said channel while using a decreased volume of liquid owing to the decreased volume of said channel.
Claim 12
Dependent Claim
62 words
The method of claim 1 wherein said apparatus includes an inflow line drip chamber and a return line drip chamber that both have waste lines joined at a waste junction, and wherein said connecting includes operating said valve to cause liquid to be able to flow from said return line drip chamber to said inflow line drip chamber via said waste lines.
Claim 13
Dependent Claim
90 words
The method of claim 1 wherein said outflow lines include a plasma outlet line and a platelet collect outlet line, said plasma outlet line and said platelet collect outlet line each branching into two lines, one each connected to a collection bag and one each joined at a return junction connected to a return line to said patient/donor, and wherein said apparatus includes valves controlling flow through said two lines, and wherein said connecting includes operating said valves to cause liquid to be able to flow through said return junction.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-07-24 | 1993-01-23 | 1993-07-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-07-24 | 1997-01-23 | 1997-07-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-07-24 | 2001-01-23 | 2001-07-25 | $7700.00 | Window Closed / Lapsed |